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  3. Gregson, Stephen J.; Pugh, Kathryn; Patel, Neki; Afif-Rider, Shameen; Vijayakrishnan, Balakumar; Santos, Kathleen; Riedl, Jitka; Hutchinson, Ian; Kang, Gyoung-Dong; Chooi, K. Phin; Beard, Rhiannon; Adams, Lauren; Barry, Conor S.; Ball, Kathryn; Masterson, Luke A.; McFarlane, Mary; Hartley, John A.; Howard, Philip W.

    Efficacy, Tolerability, and Pharmacokinetic Studies of Antibody–Drug Conjugates Containing a Low-Potency Pyrrolobenzodiazepine Dimer

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    American Association for Cancer Research (AACR), 2022

    Published in: Molecular Cancer Therapeutics

  6. Picconi, Pietro; Hind, Charlotte K.; Nahar, Kazi S.; Jamshidi, Shirin; Di Maggio, Lucia; Saeed, Naima; Evans, Bonnie; Solomons, Jessica; Wand, Matthew E.; Sutton, J. Mark; Rahman, Khondaker Miraz

    New Broad-Spectrum Antibiotics Containing a Pyrrolobenzodiazepine Ring with Activity against Multidrug-Resistant Gram-Negative Bacteria

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    American Chemical Society (ACS), 2020

    Published in: Journal of Medicinal Chemistry

  11. Pei, Zhonghua; Chen, Chunjiao; Chen, Jinhua; Cruz-Chuh, Josefa dela; Delarosa, Reginald; Deng, Yuzhong; Fourie-O’Donohue, Aimee; Figueroa, Isabel; Guo, Jun; Jin, Weiwei; Khojasteh, S. Cyrus; Kozak, Katherine R.; Latifi, Brandon; Lee, James; Li, Guangmin; Lin, Eva; Liu, Liling; Lu, Jiawei; Martin, Scott; Ng, Carl; Nguyen, Trung; Ohri, Rachana; Lewis Phillips, Gail; Pillow, Thomas H.; [...]

    Exploration of Pyrrolobenzodiazepine (PBD)-Dimers Containing Disulfide-Based Prodrugs as Payloads for Antibody–Drug Conjugates

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    American Chemical Society (ACS), 2018

    Published in: Molecular Pharmaceutics

  14. Rios-Doria, Jonathan; Harper, Jay; Rothstein, Raymond; Wetzel, Leslie; Chesebrough, Jon; Marrero, Allison; Chen, Cui; Strout, Patrick; Mulgrew, Kathy; McGlinchey, Kelly; Fleming, Ryan; Bezabeh, Binyam; Meekin, John; Stewart, David; Kennedy, Maureen; Martin, Philip; Buchanan, Andrew; Dimasi, Nazzareno; Michelotti, Emil; Hollingsworth, Robert

    Antibody–Drug Conjugates Bearing Pyrrolobenzodiazepine or Tubulysin Payloads Are Immunomodulatory and Synergize with Multiple Immunotherapies

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    American Association for Cancer Research (AACR), 2017

    Published in: Cancer Research

  17. Hinrichs, Mary Jane Masson; Ryan, Pauline M.; Zheng, Bo; Afif-Rider, Shameen; Yu, Xiang Qing; Gunsior, Michele; Zhong, Haihong; Harper, Jay; Bezabeh, Binyam; Vashisht, Kapil; Rebelatto, Marlon; Reed, Molly; Ryan, Patricia C.; Breen, Shannon; Patel, Neki; Chen, Cui; Masterson, Luke; Tiberghien, Arnaud; Howard, Phillip W.; Dimasi, Nazzareno; Dixit, Rakesh

    Fractionated Dosing Improves Preclinical Therapeutic Index of Pyrrolobenzodiazepine-Containing Antibody Drug Conjugates

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    American Association for Cancer Research (AACR), 2017

    Published in: Clinical Cancer Research

  18. Vlahov, Iontcho R.; Qi, Longwu; Kleindl, Paul J.; Santhapuram, Hari K.; Felten, Albert; Parham, Garth L.; Wang, Kevin; You, Fei; Vaughn, Jeremy F.; Hahn, Spencer J.; Klein, Hanna F.; Vetzel, Marilynn; Reddy, Joseph A.; Nelson, Melissa; Nicoson, Jeff; Leamon, Christopher P.

    Latent Warheads for Targeted Cancer Therapy: Design and Synthesis of pro-Pyrrolobenzodiazepines and Conjugates

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    American Chemical Society (ACS), 2017

    Published in: Bioconjugate Chemistry

  19. Pillow, Thomas H.; Schutten, Melissa; Yu, Shang-Fan; Ohri, Rachana; Sadowsky, Jack; Poon, Kirsten Achilles; Solis, Willy; Zhong, Fiona; Del Rosario, Geoffrey; Go, Mary Ann T.; Lau, Jeffrey; Yee, Sharon; He, Jintang; Liu, Luna; Ng, Carl; Xu, Keyang; Leipold, Douglas D.; Kamath, Amrita V.; Zhang, Donglu; Masterson, Luke; Gregson, Stephen J.; Howard, Philip W.; Fang, Fan; Chen, Jinhua; [...]

    Modulating Therapeutic Activity and Toxicity of Pyrrolobenzodiazepine Antibody–Drug Conjugates with Self-Immolative Disulfide Linkers

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    American Association for Cancer Research (AACR), 2017

    Published in: Molecular Cancer Therapeutics

  20. Pertejo, Pablo; Peña-Calleja, Pablo; Carreira-Barral, Israel; Quesada, Roberto; Alejandro Cordero, Nicolás; Javier Rodríguez, Francisco; García-Valverde, María

    Novel pyrrolobenzodiazepine and pyrroloquinazoline scaffolds synthesized by a simple and highly selective Ugi/cyclization sequence

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    Royal Society of Chemistry (RSC), 2017

    Published in: Organic & Biomolecular Chemistry