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Hendrikx, J J M A; Lagas, J S; Wagenaar, E; Rosing, H; Schellens, J H M; Beijnen, J H; Schinkel, A H

Oral co-administration of elacridar and ritonavir enhances plasma levels of oral paclitaxel and docetaxel without affecting relative brain accumulation

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Springer Science and Business Media LLC, 2014

Published in: British Journal of Cancer, 110 (2014) 11, Seite 2669-2676
Bauer, Martin; Zeitlinger, Markus; Dobrozemsky, Georg; Philippe, Cécile; Müller, Markus; Langer, Oliver

[11C]Elacridar as a novel P-glycoprotein PET tracer, assessment of whole-body distribution and radiation dosimetry in humans

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Springer Science and Business Media LLC, 2011

Published in: BMC Pharmacology, 11 (2011) S2
Kuntner, Claudia; Bankstahl, Jens P; Bankstahl, Marion; Stanek, Johann; Wanek, Thomas; Dörner, Bernd; Bauer, Florian; Mairinger, Severin; Erker, Thomas; Müller, Markus; Löscher, Wolfgang; Langer, Oliver

Evaluation of [11C]elacridar and [11C]tariquidar in transporter knockout mice using small-animal PET

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Elsevier BV, 2010

Published in: NeuroImage, 52 (2010), Seite S25
Hubensack, Martina; Müller, Christine; Höcherl, Peter; Fellner, Stephan; Spruss, Thilo; Bernhardt, Günther; Buschauer, Armin

Effect of the ABCB1 modulators elacridar and tariquidar on the distribution of paclitaxel in nude mice

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Springer Science and Business Media LLC, 2008

Published in: Journal of Cancer Research and Clinical Oncology, 134 (2008) 5, Seite 597-607
Bihorel, Sébastien; Camenisch, Gian; Lemaire, Michel; Scherrmann, Jean-Michel

Modulation of the Brain Distribution of Imatinib and its Metabolites in Mice by Valspodar, Zosuquidar and Elacridar

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Springer Science and Business Media LLC, 2007

Published in: Pharmaceutical Research, 24 (2007) 9, Seite 1720-1728
De Lagerie, Sylvie Barraud; Comets, Emmanuelle; Gautrand, Céline; Fernandez, Christine; Auchere, Daniel; Singlas, Eric; Mentre, France; Gimenez, François

Cerebral uptake of mefloquine enantiomers with and without the P‐gp inhibitor elacridar (GF1210918) in mice

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Wiley, 2004

Published in: British Journal of Pharmacology, 141 (2004) 7, Seite 1214-1222
Kuehne, Annett; Floerl, Saskia; Hagos, Yohannes

Investigations with Drugs and Pesticides Revealed New Species- and Substrate-Dependent Inhibition by Elacridar and Imazalil in Human and Mouse Organic Cation Transporter OCT2

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MDPI AG, 2022

Published in: International Journal of Molecular Sciences, 23 (2022) 24, Seite 15795
Wang, Jing; Susam, M. Merve; Gan, Changpei; Sparidans, Rolf W.; Lebre, Maria C.; Beijnen, Jos H.; Schinkel, Alfred H.

P-Glycoprotein (MDR1/ABCB1) Restricts Brain Accumulation of the Novel EGFR Inhibitor EAI045 and Oral Elacridar Coadministration Enhances Its Brain Accumulation and Oral Exposure

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MDPI AG, 2022

Published in: Pharmaceuticals, 15 (2022) 9, Seite 1124
Suzuki, Kei; Taniyama, Kazuhiro; Aoyama, Takao; Watanabe, Yoshiaki

Evaluation of the Role of P-glycoprotein (P-gp)-Mediated Efflux in the Intestinal Absorption of Common Substrates with Elacridar, a P-gp Inhibitor, in Rats

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Springer Science and Business Media LLC, 2020

Published in: European Journal of Drug Metabolism and Pharmacokinetics, 45 (2020) 3, Seite 385-392
Karbownik, Agnieszka; Sobańska, Katarzyna; Płotek, Włodzimierz; Grabowski, Tomasz; Klupczynska, Agnieszka; Plewa, Szymon; Grześkowiak, Edmund; Szałek, Edyta

The influence of the coadministration of the p-glycoprotein modulator elacridar on the pharmacokinetics of lapatinib and its distribution in the brain and cerebrospinal fluid

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Springer Science and Business Media LLC, 2020

Published in: Investigational New Drugs, 38 (2020) 3, Seite 574-583
Chen D; Pan X; Xie F; Lu Y; Zou H; Yin C; Zhang Y; Gao J

