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Jung, Manfred; Chakrabarti, Alokta; Heimbach, Tino; Sippl, Wolfgang; Marek, Martin; Romier, Christophe; Oehme, Ina; Witt, Olaf

Abstract B80: New inhibitors of histone deacetylase 8 (HDAC8) as anticancer agents

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American Association for Cancer Research (AACR), 2015

Published in: Molecular Cancer Therapeutics
Deubzer, Hedwig E.; Schier, Marie C.; Oehme, Ina; Lodrini, Marco; Haendler, Bernard; Sommer, Anette; Witt, Olaf

HDAC11 is a novel drug target in carcinomas

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Wiley, 2013

Published in: International Journal of Cancer
Wegener, Dennis; Deubzer, Hedwig E.; Oehme, Ina; Milde, Till; Hildmann, Christian; Schwienhorst, Andreas; Witt, Olaf

HKI 46F08, a novel potent histone deacetylase inhibitor, exhibits antitumoral activity against embryonic childhood cancer cells

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Ovid Technologies (Wolters Kluwer Health), 2008

Published in: Anti-Cancer Drugs
Seiboldt, Till; Zeiser, Constantia; Salem-Altintas, Rabia; Nguyen, Duy; Holland-Letz, Tim; Peterziel, Heike; Witt, Olaf; Oehme, Ina

MODL-15. High-throughput combination drug screening identifies synergism between retinoic acid treatment and BCL-XL-inhibition in MYC(N)-driven medulloblastoma and neuroblastoma models

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Oxford University Press (OUP), 2022

Published in: Neuro-Oncology
ElHarouni, Dina; Peterziel, Heike; Schramm, Kathrin; Milde, Till; Oppermann, Sina; Oehme, Ina; Witt, Olaf; Schlesner, Matthias; Jäger, Natalie

Multiomics analysis of pediatric solid tumors within the INFORM precision oncology study: From functional drug profiling to biomarker identification

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American Society of Clinical Oncology (ASCO), 2022

Published in: Journal of Clinical Oncology
Berker, Yannick; ElHarouni, Dina; Peterziel, Heike; Fiesel, Petra; Witt, Olaf; Oehme, Ina; Schlesner, Matthias; Oppermann, Sina

Patient-by-Patient Deep Transfer Learning for Drug-Response Profiling Using Confocal Fluorescence Microscopy of Pediatric Patient-Derived Tumor-Cell Spheroids

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Institute of Electrical and Electronics Engineers (IEEE), 2022

Published in: IEEE Transactions on Medical Imaging
Vollmer, Johanna; Ecker, Jonas; Hielscher, Thomas; Valinciute, Gintvile; Oppermann, Sina; Peterziel, Heike; Oehme, Ina; Witt, Olaf; Milde, Till

MBRS-19. SYNERGISM OF HDAC AND PARP INHIBITORS IN MYC-DRIVEN GROUP 3 MEDULLOBLASTOMA CELLS

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Oxford University Press (OUP), 2020

Published in: Neuro-Oncology
Fiegler, Nathalie; Textor, Sonja; Arnold, Annette; Rölle, Alexander; Oehme, Ina; Breuhahn, Kai; Moldenhauer, Gerhard; Witzens-Harig, Mathias; Cerwenka, Adelheid

Downregulation of the activating NKp30 ligand B7-H6 by HDAC inhibitors impairs tumor cell recognition by NK cells

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American Society of Hematology, 2013

Published in: Blood
Dovzhanskiy, Dmitriy I; Arnold, Stefanie M; Hackert, Thilo; Oehme, Ina; Witt, Olaf; Felix, Klaus; Giese, Nathalia; Werner, Jens

Experimental in vivo and in vitro treatment with a new histone deacetylase inhibitor belinostat inhibits the growth of pancreatic cancer

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Springer Science and Business Media LLC, 2012

Published in: BMC Cancer
Böck, Barbara C.; Tagscherer, Katrin E.; Fassl, Anne; Krämer, Anika; Oehme, Ina; Zentgraf, Hans-Walter; Keith, Martina; Roth, Wilfried

The PEA-15 Protein Regulates Autophagy via Activation of JNK

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Elsevier BV, 2010

Published in: Journal of Biological Chemistry
Zeuner, Simon; Vollmer, Johanna; Sigaud, Romain; Oppermann, Sina; Peterziel, Heike; ElHarouni, Dina; Oehme, Ina; Witt, Olaf; Milde, Till; Ecker, Jonas

Combination drug screen identifies synergistic drug interaction of BCL-XL and class I histone deacetylase inhibitors in MYC-amplified medulloblastoma cells

