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Krug, Anne K. [Author]; Kolde, Raivo [Author]; Gaspar, John A. [Author]; Rempel, Eugen [Author]; Balmer, Nina V. [Author]; Meganathan, Kesavan [Author]; Vojnits, Kinga [Author]; Baquié, Mathurin [Author]; Waldmann, Tanja [Author]; Ensenat-Waser, Roberto [Author]; Jagtap, Smita [Author]; Evans, Richard M. [Author]; Julien, Stephanie [Author]; Peterson, Hedi [Author]; Zagoura, Dimitra [Author]; Kadereit, Suzanne [Author]; Gerhard, Daniel [Author]; Sotiriadou, Isaia [Author]; Heke, Michael [Author]; Natarajan, Karthick [Author]; Henry, Margit [Author]; Winkler, Johannes [Author]; Marchan, Rosemarie [Author]; Stoppini, Luc [Author]; [...]

Human embryonic stem cell-derived test systems for developmental neurotoxicity: A transcriptomics approach - [published Version]

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Heidelberg : Springer Verlag, 2013

Published in: Archives of Toxicology 87 (2013), Nr. 1
Bellmann, Susann; Minekus, Mans; Sanders, Peter; Bosgra, Sieto; Havenaar, Robert

Human glycemic response curves after intake of carbohydrate foods are accurately predicted by combining in vitro gastrointestinal digestion with in silico kinetic modeling

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Elsevier BV, 2018

Published in: Clinical Nutrition Experimental, 17 (2018), Seite 8-22
Bosgra, Sieto; Vlaming, Maria L. H.; Vaes, Wouter H. J.

To Apply Microdosing or Not? Recommendations to Single Out Compounds with Non-Linear Pharmacokinetics

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Springer Science and Business Media LLC, 2016

Published in: Clinical Pharmacokinetics, 55 (2016) 1, Seite 1-15
Bosgra, Sieto; van Eijkeren, Jan C. H.; Slob, Wout

Dose addition and the isobole method as approaches for predicting the cumulative effect of non-interacting chemicals: A critical evaluation

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Informa UK Limited, 2009

Published in: Critical Reviews in Toxicology, 39 (2009) 5, Seite 418-426
Kátai, Csaba B.; Smithline, Shepard J.; Thalhauser, Craig J.; Bosgra, Sieto; Elassaiss-Schaap, Jeroen

An asymptotic description of a basic FcRn-regulated clearance mechanism and its implications for PBPK modelling of large antibodies

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Springer Science and Business Media LLC, 2024

Published in: Journal of Pharmacokinetics and Pharmacodynamics (2024)
van Putten, Maaike; Tanganyika-de Winter, Christa; Bosgra, Sieto; Aartsma-Rus, Annemieke

Nonclinical Exon Skipping Studies with 2′-O-Methyl Phosphorothioate Antisense Oligonucleotides in mdx and mdx-utrn−/− Mice Inspired by Clinical Trial Results

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Mary Ann Liebert Inc, 2019

Published in: Nucleic Acid Therapeutics, 29 (2019) 2, Seite 92-103
Bosgra, Sieto; Sipkens, Jessica; de Kimpe, Sjef; den Besten, Cathaline; Datson, Nicole; van Deutekom, Judith

The Pharmacokinetics of 2′-O-Methyl Phosphorothioate Antisense Oligonucleotides: Experiences from Developing Exon Skipping Therapies for Duchenne Muscular Dystrophy

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Mary Ann Liebert Inc, 2019

Published in: Nucleic Acid Therapeutics, 29 (2019) 6, Seite 305-322
Louisse, Jochem; Bosgra, Sieto; Blaauboer, Bas J.; Rietjens, Ivonne M. C. M.; Verwei, Miriam

Prediction of in vivo developmental toxicity of all-trans-retinoic acid based on in vitro toxicity data and in silico physiologically based kinetic modeling

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Springer Science and Business Media LLC, 2015

Published in: Archives of Toxicology, 89 (2015) 7, Seite 1135-1148
Bosgra, Sieto; van Eijkeren, Jan; Bos, Peter; Zeilmaker, Marco; Slob, Wout

An improved model to predict physiologically based model parameters and their inter-individual variability from anthropometry

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Informa UK Limited, 2012

Published in: Critical Reviews in Toxicology, 42 (2012) 9, Seite 751-767
Oomen, Agnes G.; Tolls, Johannes; Kruidenier, Maaike; Bosgra, Sieto S. D.; Sips, Adrienne J. A. M.; Groten, John P.

Availability of Polychlorinated Biphenyls (PCBs) and Lindane for Uptake by Intestinal Caco-2 Cells

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JSTOR, 2001

Published in: Environmental Health Perspectives, 109 (2001) 7, Seite 731
Hiemstra, Ida H.; Santegoets, Kim; Janmaat, Maarten; Ten Hagen, Wessel; Sanchez, Rosanna; Brady, Lauren; Bosgra, Sieto; Overdijk, Marije; Chen, Jenny; Fladeland Iversen, Katrine; Plesner, Torben; Breij, Esther

P816: PHARMACODYNAMIC ACTIVITY OF GEN3014 (HEXABODY-CD38) IN PATIENTS WITH MULTIPLE MYELOMA SUPPORTS ENHANCED COMPLEMENT DEPENDENT CYTOTOXICITY OF GEN3014 COMPARED TO DARATUMUMAB

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Wiley, 2023

Published in: HemaSphere, 7 (2023) S3, Seite e008261b
Kourkouta, Eleni; Weij, Rudie; González-Barriga, Anchel; Mulder, Melissa; Verheul, Ruurd; Bosgra, Sieto; Groenendaal, Bas; Puoliväli, Jukka; Toivanen, Jussi; van Deutekom, Judith C.T.; Datson, Nicole A.

