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  1. Duke-Elder, Stewart [Author]; MacFaul, Peter A. [Author]

    Injuries

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    London: Kimpton, 19XX-

    Published in: System of opthalmology ; 14

  2. Duke-Elder, Stewart [Author]; MacFaul, Peter A. [Author]

    The ocular adnexa

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    London: Kimpton, 19XX-

    Published in: System of ophthalmology ; 13

  3. Leach, Andrew G.; Jones, Huw D.; Cosgrove, David A.; Kenny, Peter W.; Ruston, Linette; MacFaul, Philip; Wood, J. Matthew; Colclough, Nicola; Law, Brian

    Matched Molecular Pairs as a Guide in the Optimization of Pharmaceutical Properties; a Study of Aqueous Solubility, Plasma Protein Binding and Oral Exposure

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    American Chemical Society (ACS), 2006

    Published in: Journal of Medicinal Chemistry, 49 (2006) 23, Seite 6672-6682

  4. Scott, James S.; Bailey, Andrew; Davies, Robert D. M.; Degorce, Sébastien L.; MacFaul, Philip A.; Gingell, Helen; Moss, Thomas; Norman, Richard A.; Pink, Jennifer H.; Rabow, Alfred A.; Roberts, Bryan; Smith, Peter D.

    Tetrahydroisoquinoline Phenols: Selective Estrogen Receptor Downregulator Antagonists with Oral Bioavailability in Rat

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    American Chemical Society (ACS), 2016

    Published in: ACS Medicinal Chemistry Letters, 7 (2016) 1, Seite 94-99

  5. De Savi, Chris; Bradbury, Robert H.; Rabow, Alfred A.; Norman, Richard A.; Buttar, David; Currie, Gordon S.; Weir, Hazel; Donald, Craig; Andrews, David; MacFaul, Phil; Ballard, Peter; Curwen, Jon; Wilson, Zena; Richmond, Graham; D'Cruz, Celina; Powell, Steve; Walker, Graeme; Hulse, Michael; Tonge, Michael

    Abstract 3650: Discovery of the clinical candidate AZD9496: a potent and orally bioavailable selective estrogen receptor downregulator and antagonist

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    American Association for Cancer Research (AACR), 2015

    Published in: Cancer Research, 75 (2015) 15_Supplement, Seite 3650-3650

  6. Crawford, James J.; Kenny, Peter W.; Bowyer, Jonathan; Cook, Calum R.; Finlayson, Jonathan E.; Heyes, Christine; Highton, Adrian J.; Hudson, Julian A.; Jestel, Anja; Krapp, Stephan; Martin, Scott; MacFaul, Philip A.; McDermott, Benjamin P.; McGuire, Thomas M.; Morley, Andrew D.; Morris, Jeffrey J.; Page, Ken M.; Ribeiro, Lyn Rosenbrier; Sawney, Helen; Steinbacher, Stefan; Smith, Caroline; Dossetter, Alexander G.

    Pharmacokinetic Benefits of 3,4-Dimethoxy Substitution of a Phenyl Ring and Design of Isosteres Yielding Orally Available Cathepsin K Inhibitors

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    American Chemical Society (ACS), 2012

    Published in: Journal of Medicinal Chemistry, 55 (2012) 20, Seite 8827-8837

  7. De Savi, Chris; Bradbury, Robert H.; Rabow, Alfred A.; Norman, Richard A.; de Almeida, Camila; Andrews, David M.; Ballard, Peter; Buttar, David; Callis, Rowena J.; Currie, Gordon S.; Curwen, Jon O.; Davies, Chris D.; Donald, Craig S.; Feron, Lyman J. L.; Gingell, Helen; Glossop, Steven C.; Hayter, Barry R.; Hussain, Syeed; Karoutchi, Galith; Lamont, Scott G.; MacFaul, Philip; Moss, Thomas A.; Pearson, Stuart E.; Tonge, Michael; [...]

    Optimization of a Novel Binding Motif to (E)-3-(3,5-Difluoro-4-((1R,3R)-2-(2-fluoro-2-methylpropyl)-3-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl)phenyl)acrylic Acid (AZD9496), a Potent and Orally Bioavailable Selective Estrogen Receptor Downregulator and Antagonist

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    American Chemical Society (ACS), 2015

    Published in: Journal of Medicinal Chemistry, 58 (2015) 20, Seite 8128-8140

  8. Weir, Hazel M.; Bradbury, Robert H.; Lawson, Mandy; Rabow, Alfred A.; Buttar, David; Callis, Rowena J.; Curwen, Jon O.; de Almeida, Camila; Ballard, Peter; Hulse, Michael; Donald, Craig S.; Feron, Lyman J.L.; Karoutchi, Galith; MacFaul, Philip; Moss, Thomas; Norman, Richard A.; Pearson, Stuart E.; Tonge, Michael; Davies, Gareth; Walker, Graeme E.; Wilson, Zena; Rowlinson, Rachel; Powell, Steve; Sadler, Claire; [...]

