The effect of aliphatic, naphthenic, and aromatic hydrocarbons on production of reactive oxygen species and reactive nitrogen species in rat brain synaptosome fraction: the involvement of calcium, nitric oxide synthase, mitochondria, and phospholipase A11Abbreviations: BIM, bisindolylmaleimide; [Ca2+]i, concentration of intracellular calcium; ChAT, cholin acetyltransferase; CSA, cyclosporin A; DCF, 2′,7′-dichlorofluorescein; H2DCF-DA, 2′,7′-dichlorodihydrofluorescin diacetate; DEDA, dimethyleicosadienoic acid; ERK, extracellular signal-regulated kinases; Fura-2 AM, 5-oxazolecarboxylic acid, 2-(6-(bis(2-((acetyloxy)methoxy)-2-oxoethyl)amino)-5-(2-(bis(2-((acetyloxy)methoxy)-2oxoethyl)amino)-5-methylphenoxy)ethoxy)-2-benzofuranyl)-, (acetyloxy) methyl ester; GABA-T, gamma-aminobutyric acid transaminase; HBSS, Hanks’ balanced salt solution; La3+, lanthanum; MAPK, mitogen-activated protein kinase; MeHg, methyl mercury; MEK, extracellular signal-regulated protein kinase; MeOH, methanol; MTP, mitochondrial permeability transition pore; L-NAME, Nω-nitro-l-arginine methyl ester; NO·, nitrogen oxide; NOS, NO· synthase; O2·−, superoxide; PLA2, phospholipase A2; PKC, protein kinase C; RNS, reactive nitrogen species; ROS, reactive oxygen species; SOD, superoxide dismutase; TMB, 1,2,4-trimethylbenzene; TMCH, 1,2,4-trimethylcyclohexane; and U73122, 1-(6-[17beta-3-methoxyestra- 1,3,5(10)-trien- 17-yl]-aminohexyl)- 1H-pyrrole-2,5-dione