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  1. Loretz, Brigitta [Other]; Lehr, Claus Michael [Other]; Ratnesh, Jain [Other]

    Nanoskalige Carrier aus Stärkederivaten für den gerichteten Transport von antineoplastischen Pharmaka : speziell: Funktionelle Stärkederivate ; Schlussbericht Projekt Nr. 13N9133 "NanoStarch Carriers" ; Projektlaufzeit: 01.02.2007 - 31.07.2010

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    Saarbrücken: Abt. Biopharmazie und Pharmazeutische Techn., Univ. des Saarlandes, 2011

  2. Lehr, Claus-Michael [Author]; Loretz, Brigitta [Author]; Huck, C. Benedikt [Author]; Durairaj, Thiyagarajan [Author] ; Helmholtz-Zentrum für Infektionsforschung

    Antibiotika Nanocarrier zur therapeutischen Inhalation gegen Tuberkulose - ANTI-TB; Teilvorhaben: Optimierung der Wechselwirkungen mit dem Flüssigkeitsfilm der Lunge und Entwicklung einer Pulverformulierung zur Inhalation der Antibiotika-Nanocarrier Systeme : öffentlicher Schlussbericht : Förderung von Diagnostika und neuartigen Therapien zur Behandlung bakterieller Infektionen : Laufzeit: 10/2017-06/2021

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    Saarbrücken: [Helmholtz Institut für Pharmazeutische Forschung Saarland (HIPS)], [2021?]

  3. Jain, Ratnesh [Other]; Dandekar, Prajakta [Other]; Loretz, Brigitta [Other]; Koch, Marcus [Other]; Lehr, Claus-Michael [Other] ; Leibniz-Institut für Neue Materialien

    Dimethylaminoethyl methacrylate copolymer-siRNA nanoparticles for silencing a therapeutically relevant gene in macrophages

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    2015

    Published in: MedChemComm ; 6(2015), 4, Seite 691-701

  4. Dandekar, Prajakta [Other]; Jain, Ratnesh [Other]; Keil, Manuel [Other]; Loretz, Brigitta [Other]; Koch, Marcus [Other]; Wenz, Gerhard [Other]; Lehr, Claus-Michael [Other] ; Leibniz-Institut für Neue Materialien

    Enhanced uptake and siRNA-mediated knockdown of a biologically relevant gene using cyclodextrin polyrotaxane

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    2015

    Published in: Journal of materials chemistry. B, Materials for biology and medicine ; 3(2015), 13, Seite 2590-2598

  5. Andima, Moses [Author]; Boese, Annette [Author]; Paul, Pascal [Author]; Koch, Marcus [Author]; Loretz, Brigitta [Author]; Lehr, Claus-Michael [Author] ; Leibniz-Institut für Neue Materialien, Leibniz-Institut für Neue Materialien

    Targeting intracellular bacteria with dual drug-loaded lactoferrin nanoparticles

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    2024

    Published in: American Chemical Society: ACS infectious diseases ; 19(2024), 5, Seite 1696–1710

  6. Nasr, Sarah S. [Author]; Lee, Sangeun [Author]; Thiyagarajan, Durairaj [Author]; Boese, Annette [Author]; Loretz, Brigitta [Author]; Lehr, Claus-Michael [Author]

    Co-delivery of mRNA and pDNA using thermally stabilized coacervate-based core-shell nanosystems

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    Basel: MDPI, 13 November 2021

    Published in: Pharmaceutics ; 13, 11 (2021), 1924

  7. Ho, Duy-Khiet [Author]; DeRossi, Chiara [Author]; Loretz, Brigitta [Author]; Murgia Esteve, Xabier [Author]; Lehr, Claus-Michael [Author]

    Itaconic acid increases the efficacy of tobramycin against "pseudomonas aeruginosa" biofilms

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    Basel: MDPI, 2020

    Published in: Pharmaceutics ; 12, 8 (2020), 691

  8. Menina, Sara [Author]; Eisenbeis, Janina [Author]; Kamal, Mohamed Ashraf M. [Author]; Koch, Marcus [Author]; Bischoff, Markus [Author]; Gordon, Sarah [Author]; Loretz, Brigitta [Author] ; Lehr, Claus-Michael [Other] Leibniz-Institut für Neue Materialien, Leibniz-Institut für Neue Materialien

    Bioinspired liposomes for oral delivery of colistin to combat intracellular infections by Salmonella enterica

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    2019

    Published in: Advanced healthcare materials ; 8(2019), 17, Artikel-ID 1900564, Seite 1-12

  9. Yasar, Hanzey [Author]; Biehl, Alexander [Author]; De Rossi, Chiara [Author]; Koch, Marcus [Author]; Murgia, Xabi [Author]; Loretz, Brigitta [Author]; Lehr, Claus-Michael [Author] ; Leibniz-Institut für Neue Materialien, Leibniz-Institut für Neue Materialien

