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Hammouda, Omar [Author]; Wu, Meng Yue [Author]; Kaul, Verena [Author]; Gierten, Jakob [Author]; Thumberger, Thomas [Author]; Wittbrodt, Joachim [Author]

In vivo identification and validation of novel potential predictors for human cardiovascular diseases

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June 21, 2021

Published in: bioRxiv beta ; (2021) vom: Juni, Artikel-ID 2021.02.03.429563, Seite 1-42
Cornean, Alex [Author]; Gierten, Jakob [Author]; Welz, Bettina [Author]; Mateo, Juan L. [Author]; Thumberger, Thomas [Author]; Wittbrodt, Joachim [Author]

Precise in vivo functional analysis of DNA variants with base editing using ACEofBASEs target prediction

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July 26, 2021

Published in: bioRxiv beta ; (2021) vom: Juli, Artikel-ID 2021.07.26.453883, Seite 1-63
Gierten, Jakob [Author]; Pylatiuk, Christian [Author]; Hammouda, Omar [Author]; Schock, Christian [Author]; Stegmaier, Johannes [Author]; Wittbrodt, Joachim [Author]; Gehrig, Jochen [Author]; Loosli, Felix [Author]

Automated high-throughput heart rate measurement in medaka and zebrafish embryos under physiological conditions

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Karlsruhe, [2019]
Doering, Lino [Author]; Cornean, Alex [Author]; Thumberger, Thomas [Author]; Benjaminsen, Jørgen [Author]; Wittbrodt, Beate [Author]; Kellner, Tanja [Author]; Hammouda, Omar T. [Author]; Gorenflo, Matthias [Author]; Wittbrodt, Joachim [Author]; Gierten, Jakob [Author]

CRISPR-based knockout and base editing confirm the role of MYRF in heart development and congenital heart disease

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August 2023

Published in: Disease models & mechanisms ; 16(2023), 8 vom: Aug., Artikel-ID dmm049811, Seite 1-14
Fitzgerald, Tomas [Author]; Brettell, Ian [Author]; Leger, Adrien [Author]; Wolf, Nadeshda [Author]; Kusminski, Natalja [Author]; Monahan, Jack [Author]; Barton, Carl [Author]; Herder, Cathrin [Author]; Aadepu, Narendar [Author]; Gierten, Jakob [Author]; Becker, Clara [Author]; Hammouda, Omar [Author]; Hasel, Eva Mareike [Author]; Lischik, Colin Q. [Author]; Lust, Katharina [Author]; Suzuki, Risa [Author]; Tsingos, Erika [Author]; Tavhelidse-Suck, Tinatini [Author]; Thumberger, Thomas [Author]; Watson, Philip [Author]; Welz, Bettina [Author]; Khouja, Nadia [Author]; Naruse, Kiyoshi [Author]; Birney, Ewan [Author]; [...]

The Medaka Inbred Kiyosu-Karlsruhe (MIKK) panel

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May 21, 2021

Published in: bioRxiv beta ; (2021) vom: Mai, Artikel-ID 2021.05.17.444412, Seite 1-34
Cornean, Alex; Gierten, Jakob; Welz, Bettina; Mateo, Juan Luis; Thumberger, Thomas; Wittbrodt, Joachim

Precise in vivo functional analysis of DNA variants with base editing using ACEofBASEs target prediction

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eLife Sciences Publications, Ltd, 2022

Published in: eLife, 11 (2022)
Hammouda, Omar T.; Wu, Meng Yue; Kaul, Verena; Gierten, Jakob; Thumberger, Thomas; Wittbrodt, Joachim

In vivo identification and validation of novel potential predictors for human cardiovascular diseases

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Public Library of Science (PLoS), 2021

Published in: PLOS ONE, 16 (2021) 12, Seite e0261572
Schutera, Mark; Just, Steffen; Gierten, Jakob; Mikut, Ralf; Reischl, Markus; Pylatiuk, Christian

Machine Learning Methods for Automated Quantification of Ventricular Dimensions

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Mary Ann Liebert Inc, 2019

Published in: Zebrafish, 16 (2019) 6, Seite 542-545
Gierten, Jakob; Hassel, David; Schweizer, Patrick A.; Becker, Rüdiger; Katus, Hugo A.; Thomas, Dierk

Identification and functional characterization of zebrafish K2P10.1 (TREK2) two-pore-domain K+ channels

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Elsevier BV, 2012

Published in: Biochimica et Biophysica Acta (BBA) - Biomembranes, 1818 (2012) 1, Seite 33-41
Gierten, Jakob; Pylatiuk, Christian; Hammouda, Omar T.; Schock, Christian; Stegmaier, Johannes; Wittbrodt, Joachim; Gehrig, Jochen; Loosli, Felix

Automated high-throughput heartbeat quantification in medaka and zebrafish embryos under physiological conditions

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Springer Science and Business Media LLC, 2020

Published in: Scientific Reports, 10 (2020) 1
Wagner, Nils; Norlin, Nils; Gierten, Jakob; de Medeiros, Gustavo; Balázs, Bálint; Wittbrodt, Joachim; Hufnagel, Lars; Prevedel, Robert

Instantaneous isotropic volumetric imaging of fast biological processes

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Springer Science and Business Media LLC, 2019

