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Wood, Matt J.; Canonne, Coline; Besnard, Aurélien; Lachish, Shelly; Fairhurst, Stace M.; Liedvogel, Miriam; Boyle, Dave; Patrick, Samantha C.; Josey, Simon; Kirk, Holly; Dean, Ben; Guilford, Tim; McCleery, Robin M.; Perrins, Chris M.; Horswill, Cat

Demographic profiles and environmental drivers of variation relate to individual breeding state in a long-lived trans-oceanic migratory seabird, the Manx shearwater

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Public Library of Science (PLoS), 2021

Published in: PLOS ONE
Porta, Diana Graus; Weiss, Andreas; Fairhurst, Robin A.; Wartmann, Markus; Stamm, Christelle; Reimann, Flavia; Buhles, Alexandra; Kinyamu-Akunda, Jaqueline; Sterker, Dario; Murakami, Masato; Wang, Youzhen; Engelman, Jeffrey; Hofmann, Francesco; Sellers, William R.

Abstract 2098: NVP-FGF401, a first-in-class highly selective and potent FGFR4 inhibitor for the treatment of HCC

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American Association for Cancer Research (AACR), 2017

Published in: Cancer Research
Weiss, Andreas; Porta, Diana Graus; Reimann, Flavia; Buhles, Alexandra; Stamm, Christelle; Fairhurst, Robin A.; Kinyamu-Akunda, Jacqueline; Sterker, Dario; Murakami, Masato; Wartmann, Markus; Wang, Youzhen; Engelman, Jeffrey A.; Hofmann, Francesco; Sellers, Wiliam R.

Abstract 2103: NVP-FGF401: Cellular and in vivo profile of a novel highly potent and selective FGFR4 inhibitor for the treatment of FGF19/FGFR4/KLB+ tumors

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American Association for Cancer Research (AACR), 2017

Published in: Cancer Research
Fairhurst, Robin A.; Knoepfel, Thomas; Leblanc, Catherine; Buschmann, Nicole; Gaul, Christoph; Blank, Jutta; Galuba, Inga; Trappe, Jörg; Zou, Chao; Voshol, Johannes; Genick, Christine; Brunet-Lefeuvre, Peggy; Bitsch, Francis; Graus-Porta, Diana; Furet, Pascal

Approaches to selective fibroblast growth factor receptor 4 inhibition through targeting the ATP-pocket middle-hinge region

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Royal Society of Chemistry (RSC), 2017

Published in: MedChemComm
Dickson, Callum J.; Hornak, Viktor; Velez-Vega, Camilo; McKay, Daniel J. J.; Reilly, John; Sandham, David A.; Shaw, Duncan; Fairhurst, Robin A.; Charlton, Steven J.; Sykes, David A.; Pearlstein, Robert A.; Duca, Jose S.

Uncoupling the Structure–Activity Relationships of β2 Adrenergic Receptor Ligands from Membrane Binding

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American Chemical Society (ACS), 2016

Published in: Journal of Medicinal Chemistry
Cockayne, Sarah; Adamson, Joy; Corbacho Martin, Belen; Fairhurst, Caroline; Hewitt, Catherine; Hicks, Kate; Hull, Robin; Keenan, Anne Maree; Lamb, Sarah E; Loughrey, Lorraine; McIntosh, Caroline; Menz, Hylton B; Redmond, Anthony C; Rodgers, Sara; Vernon, Wesley; Watson, Judith; Torgerson, David

The REFORM study protocol: a cohort randomised controlled trial of a multifaceted podiatry intervention for the prevention of falls in older people

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BMJ, 2014

Published in: BMJ Open
Caravatti, Giorgio; Guagnano, Vito; Fairhurst, Robin; Imbach, Patricia; Bruce, Ian; Knapp, Mark; Furet, Pascal; Fritsch, Christine; Pover, Alain De; Blasco, Francesca; Blanz, Joachim; Seiler, Frank H.; Fabbro, Doriano; Lang, Marc

Abstract 1922: 2-Aminothiazoles as potent and selective PI3Kalpha inhibitors: Discovery of NVP-BYL719 and structural basis for the isoform selectivity

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American Association for Cancer Research (AACR), 2012

Published in: Cancer Research
Battram, Cliff; Charlton, Steven J.; Cuenoud, Bernard; Dowling, Mark R.; Fairhurst, Robin A.; Farr, David; Fozard, John R.; Leighton-Davies, Juliet R.; Lewis, Christine A.; McEvoy, Lorraine; Turner, Robert J.; Trifilieff, Alexandre

In Vitro and in Vivo Pharmacological Characterization of 5-[(R)-2-(5,6-Diethyl-indan-2-ylamino)-1-hydroxy-ethyl]-8-hydroxy-1H-quinolin-2-one (Indacaterol), a Novel Inhaled β2Adrenoceptor Agonist with a 24-h Duration of Action

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American Society for Pharmacology & Experimental Therapeutics (ASPET), 2006

