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Wanngren, Johanna [Author]

Molecular studies of the γ-secretase complex : focus on genetic and pharmacological modulation

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[Erscheinungsort nicht ermittelbar]: Inst för neurobiologi, vårdvetenskap och samhälle / Dept of Neurobiology, Care Sciences and Society, 2012
Rudan Njavro, Jasenka [Author]; Klotz, Jakob [Author]; Dislich, Bastian [Author]; Wanngren, Johanna [Author]; Shmueli, Merav D. [Author]; Herber, Julia [Author]; Kuhn, Peer-Hendrik [Author]; Kumar, Rohit [Author]; Köglsperger, Thomas [Author]; Conrad, Marcus [Author]; Wurst, Wolfgang [Author]; Feederle, Regina [Author]; Vlachos, Andreas [Author]; Michalakis, Stylianos [Author]; Jedlička, Peter [Author]; Müller, Stephan Andreas [Author]; Lichtenthaler, Stefan [Author]

Mouse brain proteomics establishes MDGA1 and CACHD1 as in vivo substrates of the Alzheimer protease BACE1

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Hoboken, NJ: Wiley, 2020

Published in: The FASEB Journal ; 34, 2 (2020), 2465-2482
Pamrén, Annelie; Wanngren, Johanna; Vasquez, Patricia Lara; Karin Öjemalm; Maioli, Silvia; Nilsson, IngMarie; Karlström, Helena

P2‐089: Functional analysis of a nicastrin‐independent gamma‐secretase complex containing an artificial double mutation in presenilin 1

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Wiley, 2012

Published in: Alzheimer's & Dementia, 8 (2012) 4S_Part_8
Pamrén, Annelie; Wanngren, Johanna; Tjernberg, Lars O.; Winblad, Bengt; Bhat, Ratan; Näslund, Jan; Karlström, Helena

Mutations in Nicastrin Protein Differentially Affect Amyloid β-Peptide Production and Notch Protein Processing

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Elsevier BV, 2011

Published in: Journal of Biological Chemistry, 286 (2011) 36, Seite 31153-31158
Svensson, Annelie; Wanngren, Johanna; Vasquez, Patricia Lara; Geiger, Karin; Nilsson, IngMarie; Karlström, Helena

P2‐314: Molecular studies of nicastrin in the γ‐Secretase complex using an artificial nicastrin independent presenilin 1 double mutant

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Wiley, 2011

Published in: Alzheimer's & Dementia, 7 (2011) 4S_Part_12
Vasquez, Patricia Lara; Wanngren, Johanna; Maioli, Silvia; Tjernberg, Lars; Winblad, Bengt; Lundkvist, Johan; Nilsson, IngMarie; Karlström, Helena

O2‐04‐06: The role of presenilin 1 familial Alzheimer's disease mutations for gamma‐secretase activity and changed structural conformation

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Wiley, 2012

Published in: Alzheimer's & Dementia, 8 (2012) 4S_Part_7
Wanngren, Johanna; Lara, Patricia; Öjemalm, Karin; Maioli, Silvia; Moradi, Nasim; Chen, Lu; Tjernberg, Lars O.; Lundkvist, Johan; Nilsson, IngMarie; Karlström, Helena

Changed membrane integration and catalytic site conformation are two mechanisms behind the increased Aβ42/Aβ40 ratio by presenilin 1 familial Alzheimer‐linked mutations

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Wiley, 2014

Published in: FEBS Open Bio, 4 (2014) 1, Seite 393-406
Wanngren, Johanna; Ottervald, Jan; Parpal, Santiago; Portelius, Erik; Strömberg, Kia; Borgegård, Tomas; Klintenberg, Rebecka; Juréus, Anders; Blomqvist, Jenny; Blennow, Kaj; Zetterberg, Henrik; Lundkvist, Johan; Rosqvist, Susanne; Karlström, Helena

Second Generation γ-Secretase Modulators Exhibit Different Modulation of Notch β and Aβ Production

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Elsevier BV, 2012

Published in: Journal of Biological Chemistry, 287 (2012) 39, Seite 32640-32650
Wanngren, Johanna; Ottervald, Jan; Parpal, Santiago; Olsson, Fredrik; Strömberg, Kia; Blomqvist, Jenny; Wollberg, Patrik; Malinowsky, David; Winblad, Bengt; Lundkvist, Johan; Rosqvist, Susanne; Karlström, Helena

P2‐317: Impact of different γ‐secretase modulators on Notch‐1 Abeta‐like peptide (Nβ) formation

