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Bosbach, Benedikt [Author]

Modeling Oncogenic KIT Signaling and Drug Resistance in the Mouse

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Konstanz: Bibliothek der Universität Konstanz, 2012
Bosbach, Benedikt [Author]

Modeling Oncogenic KIT Signaling and Drug Resistance in the Mouse

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2012
Tschaharganeh, Darjus F.; Bosbach, Benedikt; Lowe, Scott W.

Coordinated Tumor Suppression by Chromosome 8p

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Elsevier BV, 2016

Published in: Cancer Cell, 29 (2016) 5, Seite 617-619
Zhang, Jennifer Q.; Bosbach, Benedikt; Antonescu, Cristina; Besmer, Peter; DeMatteo, Ronald

Abstract 1038: The KIT-V654A second site mutation confers perinatal lethality and increased oncogenesis in a mouse model of GIST

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American Association for Cancer Research (AACR), 2017

Published in: Cancer Research, 77 (2017) 13_Supplement, Seite 1038-1038
Klobes, Benedikt; Finkeldei, Sarah; Brandt, Felix; Bosbach, Dirk; Bessas, Dimitrios; Embs, Jan‐Peter; Hermann, Raphaël P.

A general and Eu specific perspective on lattice dynamics in pyrochlore and defect fluorite (EuNd)ZrO

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Wiley, 2015

Published in: physica status solidi (b), 252 (2015) 9, Seite 1940-1645
Deshpande, Shayu; Bosbach, Benedikt; Yozgat, Yasemin; Park, Christopher Y.; Moore, Malcolm A.S.; Besmer, Peter

KIT Receptor Gain-of-Function in Hematopoiesis Enhances Stem Cell Self-Renewal and Promotes Progenitor Cell Expansion

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Oxford University Press (OUP), 2013

Published in: Stem Cells, 31 (2013) 8, Seite 1683-1695
Saborowski, Michael; Saborowski, Anna; Morris, John P.; Bosbach, Benedikt; Dow, Lukas E.; Pelletier, Jerry; Klimstra, David S.; Lowe, Scott W.

A modular and flexible ESC-based mouse model of pancreatic cancer

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Cold Spring Harbor Laboratory, 2014

Published in: Genes & Development, 28 (2014) 1, Seite 85-97
Zhang, Hua; Risal, Sanjiv; Gorre, Nagaraju; Busayavalasa, Kiran; Li, Xin; Shen, Yan; Bosbach, Benedikt; Brännström, Mats; Liu, Kui

Somatic Cells Initiate Primordial Follicle Activation and Govern the Development of Dormant Oocytes in Mice

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Elsevier BV, 2014

Published in: Current Biology, 24 (2014) 21, Seite 2501-2508
Orris, Benjamin; Sung, Min Woo; Bhat, Shridhar; Xu, Yingrong; Huynh, Kevin W; Han, Seungil; Johnson, Darren C; Bosbach, Benedikt; Shields, David J; Stivers, James T

Guanine-containing ssDNA and RNA induce dimeric and tetrameric structural forms of SAMHD1

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Oxford University Press (OUP), 2023

Published in: Nucleic Acids Research, 51 (2023) 22, Seite 12443-12458
Orris, Benjamin; Huynh, Kevin W; Ammirati, Mark; Han, Seungil; Bolaños, Ben; Carmody, Jason; Petroski, Matthew D; Bosbach, Benedikt; Shields, David J; Stivers, James T

Phosphorylation of SAMHD1 Thr592 increases C-terminal domain dynamics, tetramer dissociation and ssDNA binding kinetics

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Oxford University Press (OUP), 2022

Published in: Nucleic Acids Research, 50 (2022) 13, Seite 7545-7559
Veeneman, Brendan; Gao, Ying; Grant, Joy; Fruhling, David; Ahn, James; Bosbach, Benedikt; Bienkowska, Jadwiga; Follettie, Maximillian; Arndt, Kim; Myers, Jeremy; Zhong, Wenyan

PINCER: improved CRISPR/Cas9 screening by efficient cleavage at conserved residues

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Oxford University Press (OUP), 2020

Published in: Nucleic Acids Research, 48 (2020) 17, Seite 9462-9477
Zhang, Jennifer Q.; Bosbach, Benedikt; Loo, Jennifer K.; Vitiello, Gerardo A.; Zeng, Shan; Seifert, Adrian M.; Medina, Benjamin D.; Param, Nesteene J.; Maltbaek, Joanna H.; Rossi, Ferdinand; Antonescu, Cristina R.; Besmer, Peter; DeMatteo, Ronald P.

The V654A second-site KIT mutation increases tumor oncogenesis and STAT activation in a mouse model of gastrointestinal stromal tumor

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Springer Science and Business Media LLC, 2020

Published in: Oncogene, 39 (2020) 49, Seite 7153-7165
Kastenhuber, Edward R.; Lalazar, Gadi; Houlihan, Shauna L.; Tschaharganeh, Darjus F.; Baslan, Timour; Chen, Chi-Chao; Requena, David; Tian, Sha; Bosbach, Benedikt; Wilkinson, John E.; Simon, Sanford M.; Lowe, Scott W.