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Springer Science and Business Media LLC, 2024

Published in: Journal of Neuro-Oncology
Rösch, Lisa; Herter, Sonja; Najafi, Sara; Ridinger, Johannes; Peterziel, Heike; Cinatl, Jindrich; Jones, David T. W.; Michaelis, Martin; Witt, Olaf; Oehme, Ina

ERBB and P‐glycoprotein inhibitors break resistance in relapsed neuroblastoma models through P‐glycoprotein

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Wiley, 2023

Published in: Molecular Oncology
Vollmer, Johanna; Ecker, Jonas; Hielscher, Thomas; Valinciute, Gintvile; Ridinger, Johannes; Jamaladdin, Nora; Peterziel, Heike; van Tilburg, Cornelis M.; Oehme, Ina; Witt, Olaf; Milde, Till

Class I HDAC inhibition reduces DNA damage repair capacity of MYC-amplified medulloblastoma cells

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Springer Science and Business Media LLC, 2023

Published in: Journal of Neuro-Oncology
Jamaladdin, Nora; Peterziel, Heike; ElHarouni, Dina; Jäger, Natalie; Holland-Letz, Tim; Kopp-Schneider, Annette; Sigaud, Romain; Witt, Olaf; Oehme, Ina; Milde, Till

DDEL-01. The role of key pharmacodynamic and pharmacokinetic parameters in drug response prediction of pediatric tumors in the precision oncology study INFORM

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Oxford University Press (OUP), 2022

Published in: Neuro-Oncology
Krausert, Sonja; Mack, Norman; Schwalm, Benjamin; Peterziel, Heike; Oehme, Ina; van Tilburg, Cornelis M; Witt, Olaf; Pfister, Stefan M; Kool, Marcel

MODL-01. Targeting replication stress in pediatric brain tumors

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Oxford University Press (OUP), 2022

Published in: Neuro-Oncology
Körholz, Katharina; Ridinger, Johannes; Krunic, Damir; Najafi, Sara; Gerloff, Xenia F.; Frese, Karen; Meder, Benjamin; Peterziel, Heike; Vega-Rubin-de-Celis, Silvia; Witt, Olaf; Oehme, Ina

Broad-Spectrum HDAC Inhibitors Promote Autophagy through FOXO Transcription Factors in Neuroblastoma

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MDPI AG, 2021

Published in: Cells
Zeuner, Simon; Vollmer, Johanna; Peterziel, Heike; Sigaud, Romain; Oppermann, Sina; ElHarouni, Dina; Hielscher, Thomas; Witt, Olaf; Oehme, Ina; Milde, Till; Ecker, Jonas

EMBR-11. SYNERGISTIC DRUG COMBINATIONS FOR THE TREATMENT OF MYC AMPLIFIED GROUP 3 MEDULLOBLASTOMA

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Oxford University Press (OUP), 2021

Published in: Neuro-Oncology
Wrobel, Jagoda K; Najafi, Sara; Ayhan, Simay; Gatzweiler, Charlotte; Krunic, Damir; Ridinger, Johannes; Milde, Till; Westermann, Frank; Peterziel, Heike; Meder, Benjamin; Distel, Martin; Witt, Olaf; Oehme, Ina

Rapid In Vivo Validation of HDAC Inhibitor-Based Treatments in Neuroblastoma Zebrafish Xenografts

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MDPI AG, 2020

Published in: Pharmaceuticals
Kolbinger, Fiona R.; Koeneke, Emily; Ridinger, Johannes; Heimburg, Tino; Müller, Michael; Bayer, Theresa; Sippl, Wolfgang; Jung, Manfred; Gunkel, Nikolas; Miller, Aubry K.; Westermann, Frank; Witt, Olaf; Oehme, Ina

The HDAC6/8/10 inhibitor TH34 induces DNA damage-mediated cell death in human high-grade neuroblastoma cell lines

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Springer Science and Business Media LLC, 2018

Published in: Archives of Toxicology
Ecker, Jonas; Oehme, Ina; Selt, Florian; Kool, Marcel; Schnölzer, Martina; Warnken, Uwe; Brabetz, Sebastian; Wechsler-Reya, Robert; Kulozik, Andreas E.; Pfister, Stefan M.; Witt, Olaf; Milde, Till

MB-57INTERACTION OF HDAC2 AND MYC IN GROUP 3 MEDULLOBLASTOMA - A NOVEL THERAPEUTIC TARGET

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Oxford University Press (OUP), 2016

Published in: Neuro-Oncology

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