    AZD9496: An Oral Estrogen Receptor Inhibitor That Blocks the Growth of ER-Positive and ESR1-Mutant Breast Tumors in Preclinical Models

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    American Association for Cancer Research (AACR), 2016

    Published in: Cancer Research, 76 (2016) 11, Seite 3307-3318

  9. Dossetter, Alexander G.; Beeley, Howard; Bowyer, Jonathan; Cook, Calum R.; Crawford, James J.; Finlayson, Jonathan E.; Heron, Nicola M.; Heyes, Christine; Highton, Adrian J.; Hudson, Julian A.; Jestel, Anja; Kenny, Peter W.; Krapp, Stephan; Martin, Scott; MacFaul, Philip A.; McGuire, Thomas M.; Gutierrez, Pablo Morentin; Morley, Andrew D.; Morris, Jeffrey J.; Page, Ken M.; Ribeiro, Lyn Rosenbrier; Sawney, Helen; Steinbacher, Stefan; Smith, Caroline;

    (1R,2R)-N-(1-Cyanocyclopropyl)-2-(6-methoxy-1,3,4,5-tetrahydropyrido[4,3-b]indole-2-carbonyl)cyclohexanecarboxamide (AZD4996): A Potent and Highly Selective Cathepsin K Inhibitor for the Treatment of Osteoarthritis

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    American Chemical Society (ACS), 2012

    Published in: Journal of Medicinal Chemistry, 55 (2012) 14, Seite 6363-6374

  10. Sazonovs, Aleksejs; Kennedy, Nicholas A.; Moutsianas, Loukas; Heap, Graham A.; Rice, Daniel L.; Reppell, Mark; Bewshea, Claire M.; Chanchlani, Neil; Walker, Gareth J.; Perry, Mandy H.; McDonald, Timothy J.; Lees, Charlie W.; Cummings, J.R. Fraser; Parkes, Miles; Mansfield, John C.; Irving, Peter M.; Barrett, Jeffrey C.; McGovern, Dermot; Goodhand, James R.; Anderson, Carl A.; Ahmad, Tariq; Patel, Vinod; Mazhar, Zia; Saich, Rebecca; [...]

    HLA-DQA1*05 Carriage Associated With Development of Anti-Drug Antibodies to Infliximab and Adalimumab in Patients With Crohn’s Disease

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    Elsevier BV, 2020

    Published in: Gastroenterology, 158 (2020) 1, Seite 189-199

  11. Cordell, Heather J.; Han, Younghun; Mells, George F.; Li, Yafang; Hirschfield, Gideon M.; Greene, Casey S.; Xie, Gang; Juran, Brian D.; Zhu, Dakai; Qian, David C.; Floyd, James A. B.; Morley, Katherine I.; Prati, Daniele; Lleo, Ana; Cusi, Daniele; Schlicht, Erik M; Lammert, Craig; Atkinson, Elizabeth J; Chan, Landon L; de Andrade, Mariza; Balschun, Tobias; Mason, Andrew L; Myers, Robert P; Zhang, Jinyi; [...]

    International genome-wide meta-analysis identifies new primary biliary cirrhosis risk loci and targetable pathogenic pathways

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    Springer Science and Business Media LLC, 2015

    Published in: Nature Communications, 6 (2015) 1

  12. Asselta, Rosanna; Paraboschi, Elvezia M.; Gerussi, Alessio; Cordell, Heather J.; Mells, George F.; Sandford, Richard N.; Jones, David E.; Nakamura, Minoru; Ueno, Kazuko; Hitomi, Yuki; Kawashima, Minae; Nishida, Nao; Tokunaga, Katsushi; Nagasaki, Masao; Tanaka, Atsushi; Tang, Ruqi; Li, Zhiqiang; Shi, Yongyong; Liu, Xiangdong; Xiong, Ma; Hirschfield, Gideon; Siminovitch, Katherine A.; Carbone, Marco; Cardamone, Giulia; [...]

    X Chromosome Contribution to the Genetic Architecture of Primary Biliary Cholangitis

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    Elsevier BV, 2021

    Published in: Gastroenterology, 160 (2021) 7, Seite 2483-2495.e26

  13. Lin, Simeng; Kennedy, Nicholas A.; Saifuddin, Aamir; Sandoval, Diana Muñoz; Reynolds, Catherine J.; Seoane, Rocio Castro; Kottoor, Sherine H.; Pieper, Franziska P.; Lin, Kai-Min; Butler, David K.; Chanchlani, Neil; Nice, Rachel; Chee, Desmond; Bewshea, Claire; Janjua, Malik; McDonald, Timothy J.; Sebastian, Shaji; Alexander, James L.; Constable, Laura; Lee, James C.; Murray, Charles D.; Hart, Ailsa L.; Irving, Peter M.; Jones, Gareth-Rhys; [...]

    Antibody decay, T cell immunity and breakthrough infections following two SARS-CoV-2 vaccine doses in inflammatory bowel disease patients treated with infliximab and vedolizumab

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    Springer Science and Business Media LLC, 2022

    Published in: Nature Communications, 13 (2022) 1