Published in: Nature Methods, 16 (2019) 6, Seite 497-500
Rahm, Ann-Kathrin; Wiedmann, Felix; Gierten, Jakob; Schmidt, Constanze; Schweizer, Patrick A.; Becker, Rüdiger; Katus, Hugo A.; Thomas, Dierk

Functional characterization of zebrafish K2P18.1 (TRESK) two-pore-domain K+ channels

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Springer Science and Business Media LLC, 2014

Published in: Naunyn-Schmiedeberg's Archives of Pharmacology, 387 (2014) 3, Seite 291-300
Gierten, Jakob; Ficker, Eckhard; Bloehs, Ramona; Schweizer, Patrick A.; Zitron, Edgar; Scholz, Eberhard; Karle, Christoph; Katus, Hugo A.; Thomas, Dierk

The human cardiac K2P3.1 (TASK-1) potassium leak channel is a molecular target for the class III antiarrhythmic drug amiodarone

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Springer Science and Business Media LLC, 2010

Published in: Naunyn-Schmiedeberg's Archives of Pharmacology, 381 (2010) 3, Seite 261-270
Gierten, Jakob; Ficker, Eckhard; Bloehs, Ramona; Schlömer, Kathrin; Kathöfer, Sven; Scholz, Eberhard; Zitron, Edgar; Katus, Hugo; Karle, Christoph; Thomas, Dierk

Inhibition of hK2P3.1 (TASK-1) Potassium Channels by the Tyrosine Kinase Inhibitor Genistein

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Elsevier BV, 2009

Published in: Biophysical Journal, 96 (2009) 3, Seite 563a
Doering, Lino; Cornean, Alex; Thumberger, Thomas; Benjaminsen, Joergen; Wittbrodt, Beate; Kellner, Tanja; Hammouda, Omar T.; Gorenflo, Matthias; Wittbrodt, Joachim; Gierten, Jakob

CRISPR-based knockout and base editing confirm the role of MYRF in heart development and congenital heart disease

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The Company of Biologists, 2023

Published in: Disease Models & Mechanisms, 16 (2023) 8
Wagner, Nils; Beuttenmueller, Fynn; Norlin, Nils; Gierten, Jakob; Boffi, Juan Carlos; Wittbrodt, Joachim; Weigert, Martin; Hufnagel, Lars; Prevedel, Robert; Kreshuk, Anna

Deep learning-enhanced light-field imaging with continuous validation

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Springer Science and Business Media LLC, 2021

Published in: Nature Methods, 18 (2021) 5, Seite 557-563
Rahm, Ann‐Kathrin; Gierten, Jakob; Kisselbach, Jana; Staudacher, Ingo; Staudacher, Kathrin; Schweizer, Patrick A; Becker, Rüdiger; Katus, Hugo A; Thomas, Dierk

PKC‐dependent activation of human K2P18.1 K+ channels

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Wiley, 2012

Published in: British Journal of Pharmacology, 166 (2012) 2, Seite 764-773
Leger, Adrien; Brettell, Ian; Monahan, Jack; Barton, Carl; Wolf, Nadeshda; Kusminski, Natalja; Herder, Cathrin; Aadepu, Narendar; Becker, Clara; Gierten, Jakob; Hammouda, Omar T.; Hasel, Eva; Lischik, Colin; Lust, Katharina; Sokolova, Natalia; Suzuki, Risa; Tavhelidse, Tinatini; Thumberger, Thomas; Tsingos, Erika; Watson, Philip; Welz, Bettina; Naruse, Kiyoshi; Loosli, Felix; Wittbrodt, Joachim; [...]

Genomic variations and epigenomic landscape of the Medaka Inbred Kiyosu-Karlsruhe (MIKK) panel

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Springer Science and Business Media LLC, 2022

Published in: Genome Biology, 23 (2022) 1
Fitzgerald, Tomas; Brettell, Ian; Leger, Adrien; Wolf, Nadeshda; Kusminski, Natalja; Monahan, Jack; Barton, Carl; Herder, Cathrin; Aadepu, Narendar; Gierten, Jakob; Becker, Clara; Hammouda, Omar T.; Hasel, Eva; Lischik, Colin; Lust, Katharina; Sokolova, Natalia; Suzuki, Risa; Tsingos, Erika; Tavhelidse, Tinatini; Thumberger, Thomas; Watson, Philip; Welz, Bettina; Khouja, Nadia; Naruse, Kiyoshi; [...]

The Medaka Inbred Kiyosu-Karlsruhe (MIKK) panel

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Springer Science and Business Media LLC, 2022

Published in: Genome Biology, 23 (2022) 1
Meyer, Hannah V.; Dawes, Timothy J. W.; Serrani, Marta; Bai, Wenjia; Tokarczuk, Paweł; Cai, Jiashen; de Marvao, Antonio; Henry, Albert; Lumbers, R. Thomas; Gierten, Jakob; Thumberger, Thomas; Wittbrodt, Joachim; Ware, James S.; Rueckert, Daniel; Matthews, Paul M.; Prasad, Sanjay K.; Costantino, Maria L.; Cook, Stuart A.; Birney, Ewan; O’Regan, Declan P.

Genetic and functional insights into the fractal structure of the heart

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Springer Science and Business Media LLC, 2020

Published in: Nature, 584 (2020) 7822, Seite 589-594

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