DNAJB1–PRKACA fusion kinase interacts with β-catenin and the liver regenerative response to drive fibrolamellar hepatocellular carcinoma

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Proceedings of the National Academy of Sciences, 2017

Published in: Proceedings of the National Academy of Sciences, 114 (2017) 50, Seite 13076-13084
Bosbach, Benedikt; Rossi, Ferdinand; Yozgat, Yasemin; Loo, Jennifer; Zhang, Jennifer Q.; Berrozpe, Georgina; Warpinski, Katherine; Ehlers, Imke; Veach, Darren; Kwok, Andrew; Manova, Katia; Antonescu, Cristina R.; DeMatteo, Ronald P.; Besmer, Peter

Direct engagement of the PI3K pathway by mutant KIT dominates oncogenic signaling in gastrointestinal stromal tumor

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Proceedings of the National Academy of Sciences, 2017

Published in: Proceedings of the National Academy of Sciences, 114 (2017) 40
Bosbach, Benedikt; Rossi, Ferdinand; Yozgat, Yasemin; Loo, Jennifer; Zhang, Jennifer Q.; Berrozpe, Georgina; Warpinski, Katherine; Ehlers, Imke; Veach, Darren; Kwok, Andrew; Manova, Katia; Antonescu, Cristina R.; DeMatteo, Ronald P.; Besmer, Peter

Direct engagement of the PI3K pathway by mutant KIT dominates oncogenic signaling in gastrointestinal stromal tumor

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National Academy of Sciences, 2017

Published in: Proceedings of the National Academy of Sciences of the United States of America, 114 (2017) 40, Seite E8448-E8457
Kastenhuber, Edward R.; Lalazar, Gadi; Houlihan, Shauna L.; Tschaharganeh, Darjus F.; Baslan, Timour; Chen, Chi-Chao; Requena, David; Tian, Sha; Bosbach, Benedikt; Wilkinson, John E.; Simon, Sanford M.; Lowe, Scott W.

DNAJB1–PRKACA fusion kinase interacts with β-catenin and the liver regenerative response to drive fibrolamellar hepatocellular carcinoma

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National Academy of Sciences, 2017

Published in: Proceedings of the National Academy of Sciences of the United States of America, 114 (2017) 50, Seite 13076-13084
Miething, Cornelius; Scuoppo, Claudio; Bosbach, Benedikt; Appelmann, Iris; Nakitandwe, Joy; Ma, Jing; Wu, Gang; Lintault, Laura; Auer, Martina; Premsrirut, Prem K.; Teruya-Feldstein, Julie; Hicks, James; Benveniste, Helene; Speicher, Michael R.; Downing, James R.; Lowe, Scott W.

PTEN action in leukaemia dictated by the tissue microenvironment

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Springer Science and Business Media LLC, 2014

Published in: Nature, 510 (2014) 7505, Seite 402-406
Bosbach, Benedikt; Deshpande, Shayu; Rossi, Ferdinand; Shieh, Jae-Hung; Sommer, Gunhild; de Stanchina, Elisa; Veach, Darren R.; Scandura, Joseph M.; Manova-Todorova, Katia; Moore, Malcolm A. S.; Antonescu, Cristina R.; Besmer, Peter

Imatinib resistance and microcytic erythrocytosis in a Kit V558Δ;T669I/+ gatekeeper-mutant mouse model of gastrointestinal stromal tumor

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Proceedings of the National Academy of Sciences, 2012

Published in: Proceedings of the National Academy of Sciences, 109 (2012) 34
Skamagki, Maria; Correia, Cristina; Yeung, Percy; Baslan, Timour; Beck, Samuel; Zhang, Cheng; Ross, Christian A.; Dang, Lam; Liu, Zhong; Giunta, Simona; Chang, Tzu-Pei; Wang, Joye; Ananthanarayanan, Aparna; Bohndorf, Martina; Bosbach, Benedikt; Adjaye, James; Funabiki, Hironori; Kim, Jonghwan; Lowe, Scott; Collins, James J.; Lu, Chi-Wei; Li, Hu; Zhao, Rui; Kim, Kitai

Author Correction: ZSCAN10 expression corrects the genomic instability of iPSCs from aged donors

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Springer Science and Business Media LLC, 2019

Published in: Nature Cell Biology, 21 (2019) 4, Seite 531-532
Skamagki, Maria; Correia, Cristina; Yeung, Percy; Baslan, Timour; Beck, Samuel; Zhang, Cheng; Ross, Christian A.; Dang, Lam; Liu, Zhong; Giunta, Simona; Chang, Tzu-Pei; Wang, Joye; Ananthanarayanan, Aparna; Bohndorf, Martina; Bosbach, Benedikt; Adjaye, James; Funabiki, Hironori; Kim, Jonghwan; Lowe, Scott; Collins, James J.; Lu, Chi-Wei; Li, Hu; Zhao, Rui; Kim, Kitai

ZSCAN10 expression corrects the genomic instability of iPSCs from aged donors

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Springer Science and Business Media LLC, 2017

Published in: Nature Cell Biology, 19 (2017) 9, Seite 1037-1048

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