Codelivery of doxorubicin and elacridar to target both liver cancer cells and stem cells by polylactide-co-glycolide/d-alpha-tocopherol polyethylene glycol 1000 succinate nanoparticles

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2018

Published in: International Journal of Nanomedicine (2018), Seite 6855-6870
Chen, Dazhong; Pan, Xiaoli; Xie, Fangyuan; Lu, Ying; Zou, Hao; Yin, Chuan; Zhang, Yu; Gao, Jie

Codelivery of doxorubicin and elacridar to target both liver cancer cells and stem cells by polylactide-co-glycolide/d-alpha-tocopherol polyethylene glycol 1000 succinate nanoparticles

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Informa UK Limited, 2018

Published in: International Journal of Nanomedicine, Volume 13 (2018), Seite 6855-6870
Verheijen, Remy B.; Yaqub, Maqsood; Sawicki, Emilia; van Tellingen, Olaf; Lammertsma, Adriaan A.; Nuijen, Bastiaan; Schellens, Jan H.M.; Beijnen, Jos H.; Huitema, Alwin D.R.; Hendrikse, N. Harry; Steeghs, Neeltje

Molecular Imaging of ABCB1 and ABCG2 Inhibition at the Human Blood–Brain Barrier Using Elacridar and 11C-Erlotinib PET

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Society of Nuclear Medicine, 2018

Published in: Journal of Nuclear Medicine, 59 (2018) 6, Seite 973-979
Highly Eribulin-resistant KBV20C Oral Cancer Cells Can Be Sensitized by Co-treatment with the Third-generation P-Glycoprotein Inhibitor, Elacridar, at a Low Dose

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Anticancer Research USA Inc., 2017

Published in: Anticancer Research, 37 (2017) 8
Dash, Ranjeet Prasad; Jayachandra Babu, R.; Srinivas, Nuggehally R.

Therapeutic Potential and Utility of Elacridar with Respect to P-glycoprotein Inhibition: An Insight from the Published In Vitro, Preclinical and Clinical Studies

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Springer Science and Business Media LLC, 2017

Published in: European Journal of Drug Metabolism and Pharmacokinetics, 42 (2017) 6, Seite 915-933
Chuan Tang, Seng; Nguyen, Luan N.; Sparidans, Rolf W.; Wagenaar, Els; Beijnen, Jos H.; Schinkel, Alfred H.

Increased oral availability and brain accumulation of the ALK inhibitor crizotinib by coadministration of the P‐glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2) inhibitor elacridar

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Wiley, 2014

Published in: International Journal of Cancer, 134 (2014) 6, Seite 1484-1494
Sato, Hiromi; Siddig, Sana; Suzuki, Rina; Uzu, Miaki; Suzuki, Sayumi; Nomura, Yuki; Sekine, Yuko; Uehara, Tomoya; Arano, Yasushi; Ueno, Koichi

Abstract 983: A dual inhibitor of MDR-1 and ABCG2,elacridar, enhances cytotoxic effects of sunitinib on RCC cell lines

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American Association for Cancer Research (AACR), 2013

Published in: Cancer Research, 73 (2013) 8_Supplement, Seite 983-983
Bauer, Martin; Karch, Rudolf; Zeitlinger, Markus; Stanek, Johann; Philippe, Cécile; Wadsak, Wolfgang; Mitterhauser, Markus; Jäger, Walter; Haslacher, Helmuth; Müller, Markus; Langer, Oliver

Interaction of 11C-Tariquidar and 11C-Elacridar with P-Glycoprotein and Breast Cancer Resistance Protein at the Human Blood–Brain Barrier

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Society of Nuclear Medicine, 2013

Published in: Journal of Nuclear Medicine, 54 (2013) 8, Seite 1181-1187
Sane, Ramola; Agarwal, Sagar; Mittapalli, Rajendar K.; Elmquist, William F.

Saturable Active Efflux by P-Glycoprotein and Breast Cancer Resistance Protein at the Blood-Brain Barrier Leads to Nonlinear Distribution of Elacridar to the Central Nervous System

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American Society for Pharmacology & Experimental Therapeutics (ASPET), 2013

Published in: Journal of Pharmacology and Experimental Therapeutics, 345 (2013) 1, Seite 111-124
Tang, Seng Chuan; Lagas, Jurjen S.; Lankheet, Nienke A.G.; Poller, Birk; Hillebrand, Michel J.; Rosing, Hilde; Beijnen, Jos H.; Schinkel, Alfred H.

Brain accumulation of sunitinib is restricted by P‐glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2) and can be enhanced by oral elacridar and sunitinib coadministration

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Wiley, 2012

Published in: International Journal of Cancer, 130 (2012) 1, Seite 223-233

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