Suppression of Mutant Protein Expression in SCA3 and SCA1 Mice Using a CAG Repeat-Targeting Antisense Oligonucleotide

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Elsevier BV, 2019

Published in: Molecular Therapy - Nucleic Acids, 17 (2019), Seite 601-614
Colaianna, Marilena; Ilmjärv, Sten; Peterson, Hedi; Kern, Ilse; Julien, Stephanie; Baquié, Mathurin; Pallocca, Giorgia; Bosgra, Sieto; Sachinidis, Agapios; Hengstler, Jan G.; Leist, Marcel; Krause, Karl-Heinz

Fingerprinting of neurotoxic compounds using a mouse embryonic stem cell dual luminescence reporter assay

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Springer Science and Business Media LLC, 2017

Published in: Archives of Toxicology, 91 (2017) 1, Seite 365-391
Berman, Cindy L.; Antonsson, Madeleine; Batkai, Sandor; Bosgra, Sieto; Chopda, Girish R.; Driessen, Wouter; Foy, Jeffrey; Hassan, Chopie; Hu, Xiao Shelley; Jang, Hyun Gyung; Meena; Sanseverino, Mark; Thum, Thomas; Wang, Yanfeng; Wild, Martin; Wu, Jing-Tao

OSWG Recommended Approaches to the Nonclinical Pharmacokinetic (ADME) Characterization of Therapeutic Oligonucleotides

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Mary Ann Liebert Inc, 2023

Published in: Nucleic Acid Therapeutics, 33 (2023) 5, Seite 287-305
Hiemstra, Ida H; Janmaat, Maarten L; Boross, Peter; van den Brakel, Jeroen; ten Hagen, Wessel; van Dooremalen, Sanne; Bosgra, Sieto; De Goeij, Bart ECG; Andringa, Grietje; Kil, Laurens; Sasser, A Kate; Ahmadi, Tahamtan; Satijn, David; Breij, Esther CW

Preclinical Anti-Tumor Activity of Hexabody-CD38 in Patient-Derived B Cell Lymphoma and Acute Myeloid Leukemia Xenograft Models

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American Society of Hematology, 2020

Published in: Blood, 136 (2020) Supplement 1, Seite 19-20
de Ligt, Rianne; van Duijn, Esther; Grossouw, Dimitri; Bosgra, Sieto; Burggraaf, Jacobus; Windhorst, Albert; Peeters, Pierre A.M.; van der Luijt, Gerrit A.; Alexander‐White, Camilla; Vaes, Wouter H.J.

Assessment of Dermal Absorption of Aluminum from a Representative Antiperspirant Formulation Using a 26Al Microtracer Approach

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Wiley, 2018

Published in: Clinical and Translational Science, 11 (2018) 6, Seite 573-581
Wambaugh, John F.; Wetmore, Barbara A.; Pearce, Robert; Strope, Cory; Goldsmith, Rocky; Sluka, James P.; Sedykh, Alexander; Tropsha, Alex; Bosgra, Sieto; Shah, Imran; Judson, Richard; Thomas, Russell S.; Setzer, R. Woodrow

Toxicokinetic Triage for Environmental Chemicals

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Oxford University Press (OUP), 2015

Published in: Toxicological Sciences, 147 (2015) 1, Seite 55-67
van Deutekom, Judith; Beekman, Chantal; Bijl, Suzanne; Bosgra, Sieto; van den Eijnde, Rani; Franken, Dennis; Groenendaal, Bas; Harquouli, Bouchra; Janson, Anneke; Koevoets, Paul; Mulder, Melissa; Muilwijk, Daan; Peterburgska, Galyna; Querido, Bianca; Testerink, Janwillem; Verheul, Ruurd; de Visser, Peter; Weij, Rudie; Aartsma-Rus, Annemieke; Puoliväli, Jukka; Bragge, Timo; O'Neill, Charles; Datson, Nicole A.

Next Generation Exon 51 Skipping Antisense Oligonucleotides for Duchenne Muscular Dystrophy

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Mary Ann Liebert Inc, 2023

Published in: Nucleic Acid Therapeutics, 33 (2023) 3, Seite 193-208
Hiemstra, Ida H.; Santegoets, Kim C.M.; Janmaat, Maarten L.; De Goeij, Bart E.C.G.; Ten Hagen, Wessel; van Dooremalen, Sanne; Boross, Peter; van den Brakel, Jeroen; Bosgra, Sieto; Andringa, Grietje; van Kessel-Welmers, Berris; Verzijl, Dennis; Hibbert, Richard G.; Frerichs, Kristine A.; Mutis, Tuna; van de Donk, Niels W.C.J.; Ahmadi, Tahamtan; Satijn, David; Sasser, A. Kate; Breij, Esther C.W.

Preclinical anti-tumour activity of HexaBody-CD38, a next-generation CD38 antibody with superior complement-dependent cytotoxic activity

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Elsevier BV, 2023

Published in: eBioMedicine, 93 (2023), Seite 104663
Spencer, Andrew; Iversen, Katrine Fladeland; Dhakal, Binod; Creignou, Maria; Chen, Jenny; Hiemstra, Ida H; Bosgra, Sieto; Badani, Avani; Breij, Esther C.W.; Brady, Lauren K.; Sasser, A. Kate; Malmberg, Anders; Gregersen, Henrik; Hansson, Markus; Broijl, Annemiek; Mateos, Maria-Victoria; Plesner, Torben

Preliminary Dose-Escalation Results from a Phase 1/2 Study of GEN3014 (HexaBody®-CD38) in Patients (pts) with Relapsed or Refractory Multiple Myeloma (RRMM)

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American Society of Hematology, 2022

Published in: Blood, 140 (2022) Supplement 1, Seite 7320-7321

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