Published in: Journal of Pharmacology and Experimental Therapeutics
Pang, Yuanjie; Kartsonaki, Christiana; Lv, Jun; Millwood, Iona Y; Fairhurst-Hunter, Zammy; Turnbull, Iain; Bragg, Fiona; Hill, Michael R; Yu, Canqing; Guo, Yu; Chen, Yiping; Yang, Ling; Clarke, Robert; Walters, Robin G; Wu, Ming; Chen, Junshi; Li, Liming; Chen, Zhengming; Holmes, Michael V

Adiposity, metabolomic biomarkers, and risk of nonalcoholic fatty liver disease: a case-cohort study

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Elsevier BV, 2022

Published in: The American Journal of Clinical Nutrition
Fairhurst, Robin A.; Furet, Pascal; Imbach-Weese, Patricia; Stauffer, Frédéric; Rueeger, Heinrich; McCarthy, Clive; Ripoche, Sebastien; Oswald, Susanne; Arnaud, Bertrand; Jary, Aline; Maira, Michel; Schnell, Christian; Guthy, Daniel A.; Wartmann, Markus; Kiffe, Michael; Desrayaud, Sandrine; Blasco, Francesca; Widmer, Toni; Seiler, Frank; Gutmann, Sascha; Knapp, Mark; Caravatti, Giorgio

Identification of NVP-CLR457 as an Orally Bioavailable Non-CNS-Penetrant pan-Class IA Phosphoinositol-3-Kinase Inhibitor

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American Chemical Society (ACS), 2022

Published in: Journal of Medicinal Chemistry
Weiss, Andreas; Adler, Flavia; Buhles, Alexandra; Stamm, Christelle; Fairhurst, Robin A.; Kiffe, Michael; Sterker, Dario; Centeleghe, Mario; Wartmann, Markus; Kinyamu-Akunda, Jacqueline; Schadt, Heiko S.; Couttet, Philippe; Wolf, Armin; Wang, Youzhen; Barzaghi-Rinaudo, Patrizia; Murakami, Masato; Kauffmann, Audrey; Knoepfel, Thomas; Buschmann, Nicole; Leblanc, Catherine; Mah, Robert; Furet, Pascal; Blank, Jutta; Hofmann, Francesco; [...]

FGF401, A First-In-Class Highly Selective and Potent FGFR4 Inhibitor for the Treatment of FGF19-Driven Hepatocellular Cancer

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American Association for Cancer Research (AACR), 2019

Published in: Molecular Cancer Therapeutics
Koziczak-Holbro, Magdalena; Rigel, Dean F.; Dumotier, Bérengère; Sykes, David A.; Tsao, Jeffrey; Nguyen, Ngoc-Hong; Bösch, Julian; Jourdain, Marie; Flotte, Ludivine; Adachi, Yuichiro; Kiffe, Michael; Azria, Moïse; Fairhurst, Robin A.; Charlton, Steven J.; Richardson, Brian P.; Lach-Trifilieff, Estelle; Glass, David J.; Ullrich, Thomas; Hatakeyama, Shinji

Pharmacological Characterization of a Novel 5-Hydroxybenzothiazolone-Derived β2-Adrenoceptor Agonist with Functional Selectivity for Anabolic Effects on Skeletal Muscle Resulting in a Wider Cardiovascular Safety Window in Preclinical Studies

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American Society for Pharmacology & Experimental Therapeutics (ASPET), 2019

Published in: Journal of Pharmacology and Experimental Therapeutics
Schadt, Heiko S; Wolf, Armin; Mahl, Joerg Andreas; Wuersch, Kuno; Couttet, Philippe; Schwald, Marianne; Fischer, Audrey; Lienard, Mathilde; Emotte, Corinne; Teng, Chi-Hse; Skuba, Elizabeth; Richardson, Terrilyn A; Manenti, Luigi; Weiss, Andreas; Graus Porta, Diana; Fairhurst, Robin A; Kullak-Ublick, Gerd A; Chibout, Salah-Dine; Pognan, Francois; Kluwe, William; Kinyamu-Akunda, Jacqueline

Bile Acid Sequestration by Cholestyramine Mitigates FGFR4 Inhibition-Induced ALT Elevation

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Oxford University Press (OUP), 2018

Published in: Toxicological Sciences
Cockayne, Sarah; Rodgers, Sara; Green, Lorraine; Fairhurst, Caroline; Adamson, Joy; Scantlebury, Arabella; Corbacho, Belen; Hewitt, Catherine E; Hicks, Kate; Hull, Robin; Keenan, Anne-Maree; Lamb, Sarah E; McIntosh, Caroline; Menz, Hylton B; Redmond, Anthony; Richardson, Zoe; Vernon, Wesley; Watson, Judith; Torgerson, David J

Clinical effectiveness and cost-effectiveness of a multifaceted podiatry intervention for falls prevention in older people: a multicentre cohort randomised controlled trial (the REducing Falls with ORthoses and a Multifaceted podiatry intervention trial)

