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Heidenreich, Julius Frederik [Author] ; Nieswandt, Bernhard [Other]; Gohla, Antje [Other]; Kleinschnitz, Christoph [Other]

Characterization of the widely used Rac1-inhibitors NSC23766 and EHT1864 in mouse platelets

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Würzburg: Universität Würzburg, 2018
Mierke, Claudia Tanja [Author]; Puder, Stefanie [Author]; Aermes, Christian [Author]; Fischer, Tony [Author]; Kunschmann, Tom [Author]

Effect of PAK Inhibition on Cell Mechanics Depends on Rac1

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https://nbn-resolving.org/urn:nbn:de:bsz:15-qucosa2-845027

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Lausanne: Frontiers Research Foundation, [2023]

Published in: Frontiers in cell and developmental biology ; 8, (2020)
Quentin, Jana Kathrin [Author] ; Nalbant, Perihan [Degree supervisor]

Role of the Rac1-P29S driver mutation in tumorigenesis and acquisition of BRAF inhibitor resistance

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Duisburg; Essen: Universität Duisburg-Essen, 2023
Quentin, Jana Kathrin [Author] ; Nalbant, Perihan [Degree supervisor]

Role of the Rac1-P29S driver mutation in tumorigenesis and acquisition of BRAF inhibitor resistance

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https://nbn-resolving.org/urn:nbn:de:hbz:465-20230726-091508-6

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Duisburg; Essen: Universität Duisburg-Essen, 2023
Arnst, Jamie L.; Hein, Ashley L.; Taylor, Margaret A.; Palermo, Nick Y.; Contreras, Jacob I.; Sonawane, Yogesh A.; Wahl, Andrew O.; Ouellette, Michel M.; Natarajan, Amarnath; Yan, Ying

Discovery and characterization of small molecule Rac1 inhibitors

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Impact Journals, LLC, 2017

Published in: Oncotarget
Laurent, Desire; Casagrande, Anne-Sophie; Leblond, Bertrand; Beausoleil, Eric; Taverne, Thierry; Chauvignac, Cedric; Pando, Matt

Abstract C89: Rac1 splicing variant Rac1b: Towards isoform selective inhibitors for the treatment of cancer

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American Association for Cancer Research (AACR), 2009

Published in: Molecular Cancer Therapeutics
Sooman, Linda; Ekman, Simon; Andersson, Claes; Kultima, Hanna Göransson; Isaksson, Anders; Johansson, Fredrik; Bergqvist, Michael; Blomquist, Erik; Lennartsson, Johan; Gullbo, Joachim

Synergistic interactions between camptothecin and EGFR or RAC1 inhibitors and between imatinib and Notch signaling or RAC1 inhibitors in glioblastoma cell lines

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Springer Science and Business Media LLC, 2013

Published in: Cancer Chemotherapy and Pharmacology
González, Jessica Colón; Fuentes, María C. Santa María; Vlaar, Cornelis; Dharmawardhane, Suranganie

Abstract 1881: Screening of Rac1 and Cdc42 inhibitors as anti-metastatic compounds

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American Association for Cancer Research (AACR), 2024

Published in: Cancer Research
Silverman, Robert; Cooper, Alan; Kar, Ronodip; Raman, Mayuri V.; Ravirala, Ramu; Shah, Mubarak Hasan; Mahankali, Sandeep; Goka, Erik T.

Abstract 677: Discovery of a first-in-class allosteric inhibitor of the small GTPase Rac1

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American Association for Cancer Research (AACR), 2024

Published in: Cancer Research
Møller, Lisbeth L. V.; Ali, Mona S.; Davey, Jonathan; Raun, Steffen H.; Andersen, Nicoline R.; Long, Jonathan Z.; Qian, Hongwei; Jeppesen, Jacob F.; Henriquez-Olguin, Carlos; Frank, Emma; Jensen, Thomas E.; Højlund, Kurt; Wojtaszewski, Jørgen F. P.; Nielsen, Joachim; Chiu, Tim T.; Jedrychowski, Mark P.; Gregorevic, Paul; Klip, Amira; Richter, Erik A.; Sylow, Lykke

The Rho guanine dissociation inhibitor α inhibits skeletal muscle Rac1 activity and insulin action

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Proceedings of the National Academy of Sciences, 2023

