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Pugsley, Michael K.; Saint, David A.; Hayes, Eric S.; Kramer, David; Walker, M. J. A.Sodium Channel-Blocking Properties of Spiradoline, a κ Receptor Agonist, are Responsible for Its Antiarrhythmic Action in the RatView onlineSchließen
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Published in: Journal of Cardiovascular Pharmacology
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Boulay, Emmanuel; Troncy, Eric; Jacquemet, Vincent; Huang, Hai; Pugsley, Michael K; Downey, Anne-Marie; Venegas Baca, Rafael; Authier, SimonIn Silico Human Cardiomyocyte Action Potential Modeling: Exploring Ion Channel Input CombinationsView onlineSchließen
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Published in: International Journal of Toxicology
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Orciani, Chiara; Ballesteros, Cristina; Troncy, Eric; Berthome, Clemence; Bujold, Kim; Bennamoune, Nehla; Sparapani, Samantha; Pugsley, Michael K.; Paquette, Dominique; Boulay, Emmanuel; Authier, SimonThe Spontaneous Incidence of Neurological Clinical Signs in Preclinical Species Using Cage-side Observations or High-definition Video Monitoring: A Retrospective AnalysisView onlineSchließen
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Published in: International Journal of Toxicology
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Valentin, Jean-Pierre; Hoffmann, Peter; Ortemann-Renon, Catherine; Koerner, John; Pierson, Jennifer; Gintant, Gary; Willard, James; Garnett, Christine; Skinner, Matthew; Vargas, Hugo M; Wisialowski, Todd; Pugsley, Michael KThe Challenges of Predicting Drug-Induced QTc Prolongation in HumansView onlineSchließen
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Published in: Toxicological Sciences
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Authier, Simon; Brock, William J; Halpern, Wendy; Harris, Stephanie N; Jones, David; McGovern, Timothy; McGovern, Pamela D; Pugsley, Michael KCurrent Trends of Practices in Nonclinical Toxicology: An Industry SurveyView onlineSchließen
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Published in: International Journal of Toxicology
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Devsi, Alykhan; Kiyota, Brett; Ouellette, Theophile; Hegle, Andrew P.; Rivera-Acevedo, Ricardo E.; Wong, Jasper; Dong, Ying; Pugsley, Michael K.; Fung, TimothyA pharmacological characterization of Cannabis sativa chemovar extractsView onlineSchließen
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Published in: Journal of Cannabis Research
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Vargas, Hugo M; Bass, Alan S; Koerner, John; Matis‐Mitchell, Sherri; Pugsley, Michael K; Skinner, Matthew; Burnham, Matthew; Bridgland‐Taylor, Matthew; Pettit, Syril; Valentin, Jean‐PierreEvaluation of drug‐induced QT interval prolongation in animal and human studies: a literature review of concordanceView onlineSchließen
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Published in: British Journal of Pharmacology
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Boulay, Emmanuel; Troncy, Eric; Accardi, Michael V.; Pugsley, Michael K.; Downey, Anne-Marie; Miraucourt, Lois; Huang, Hai; Menard, Ariane; Tan, Wendy; Dubuc-Mageau, Michelle; Sanfacon, Audrey; Guerrier, Mireille; Authier, SimonConfounders and Pharmacological Characterization When Using the QT, JTp, and Tpe Intervals in Beagle DogsView onlineSchließen
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Published in: International Journal of Toxicology
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Bain, Allen I.; Barrett, Terrance D.; Beatch, Gregory N.; Fedida, David; Hayes, Eric S.; Plouvier, Bertrand; Pugsley, Michael K.; Walker, Michael J.A.; Walker, Mariah L.; Wall, Richard A.; Yong, Sandro L.; Zolotoy, AlexanderBetter antiarrhythmics? Development of antiarrhythmic drugs selective for ischaemia-dependent arrhythmiasView onlineSchließen
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Published in: Drug Development Research
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Rodriguez, Ignacio; Erdman, Andrew; Padhi, Desmond; Garnett, Christine E.; Zhao, Hong; Targum, Shari L.; Balakrishnan, Suchitra; Strnadova, Colette; Viner, Norman; Geiger, Mary Jane; Newton-Cheh, Christopher; Litwin, Jeffrey; Pugsley, Michael K.; Sager, Philip T.; Krucoff, Mitchell W.; Finkle, John K.Electrocardiographic assessment for therapeutic proteins—scientific discussionView onlineSchließen
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Published in: American Heart Journal