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National Institute for Health and Care Research, 2017

Published in: Health Technology Assessment
Cockayne, Sarah; Fairhurst, Caroline; Adamson, Joy; Hewitt, Catherine; Hull, Robin; Hicks, Kate; Keenan, Anne-Maree; Lamb, Sarah E.; Green, Lorraine; McIntosh, Caroline; Menz, Hylton B.; Redmond, Anthony C.; Rodgers, Sara; Torgerson, David J.; Vernon, Wesley; Watson, Judith; Knapp, Peter; Rick, Jo; Bower, Peter; Eldridge, Sandra; Madurasinghe, Vichithranie W.; Graffy, Jonathan

An optimised patient information sheet did not significantly increase recruitment or retention in a falls prevention study: an embedded randomised recruitment trial

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Springer Science and Business Media LLC, 2017

Published in: Trials
Wolleb-Gygi, Annemarie; Darbre, Tamis; Siljegovic, Vuk; Keese, Reinhart; Magnus, Philip; Parry, David; Iliadis, Theodore; Eisenbeis, Shane A.; Fairhurst, Robin A.; Hoskins, Bernard F.; Robson, Richard; Scarlett, Nicola V. Y.; Chen, Jian; Huang, Zu-En; Cai, Rui-Fang; Shao, Qian-Fen; Chen, Shi-Ming; Ye, Hong-Juan

Corrigenda

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Royal Society of Chemistry (RSC), 1995

Published in: Journal of the Chemical Society, Chemical Communications
Fairhurst, Robin A.; Knoepfel, Thomas; Buschmann, Nicole; Leblanc, Catherine; Mah, Robert; Todorov, Milen; Nimsgern, Pierre; Ripoche, Sebastien; Niklaus, Michel; Warin, Nicolas; Luu, Van Huy; Madoerin, Mario; Wirth, Jasmin; Graus-Porta, Diana; Weiss, Andreas; Kiffe, Michael; Wartmann, Markus; Kinyamu-Akunda, Jacqueline; Sterker, Dario; Stamm, Christelle; Adler, Flavia; Buhles, Alexandra; Schadt, Heiko; Couttet, Philippe; [...]

Discovery of Roblitinib (FGF401) as a Reversible-Covalent Inhibitor of the Kinase Activity of Fibroblast Growth Factor Receptor 4

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American Chemical Society (ACS), 2020

Published in: Journal of Medicinal Chemistry
Baur, François; Beattie, David; Beer, David; Bentley, David; Bradley, Michelle; Bruce, Ian; Charlton, Steven J.; Cuenoud, Bernard; Ernst, Roland; Fairhurst, Robin A.; Faller, Bernard; Farr, David; Keller, Thomas; Fozard, John R.; Fullerton, Joe; Garman, Sheila; Hatto, Julia; Hayden, Claire; He, Handan; Howes, Colin; Janus, Diana; Jiang, Zhengjin; Lewis, Christine; Loeuillet-Ritzler, Frederique; [...]

The Identification of Indacaterol as an Ultralong-Acting Inhaled β2-Adrenoceptor Agonist

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American Chemical Society (ACS), 2010

Published in: Journal of Medicinal Chemistry
Tong, Jasper W. K.; Kong, Veni P.; Sze, Lily; Gale, Susie; Veto, John; McArdle, Carla; Tunprasert, Thanaporn; Bradley, Victoria; Strike, Siobhan; Tunprasert, Thanaporn; Bradley, Victoria; Strike, Siobhan; Ashford, Robert; Naemi, Roozbeth; Chocklingam, Nachiappan; de Blasc, Xavi; Farndon, Lisa; Robinson, Vicki; Nicholls, Emily; Birch, Tabitha; Birch, Ivan; Otter, Simon; Kumar, Sunil; Gow, Peter; [...]

The College of Podiatry Annual Conference 2015: meeting abstracts : Harrogate, Yorkshire, UK. 19–21 November 2015

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Wiley, 2016

Published in: Journal of Foot and Ankle Research
Ingram, John; Cawley, Scott; Jones, Angela; Coulman, Elinor; Gregory, Clive; Pickles, Tim; Kei, Him Shun Hinson; Fletcher, Paul; Curran, Mike; Prior, Trevor; Formosa, Cynthia; Otter, Simon; Rome, Keith; Gow, Peter; Dalbeth, Nicola; Rohan, Maheswaran; Stewart, Sarah; Aiyer, Ashok; Glasser, Sam; Paton, Joanne; Collings, Richard; Marsden, Jonathan; Torgerson, David; Cockayne, Sarah; [...]

Abstracts from The College of Podiatry Annual Conference 2016 : Glasgow, Scotland. 17‐19 November 2016 : Glasgow, Scotland. 17‐19 November 2016

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Wiley, 2017

Published in: Journal of Foot and Ankle Research

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