Published in: Proceedings of the National Academy of Sciences
Parapini, Silvia; Paone, Silvio; Erba, Emanuela; Cavicchini, Loredana; Pourshaban, Manoochehr; Celani, Francesco; Contini, Alessandro; D’Alessandro, Sarah; Olivieri, Anna

In Vitro Antimalarial Activity of Inhibitors of the Human GTPase Rac1

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American Society for Microbiology, 2022

Published in: Antimicrobial Agents and Chemotherapy
Madhukar, Geet; Subbarao, Naidu

Identification of potent and novel inhibitors against RAC1: a Rho family GTPase

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Springer Science and Business Media LLC, 2022

Published in: In Silico Pharmacology
Cardama, Georgina A.; Maggio, Julian; Valdez Capuccino, Lucas; Gonzalez, Nazareno; Matiller, Valentina; Ortega, Hugo H.; Perez, German R.; Demarco, Ignacio A.; Spitzer, Eduardo; Gomez, Daniel E.; Lorenzano Menna, Pablo; Alonso, Daniel F.

Preclinical Efficacy and Toxicology Evaluation of RAC1 Inhibitor 1A-116 in Human Glioblastoma Models

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MDPI AG, 2022

Published in: Cancers
Medina, Julia I.; Bayro, Marvin; Hernandez, Eliud; Vlaar, Cornelis; Gonzalez, Ricardo; Dharmawardhane, Suranganie

Abstract 4018: Interaction site elucidation of the Rac1/Cdc42 inhibitor, MBQ-167

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American Association for Cancer Research (AACR), 2020

Published in: Cancer Research
Garitano-Trojaola, Andoni; Sancho, Ana; Goetz, Ralph; Walz, Susanne; Jetani, Hardikkumar; Teufel, Eva; Rodhes, Nadine; DaVia, Matteo; Haertle, Larissa; Nerreter, Silvia; Vogt, Cornelia; Duell, Johannes; Tibes, Raoul; Kraus, Sabrina; Rosenwald, Andreas; Rasche, Leo; Hudecek, Michael; Sauer, Markus; Einsele, Hermann; Groll, Jürgen; Kortüm, Martin

RAC1 Inhibitor EHT1864 and Venetoclax Overcome Midostaurin Resistance in Acute Myeloid Leukemia

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American Society of Hematology, 2019

Published in: Blood
Araiza-Olivera, D; Feng, Y; Semenova, G; Prudnikova, T Y; Rhodes, J; Chernoff, J

Suppression of RAC1-driven malignant melanoma by group A PAK inhibitors

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Springer Science and Business Media LLC, 2018

Published in: Oncogene
Sun, Ying; Guo, Chen; Ma, Ping; Lai, Yumei; Yang, Fan; Cai, Jun; Cheng, Zhehao; Zhang, Kuo; Liu, Zhongzhen; Tian, Yeteng; Sheng, Yue; Tian, Ruijun; Deng, Yi; Xiao, Guozhi; Wu, Chuanyue

Kindlin-2 Association with Rho GDP-Dissociation Inhibitor α Suppresses Rac1 Activation and Podocyte Injury

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Ovid Technologies (Wolters Kluwer Health), 2017

Published in: Journal of the American Society of Nephrology
Cabrera, Maia; Echeverria, Emiliana; Lenicov, Federico Remes; Cardama, Georgina; Gonzalez, Nazareno; Davio, Carlos; Fernández, Natalia; Menna, Pablo Lorenzano

Pharmacological Rac1 inhibitors with selective apoptotic activity in human acute leukemic cell lines

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Impact Journals, LLC, 2017

Published in: Oncotarget
Wang, Yuan; Yan, Feng; Ye, Qing; Wu, Xiao; Jiang, Fan

PTP1B inhibitor promotes endothelial cell motility by activating the DOCK180/Rac1 pathway

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Springer Science and Business Media LLC, 2016

Published in: Scientific Reports
Seidelin, Jakob Benedict; Larsen, Sylvester; Linnemann, Dorte; Vainer, Ben; Coskun, Mehmet; Troelsen, Jesper Thorvald; Nielsen, Ole Haagen

Cellular inhibitor of apoptosis protein 2 controls human colonic epithelial restitution, migration, and Rac1 activation

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American Physiological Society, 2015

Published in: American Journal of Physiology-Gastrointestinal and Liver Physiology

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