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Wiley, 2011

Published in: Alzheimer's & Dementia, 7 (2011) 4S_Part_12
Wanngren, Johanna; Frånberg, Jenny; Svensson, Annelie I.; Laudon, Hanna; Olsson, Fredrik; Winblad, Bengt; Liu, Frank; Näslund, Jan; Lundkvist, Johan; Karlström, Helena

The Large Hydrophilic Loop of Presenilin 1 Is Important for Regulating γ-Secretase Complex Assembly and Dictating the Amyloid β Peptide (Aβ) Profile without Affecting Notch Processing

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Elsevier BV, 2010

Published in: Journal of Biological Chemistry, 285 (2010) 12, Seite 8527-8536
Weber, Tobias A.; Lundkvist, Johan; Wanngren, Johanna; Kvartsberg, Hlin; Jin, ShaoBo; Larssen, Pia; Wu, Dan; Oliveira, Daniel V.; Minta, Karolina; Brinkmalm, Gunnar; Zetterberg, Henrik; Blennow, Kaj; Nordvall, Gunnar; Winblad, Bengt; Portelius, Erik; Karlström, Helena

γ‐Secretase modulators show selectivity for γ‐secretase–mediated amyloid precursor protein intramembrane processing

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Wiley, 2022

Published in: Journal of Cellular and Molecular Medicine, 26 (2022) 3, Seite 880-892
Rudan Njavro, Jasenka; Klotz, Jakob; Dislich, Bastian; Wanngren, Johanna; Shmueli, Merav D.; Herber, Julia; Kuhn, Peer‐Hendrik; Kumar, Rohit; Koeglsperger, Thomas; Conrad, Marcus; Wurst, Wolfgang; Feederle, Regina; Vlachos, Andreas; Michalakis, Stylianos; Jedlicka, Peter; Müller, Stephan A.; Lichtenthaler, Stefan F.

Mouse brain proteomics establishes MDGA1 and CACHD1 as in vivo substrates of the Alzheimer protease BACE1

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Wiley, 2020

Published in: The FASEB Journal, 34 (2020) 2, Seite 2465-2482
Pigoni, Martina; Wanngren, Johanna; Kuhn, Peer-Hendrik; Munro, Kathryn M.; Gunnersen, Jenny M.; Takeshima, Hiroshi; Feederle, Regina; Voytyuk, Iryna; De Strooper, Bart; Levasseur, Mikail D.; Hrupka, Brian J.; Müller, Stephan A.; Lichtenthaler, Stefan F.

Seizure protein 6 and its homolog seizure 6-like protein are physiological substrates of BACE1 in neurons

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Springer Science and Business Media LLC, 2016

Published in: Molecular Neurodegeneration, 11 (2016) 1
Laurent, Sarah A.; Hoffmann, Franziska S.; Kuhn, Peer-Hendrik; Cheng, Qingyu; Chu, Yuanyuan; Schmidt-Supprian, Marc; Hauck, Stefanie M.; Schuh, Elisabeth; Krumbholz, Markus; Rübsamen, Heike; Wanngren, Johanna; Khademi, Mohsen; Olsson, Tomas; Alexander, Tobias; Hiepe, Falk; Pfister, Hans-Walter; Weber, Frank; Jenne, Dieter; Wekerle, Hartmut; Hohlfeld, Reinhard; Lichtenthaler, Stefan F.; Meinl, Edgar

γ-secretase directly sheds the survival receptor BCMA from plasma cells

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Springer Science and Business Media LLC, 2015

Published in: Nature Communications, 6 (2015) 1
Borgegård, Tomas; Gustavsson, Susanne; Nilsson, Charlotte; Parpal, Santiago; Klintenberg, Rebecka; Berg, Anna-Lena; Rosqvist, Susanne; Serneels, Lutgarde; Svensson, Samuel; Olsson, Fredrik; Jin, Shaobo; Yan, Hongmei; Wanngren, Johanna; Jureus, Anders; Ridderstad-Wollberg, Anna; Wollberg, Patrik; Stockling, Kenneth; Karlström, Helena; Malmberg, Åsa; Lund, Johan; Arvidsson, Per I.; De Strooper, Bart; Lendahl, Urban; Lundkvist, Johan

Alzheimer's Disease: Presenilin 2-Sparing γ-Secretase Inhibition Is a Tolerable Aβ Peptide-Lowering Strategy

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Society for Neuroscience, 2012

Published in: The Journal of Neuroscience, 32 (2012) 48, Seite 17297-17305

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