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Cutler, Jevon A.; Pugsley, Haley R.; Bennington, Richard; Fritschle, Wayne; Hartmann, Luise; Zaidi, Nigar; Menssen, Andrew J.; Singleton, Timothy P.; Xu, Dongbin; Loken, Michael R.; Wells, Denise A.; Brodersen, Lisa Eidenschink; Zehentner, Barbara K.Integrated analysis of genotype and phenotype reveals clonal evolution and cytogenetically driven disruption of myeloid cell maturation in myelodysplastic syndromesView onlineSchließen
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Published in: Cytometry Part B: Clinical Cytometry
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Authier, Simon; Abernathy, Matthew M.; Correll, Krystle; Chui, Ray W.; Dalton, Jill; Foley, C. Michael; Friedrichs, Gregory S.; Koerner, John E.; Kallman, Mary-Jeanne; Pannirselvam, Malar; Redfern, William S.; Urmaliya, Vijay; Valentin, Jean-Pierre; Wisialowski, Todd; Zabka, Tanja S.; Pugsley, Michael K.An Industry Survey With Focus on Cardiovascular Safety Pharmacology Study Design and Data InterpretationView onlineSchließen
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Published in: International Journal of Toxicology
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Boulay, Emmanuel; Abernathy, Matthew M.; Chui, Ray; Friedrichs, Gregory S.; Gendron-Parra, Nicolas; Greiter-Wilke, Andrea; Guillon, Jean-Michel; Koerner, John E.; Menard, Ariane; Steidl-Nichols, Jill; Pierson, Jennifer; Pugsley, Michael K.; Rossman, Eric I.; Strauss, David; Troncy, Eric; Valentin, Jean-Pierre; Wisialowski, Todd; Authier, SimonA Proof-of-Concept Evaluation of JTPc and Tp-Tec as Proarrhythmia Biomarkers in Preclinical Species: A Retrospective Analysis by an HESI-Sponsored ConsortiumView onlineSchließen
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Published in: International Journal of Toxicology
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Oster, Matthew E.; Shay, David K.; Su, John R.; Gee, Julianne; Creech, C. Buddy; Broder, Karen R.; Edwards, Kathryn; Soslow, Jonathan H.; Dendy, Jeffrey M.; Schlaudecker, Elizabeth; Lang, Sean M.; Barnett, Elizabeth D.; Ruberg, Frederick L.; Smith, Michael J.; Campbell, M. Jay; Lopes, Renato D.; Sperling, Laurence S.; Baumblatt, Jane A.; Thompson, Deborah L.; Marquez, Paige L.; Strid, Penelope; Woo, Jared; Pugsley, River; Reagan-Steiner, Sarah; [...]Myocarditis Cases Reported After mRNA-Based COVID-19 Vaccination in the US From December 2020 to August 2021View onlineSchließen
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Published in: JAMA
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Pugsley, David; Trombley, Frank R.; Metcalf, D. M.; Queller, Donald E.; Anderson, M. S.; Guilmartin, J. F.; Flint, Valerie I. J.; Meyerson, Mark D.; Trumpener, Ulrich; Burkholder, Mark A.; Jordan, Winthrop D.; Frick, David A.; Dennerline, Jerry; Ditchfield, Simon; Borah, Woodrow; Hampson, Norman; Strachan, Hew; Moran, Daniel; McLaren, Martha; Hoerder, Dirk; Beeler, John; Rich, Norman; MacKenzie, John M.; Charmley, Anglia John; [...]Book ReviewsView onlineSchließen
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Published in: The International History Review
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Edwards, Mark R.; Forbes, Gordon; Walker, Neil; Morton, Dion G.; Mythen, Monty G.; Murray, Dave; Anderson, Iain; Mihaylova, Borislava; Thomson, Ann; Taylor, Matt; Hollyman, Marianne; Phillips, Rachel; Young, Keith; Kahan, Brennan C.; Pearse, Rupert M.; Grocott, Michael P. W.; Skubala, Alexandra; Tapley, Patrick; Kellett, Suzanne; Bolger, Clare; Burnish, Rachel; Collings, Nikki; Cumpstey, Andrew; Wong, Hannah; [...]Fluid Optimisation in Emergency Laparotomy (FLO-ELA) Trial: study protocol for a multi-centre randomised trial of cardiac output-guided fluid therapy compared to usual care in patients undergoing major emergency gastrointestinal surgeryView onlineSchließen
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Published in: Trials
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Haas, Sylvia; Camm, John A.; Harald, Darius; Steffel, Jan; Virdone, Saverio; Pieper, Karen; Brodmann, Marianne; Schellong, Sebastian; Misselwitz, Frank; Kayani, Gloria; Kakkar, Ajay K.; Kakkar, Ajay K.; Bassand, Jean-Pierre; Camm, A. John; Fitzmaurice, David A.; Fox, Keith A. A.; Gersh, Bernard J.; Goldhaber, Samuel Z.; Goto, Shinya; Haas, Sylvia; Hacke, Werner; Mantovani, Lorenzo G.; Misselwitz, Frank; Pieper, Karen S.; [...]GARFIELD-AF: risk profiles, treatment patterns and 2-year outcomes in patients with atrial fibrillation in Germany, Austria and Switzerland (DACH) compared to 32 countries in other regions worldwideView onlineSchließen
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Published in: Clinical Research in Cardiology