    Kinetics of mRNA delivery and protein translation in dendritic cells using lipid-coated PLGA nanoparticles

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    2018

    Published in: Journal of nanobiotechnology ; 16(2018), Artikel-ID 16:72, Seite 1-19

  10. Müller, Rolf [Author]; Stadler, Marc [Author]; Lehr, Claus-Michael [Author]; Herrmann, Jennifer [Author]; Kirsch-Dahmen, Susanne [Author]; Kany, Andreas [Author]; Große, Miriam [Author]; Loretz, Brigitta [Author]; Deschner, Felix [Author] ; Helmholtz-Institut für Pharmazeutische Forschung Saarland

    Naturstoffmedizin: Optimierung von Chlorotonil für die präklinische Evaluierung als potentiellen neuen Wirkstoff gegen Malaria und bakterielle Infektionen mit multiresistenten Erregern (ChloroClinaria) - Strukturoptimierung, Formulierung und Evaluierung der antibakteriellen Wirksamkeit und Wirkweise : Veröffentlichung der Ergebnisse von Forschungsvorhaben im BMBF-Programm : Laufzeit: 01.03.2019-30.11.2022 = Natural product medicine: optimization of chlorotonil for preclinical evaluation as a potential new agent against malaria and bacterial infections with multidrug-resistant pathogens (ChloroClinaria) - structural optimization, formulation and evaluation of antibacterial efficacy and mode of action.

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    Saarbrücken: Helmholtz-Zentrum für Infektionsforschung GmbH (HZI) und Standort Helmholtz-Institut für Pharmazeutische Forschung Saarland (HIPS), 31.05.2023

  11. Kliesch, Lena [Author]; Delandre, Simon [Author]; Gabelmann, Aljoscha [Author]; Koch, Marcus [Author]; Schulze, Kai [Author]; Guzmán, Carlos [Author]; Loretz, Brigitta [Author]; Lehr, Claus-Michael [Author] ; Leibniz-Institut für Neue Materialien, Leibniz-Institut für Neue Materialien

    Lipid–polymer hybrid nanoparticles for mRNA delivery to dendritic cells : impact of lipid composition on performance in different media

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    2022

    Published in: Pharmaceutics ; 14(2022), 12, Artikel-ID 2675, Seite 1-18

  12. Yasar, Hanzey [Author]; Ho, Duy-Khiet [Author]; DeRossi, Chiara [Author]; Herrmann, Jennifer [Author]; Gordon, Sarah [Author]; Loretz, Brigitta [Author]; Lehr, Claus-Michael [Author]

    Starch-chitosan polyplexes : a versatile carrier system for anti-infectives and gene delivery

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    Basel: MDPI, 2018

    Published in: Polymers ; 10, 3 (2018), 252

  13. Heinrich, Eilien [Author]; Hartwig, Olga [Author]; Walt, Christine [Author]; Kardani, Arefeh [Author]; Jahromi, Leila Pourtalebi [Author]; Hoppstädter, Jessica [Author]; Kiemer, Alexandra Kathrin [Author]; Loretz, Brigitta [Author]; Lehr, Claus-Michael [Author]; Fuhrmann, Gregor [Author] ; Leibniz-Institut für Neue Materialien, Leibniz-Institut für Neue Materialien

    Cell-derived vesicles for antibiotic delivery : understanding the challenges of a biogenic carrier system

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    2023

    Published in: Small ; 19(2023), 25, Artikel-ID 2207479, Seite 1-14

  14. Ho, Duy-Khiet [Author]; Christmann, Rebekka [Author]; Murgia Esteve, Xabier [Author]; DeRossi, Chiara [Author]; Frisch, Sarah [Author]; Koch, Marcus [Author]; Schaefer, Ulrich F. [Author]; Loretz, Brigitta [Author]; Desmaele, Didier [Author]; Couvreur, Patrick [Author]; Lehr, Claus-Michael [Author] ; Leibniz-Institut für Neue Materialien, Leibniz-Institut für Neue Materialien

    Synthesis and biopharmaceutical characterization of amphiphilic squalenyl derivative based versatile drug delivery platform

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    2020

    Published in: Frontiers in Chemistry ; 8(2020), Artikel-ID 584242, Seite 1-14

  15. Christmann, Rebekka [Author]; Ho, Duy-Khiet [Author]; Wilzopolski, Jenny [Author]; Lee, Sangeun [Author]; Koch, Marcus [Author]; Loretz, Brigitta [Author]; Vogt, Thomas [Author]; Bäumer, Wolfgang [Author]; Schaefer, Ulrich F. [Author]; Lehr, Claus-Michael [Author] ; Leibniz-Institut für Neue Materialien, Leibniz-Institut für Neue Materialien

