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Moors, Tim E.; Mona, Daniel; Luehe, Stefan; Duran-Pacheco, Gonzalo; Spycher, Liz; Mundigl, Olaf; Kaluza, Klaus; Huber, Sylwia; Hug, Melanie N.; Kremer, Thomas; Ritter, Mirko; Dziadek, Sebastian; Dernick, Gregor; van de Berg, Wilma D. J.; Britschgi, Markus

Multi-platform quantitation of alpha-synuclein human brain proteoforms suggests disease-specific biochemical profiles of synucleinopathies

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Springer Science and Business Media LLC, 2022

Published in: Acta Neuropathologica Communications
Reich, Marvin; Paris, Iñaki; Ebeling, Martin; Dahm, Nadine; Schweitzer, Christophe; Reinhardt, Dieter; Schmucki, Roland; Prasad, Megana; Köchl, Fabian; Leist, Marcel; Cowley, Sally A.; Zhang, Jitao David; Patsch, Christoph; Gutbier, Simon; Britschgi, Markus

Alzheimer’s Risk Gene TREM2 Determines Functional Properties of New Type of Human iPSC-Derived Microglia

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Frontiers Media SA, 2021

Published in: Frontiers in Immunology
Gutbier, Simon; Wanke, Florian; Dahm, Nadine; Rümmelin, Anna; Zimmermann, Silke; Christensen, Klaus; Köchl, Fabian; Rautanen, Anna; Hatje, Klas; Geering, Barbara; Zhang, Jitao David; Britschgi, Markus; Cowley, Sally A.; Patsch, Christoph

Large-Scale Production of Human iPSC-Derived Macrophages for Drug Screening

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MDPI AG, 2020

Published in: International Journal of Molecular Sciences
Guerrero-Ferreira, Ricardo; Taylor, Nicholas MI; Arteni, Ana-Andreea; Kumari, Pratibha; Mona, Daniel; Ringler, Philippe; Britschgi, Markus; Lauer, Matthias E; Makky, Ali; Verasdonck, Joeri; Riek, Roland; Melki, Ronald; Meier, Beat H; Böckmann, Anja; Bousset, Luc; Stahlberg, Henning

Two new polymorphic structures of human full-length alpha-synuclein fibrils solved by cryo-electron microscopy

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eLife Sciences Publications, Ltd, 2019

Published in: eLife
Luo, Jian; Elwood, Fiona; Britschgi, Markus; Villeda, Saul; Zhang, Hui; Ding, Zhaoqing; Zhu, Liyin; Alabsi, Haitham; Getachew, Ruth; Narasimhan, Ramya; Wabl, Rafael; Fainberg, Nina; James, Michelle L.; Wong, Gordon; Relton, Jane; Gambhir, Sanjiv S.; Pollard, Jeffrey W.; Wyss-Coray, Tony

Colony-stimulating factor 1 receptor (CSF1R) signaling in injured neurons facilitates protection and survival

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Rockefeller University Press, 2013

Published in: Journal of Experimental Medicine
Hosono-Fukao, Tomomi; Ohtake-Niimi, Shiori; Hoshino, Hitomi; Britschgi, Markus; Akatsu, Hiroyasu; Hossain, Md. Motarab; Nishitsuji, Kazuchika; van Kuppevelt, Toin H.; Kimata, Koji; Michikawa, Makoto; Wyss-Coray, Tony; Uchimura, Kenji

Heparan Sulfate Subdomains that are Degraded by Sulf Accumulate in Cerebral Amyloid ß Plaques of Alzheimer's Disease

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Elsevier BV, 2012

Published in: The American Journal of Pathology
Stefan Grathwohl; Emmanuel Quansah; Nazia Maroof; Jennifer A. Steiner; Liz Spycher; Fethalla Benmansour; Gonzalo Duran-Pacheco; Juliane Siebourg-Polster; Krisztina Oroszlan-Szovik; Helga Remy; Markus Haenggi; Marc Stawiski; Matthias Selhausen; Pierre Mailver; Andreas Wolfert; Thomas Emrich; Zachary Madaj; Arel Su; Martha L. Escobar Galvis; Christoph Mueller; Annika Herrmann; Patrik Brundin; Markus Britschgi

Specific immune modulation of experimental colitis drives enteric alpha-synuclein accumulation and triggers age-related Parkinson-like brain pathology

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2021

Published in: Free Neuropathology
Joerger, Markus; Metaxas, Yannis; Zaman, Khalil; Michielin, Olivier; Mach, Nicolas; Bettini, Adrienne; Schmitt, Andreas M.; Cantoni, Nathan; Caspar, Clemens B.; Stettler, Sonja; Malval, Roma; Pless, Miklos; Britschgi, Christian; Renner, Christoph; Koeberle, Dieter; Schulz, Jessica D.; Kopp, Christoph; Hayoz, Stefanie; Stathis, Anastasios; von Moos, Roger

Outcome and Prognostic Factors of COVID-19 Infection in Swiss Cancer Patients: Final Results of SAKK 80/20 (CaSA)

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MDPI AG, 2022

Published in: Cancers
Gordevicius, Juozas; Li, Peipei; Marshall, Lee L.; Killinger, Bryan A.; Lang, Sean; Ensink, Elizabeth; Kuhn, Nathan C.; Cui, Wei; Maroof, Nazia; Lauria, Roberta; Rueb, Christina; Siebourg-Polster, Juliane; Maliver, Pierre; Lamp, Jared; Vega, Irving; Manfredsson, Fredric P.; Britschgi, Markus; Labrie, Viviane

Epigenetic inactivation of the autophagy–lysosomal system in appendix in Parkinson’s disease

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Springer Science and Business Media LLC, 2021

Published in: Nature Communications
Gries, Manuela; Christmann, Anne; Schulte, Steven; Weyland, Maximilian; Rommel, Stephanie; Martin, Monika; Baller, Marko; Röth, Ralph; Schmitteckert, Stefanie; Unger, Marcus; Liu, Yang; Sommer, Frederik; Mühlhaus, Timo; Schroda, Michael; Timmermans, Jean-Pierre; Pintelon, Isabel; Rappold, Gudrun A.; Britschgi, Markus; Lashuel, Hilal; Menger, Michael D.; Laschke, Matthias W.; Niesler, Beate; Schäfer, Karl-Herbert

Parkinson mice show functional and molecular changes in the gut long before motoric disease onset

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Springer Science and Business Media LLC, 2021

Published in: Molecular Neurodegeneration
Pagano, Gennaro; Boess, Frank G.; Taylor, Kirsten I.; Ricci, Benedicte; Mollenhauer, Brit; Poewe, Werner; Boulay, Anne; Anzures-Cabrera, Judith; Vogt, Annamarie; Marchesi, Maddalena; Post, Anke; Nikolcheva, Tania; Kinney, Gene G.; Zago, Wagner M.; Ness, Daniel K.; Svoboda, Hanno; Britschgi, Markus; Ostrowitzki, Susanne; Simuni, Tanya; Marek, Kenneth; Koller, Martin; Sevigny, Jeff; Doody, Rachelle; Fontoura, Paulo; [...]

A Phase II Study to Evaluate the Safety and Efficacy of Prasinezumab in Early Parkinson's Disease (PASADENA): Rationale, Design, and Baseline Data

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Frontiers Media SA, 2021

Published in: Frontiers in Neurology
Rothschild, Sacha I.; Zippelius, Alfred; Eboulet, Eric I.; Savic Prince, Spasenija; Betticher, Daniel; Bettini, Adrienne; Früh, Martin; Joerger, Markus; Lardinois, Didier; Gelpke, Hans; Mauti, Laetitia A.; Britschgi, Christian; Weder, Walter; Peters, Solange; Mark, Michael; Cathomas, Richard; Ochsenbein, Adrian F.; Janthur, Wolf-Dieter; Waibel, Christine; Mach, Nicolas; Froesch, Patrizia; Buess, Martin; Bohanes, Pierre; Godar, Gilles; [...]

SAKK 16/14: Durvalumab in Addition to Neoadjuvant Chemotherapy in Patients With Stage IIIA(N2) Non–Small-Cell Lung Cancer—A Multicenter Single-Arm Phase II Trial

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American Society of Clinical Oncology (ASCO), 2021

Published in: Journal of Clinical Oncology
Moors, Tim E.; Maat, Christina A.; Niedieker, Daniel; Mona, Daniel; Petersen, Dennis; Timmermans-Huisman, Evelien; Kole, Jeroen; El-Mashtoly, Samir F.; Spycher, Liz; Zago, Wagner; Barbour, Robin; Mundigl, Olaf; Kaluza, Klaus; Huber, Sylwia; Hug, Melanie N.; Kremer, Thomas; Ritter, Mirko; Dziadek, Sebastian; Geurts, Jeroen J. G.; Gerwert, Klaus; Britschgi, Markus; van de Berg, Wilma D. J.

The subcellular arrangement of alpha-synuclein proteoforms in the Parkinson’s disease brain as revealed by multicolor STED microscopy

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Springer Science and Business Media LLC, 2021

Published in: Acta Neuropathologica
Rothschild, Sacha; Zippelius, Alfred; Eboulet, Eric I; Savic, Spasenija; Betticher, Daniel C.; Bettini, Adrienne; Frueh, Martin; Joerger, Markus; Britschgi, Christian; Peters, Solange; Mark, Michael Thomas; Ochsenbein, Adrian; Janthur, Wolf Dieter; Waibel, Christine; Mach, Nicolas; Gonzalez, Michel; Froesch, Patrizia; Godar, Gilles; Rusterholz, Corinne; Pless, Miklos