    Tofacitinib loaded squalenyl nanoparticles for targeted follicular delivery in inflammatory skin diseases

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    2020

    Published in: Pharmaceutics ; 12(2020), 12, Artikel-ID 1131, Seite 1-17

  16. Thiyagarajan, Durairaj [Author]; Huck, Benedikt [Author]; Nothdurft, Birgit [Author]; Koch, Marcus [Author]; Rudolph, David [Author]; Rutschmann, Mark [Author]; Feldmann, Claus [Author]; Hozsa, Constantin [Author]; Furch, Marcus [Author]; Besecke, Karen F. W. [Author]; Gieseler, Robert K. [Author]; Loretz, Brigitta [Author]; Lehr, Claus-Michael [Author] ; Leibniz-Institut für Neue Materialien, Leibniz-Institut für Neue Materialien

    Spray‑dried lactose‑leucine microparticles for pulmonary delivery of antimycobacterial nanopharmaceuticals

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    2021

    Published in: Drug Delivery and Translational Research ; 11(2021), 4, Seite 1766-1778

  17. Ho, Duy-Khiet [Author]; Murgia, Xabier [Author]; De Rossi, Chiara [Author]; Christmann, Rebekka [Author]; Hüfner de Mello Martins, Antonio Gurdjieff [Author]; Koch, Marcus [Author]; Andreas, Anastasia [Author]; Herrmann, Jennifer [Author]; Müller, Rolf [Author]; Empting, Martin [Author]; Hartmann, Rolf W. [Author]; Desmaele, Didier [Author]; Loretz, Brigitta [Author]; Couvreur, Patrick [Author]; Lehr, Claus-Michael [Author] ; Leibniz-Institut für Neue Materialien, Leibniz-Institut für Neue Materialien

    Squalenyl hydrogen sulfate nanoparticles for simultaneous delivery of tbramycin and an alkylquinolone quorum sensing inhibitor enable the eradication of P. aeruginosa biofilm infections

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    2020

    Published in: Angewandte Chemie. International edition ; 59(2020), 26, Seite 10292-10296

  18. Huck, Benedikt [Author]; Durairaj, Thiyagarajan [Author]; Bali, Aghiad [Author]; Boese, Annette [Author]; Besecke, Karen [Author]; Hozsa, Constantin [Author]; Gieseler, Robert [Author]; Furch, Marcus [Author]; Carvalho‐Wodarz, Cristiane [Author]; Waldow, Franziska [Author]; Schwudke, Dominik [Author]; Metelkina, Olga [Author]; Titz, Alexander [Author]; Huwer, Hanno [Author]; Schwarzkopf, Konrad [Author]; Hoppstädter, Jessica [Author]; Kiemer, Alexandra Kathrin [Author]; Loretz, Brigitta [Author]; Lehr, Claus-Michael [Author] ; Leibniz-Institut für Neue Materialien, Leibniz-Institut für Neue Materialien

    Nano-in-microparticles for aerosol delivery of antibiotic-loaded, fucose-derivatized, and macrophage-targeted liposomes to combat mycobacterial infections: In vitro deposition, pulmonary barrier interactions, and targeted delivery

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    2022

    Published in: Advanced healthcare materials ; 11(2022), 11, Artikel-ID 2102117, Seite 1-16

  19. Schütz, Christian [Author]; Ho, Duy-Khiet [Author]; Hamed, Mostafa Mohamed [Author]; Abdelsamie, Ahmed Saad [Author]; Röhrig, Teresa [Author]; Herr, Christian [Author]; Kany, Andreas Martin [Author]; Rox, Katharina [Author]; Schmelz, Stefan [Author]; Siebenbürger, Lorenz [Author]; Wirth, Marius [Author]; Börger, Carsten [Author]; Yahiaoui, Samir [Author]; Bals, Robert [Author]; Scrima, Andrea [Author]; Blankenfeldt, Wulf [Author]; Horstmann, Justus Constantin [Author]; Christmann, Rebekka [Author]; Murgia Esteve, Xabier [Author]; Koch, Marcus [Author]; Berwanger, Aylin [Author]; Loretz, Brigitta [Author]; Hirsch, Anna Katharina Herta [Author]; Hartmann, Rolf Wolfgang [Author]; [...] ; Leibniz-Institut für Neue Materialien, Leibniz-Institut für Neue Materialien

    A new PqsR inverse agonist potentiates tobramycin efficacy to eradicate Pseudomonas aeruginosa biofilms

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    2021

    Published in: Advanced science ; 8(2021), 12, Artikel-ID 2004369, Seite 1-12