SAKK 16/14: Anti-PD-L1 antibody durvalumab in addition to neoadjuvant chemotherapy in patients with stage IIIA(N2) non-small cell lung cancer (NSCLC)—A multicenter single-arm phase II trial

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American Society of Clinical Oncology (ASCO), 2020

Published in: Journal of Clinical Oncology
Navarro, Paula P.; Genoud, Christel; Castaño-Díez, Daniel; Graff-Meyer, Alexandra; Lewis, Amanda J.; de Gier, Yvonne; Lauer, Matthias E.; Britschgi, Markus; Bohrmann, Bernd; Frank, Stephan; Hench, Jürgen; Schweighauser, Gabriel; Rozemuller, Annemieke J. M.; van de Berg, Wilma D. J.; Stahlberg, Henning; Shahmoradian, Sarah H.

Cerebral Corpora amylacea are dense membranous labyrinths containing structurally preserved cell organelles

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Springer Science and Business Media LLC, 2018

Published in: Scientific Reports
Czirr, Eva; Castello, Nicholas A.; Mosher, Kira I.; Castellano, Joseph M.; Hinkson, Izumi V.; Lucin, Kurt M.; Baeza-Raja, Bernat; Ryu, Jae Kyu; Li, Lulin; Farina, Sasha N.; Belichenko, Nadia P.; Longo, Frank M.; Akassoglou, Katerina; Britschgi, Markus; Cirrito, John R.; Wyss-Coray, Tony

Microglial complement receptor 3 regulates brain Aβ levels through secreted proteolytic activity

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Rockefeller University Press, 2017

Published in: Journal of Experimental Medicine
Villeda, Saul A.; Luo, Jian; Mosher, Kira I.; Zou, Bende; Britschgi, Markus; Bieri, Gregor; Stan, Trisha M.; Fainberg, Nina; Ding, Zhaoqing; Eggel, Alexander; Lucin, Kurt M.; Czirr, Eva; Park, Jeong-Soo; Couillard-Després, Sebastien; Aigner, Ludwig; Li, Ge; Peskind, Elaine R.; Kaye, Jeffrey A.; Quinn, Joseph F.; Galasko, Douglas R.; Xie, Xinmin S.; Rando, Thomas A.; Wyss-Coray, Tony

The ageing systemic milieu negatively regulates neurogenesis and cognitive function

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Springer Science and Business Media LLC, 2011

Published in: Nature
Britschgi, Markus; Olin, Christopher E.; Johns, Hudson; Takeda-Uchimura, Yoshiko; Rufibach, Kaspar; Tomooka, Beren; Robinson, William H.; Rajadas, Jayakumar; Clark, Christopher M.; Fagan, Anne M.; Galasko, Douglas G.; Holtzman, David M.; Jutel, Marek; Leszek, Jerzy; Li, Gail; Peskind, Elaine R.; Quinn, Joseph F.; Yesavage, Jerome A.; Ghiso, Jorge A.; Wyss-Coray, Tony

P2‐294: Microarray profiling reveals autoantibody reactivities against abnormal amyloid peptide conformations decline with age and in Alzheimer's disease

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Wiley, 2008

Published in: Alzheimer's & Dementia
Ray, Sandip; Britschgi, Markus; Herbert, Charles; Takeda-Uchimura, Yoshiko; Boxer, Adam; Blennow, Kaj; Friedman, Leah F; Galasko, Douglas R; Jutel, Marek; Karydas, Anna; Kaye, Jeffrey A; Leszek, Jerzy; Miller, Bruce L; Minthon, Lennart; Quinn, Joseph F; Rabinovici, Gil D; Robinson, William H; Sabbagh, Marwan N; So, Yuen T; Sparks, D Larry; Tabaton, Massimo; Tinklenberg, Jared; Yesavage, Jerome A; Tibshirani, Robert;

Classification and prediction of clinical Alzheimer's diagnosis based on plasma signaling proteins

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Springer Science and Business Media LLC, 2007

Published in: Nature Medicine
Rothschild, Sacha I.; Zippelius, Alfred; Eboulet, Eric I.; Savic Prince, Spasenija; Betticher, Daniel; Bettini, Adrienne; Früh, Martin; Joerger, Markus; Lardinois, Didier; Gelpke, Hans; Mauti, Laetitia A.; Britschgi, Christian; Weder, Walter; Peters, Solange; Mark, Michael; Cathomas, Richard; Ochsenbein, Adrian F.; Janthur, Wolf-Dieter; Waibel, Christine; Mach, Nicolas; Froesch, Patrizia; Buess, Martin; Bohanes, Pierre; Godar, Gilles; [...]

SAKK 16/14: Durvalumab in Addition to Neoadjuvant Chemotherapy in Patients With Stage IIIA(N2) Non-Small Cell Lung Cancer — A Multicentre Single-Arm Phase II Trial

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Elsevier BV, 2021

Published in: SSRN Electronic Journal

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