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  2. King, Kristina [Author]; Hauser, Alexander-Thomas [Author]; Melesina, Jelena [Author]; Sippl, Wolfgang [Author]; Jung, Manfred [Author]

    Carbamates as potential prodrugs and a new warhead for HDAC inhibition

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    Basel: MDPI, 2018

    Published in: Molecules ; 23, 2 (2018), article no. 321

  3. Bülbül, Emre F. [Author]; Robaa, Dina [Author]; Sun, Ping [Author]; Mahmoudi, Fereshteh [Author]; Melesina, Jelena [Author]; Zessin, Matthes [Author]; Schutkowski, Mike [Author]; Sippl, Wolfgang [Author]

    Application of ligand- and structure-based prediction models for the design of alkylhydrazide-based HDAC3 inhibitors as novel anti-cancer compounds

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    2023

    Published in: Pharmaceuticals ; 16(2023), 7, Artikel-ID 968

  4. Zähringer, Sarah [Author]; Rumpf, Tobias [Author]; Melesina, Jelena [Author]; Lang, Alexander E. [Author]; Aktories, Klaus [Author]; Sippl, Wolfgang [Author]; Jung, Manfred [Author]; Wagner, Gerd K. [Author]

    Defined stereoisomers of 2″-amino NAD+ and their activity against human sirtuins and a bacterial (ADP-ribosyl) transferase

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    2022

    Published in: Bioorganic & medicinal chemistry ; 68(2022), Artikel-ID 116875

  5. Zähringer, Sarah [Author]; Rumpf, Tobias [Author]; Melesina, Jelena [Author]; Lang, Alexander E. [Author]; Aktories, Klaus [Author]; Sippl, Wolfgang [Author]; Jung, Manfred [Author]; Wagner, Gerd K [Author]

    Defined stereoisomers of 2″-amino NAD+ and their activity against human sirtuins and a bacterial (ADP-ribosyl) transferase

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    Amsterdam [u.a.]: Elsevier BV, 2022

    Published in: Bioorganic & medicinal chemistry ; 68 (2022), 116875

  6. Bülbül, Emre F. [Author]; Melesina, Jelena [Author]; Ibrahim, Hany S. [Author]; Abdelsalam, Mohamed [Author]; Vecchio, Anita [Author]; Robaa, Dina [Author]; Zessin, Matthes [Author]; Schutkowski, Mike [Author]; Sippl, Wolfgang [Author]

    Docking, binding free energy calculations and in vitro characterization of pyrazine linked 2-aminobenzamides as novel class I histone deacetylase (HDAC) inhibitors

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    2022

    Published in: Molecules ; 27(2022), 8, Artikel-ID 2526

  7. Zessin, Matthes [Author]; Meleshin, Marat [Author]; Simic, Zeljko [Author]; Kalbas, Diana [Author]; Arbach, Miriam [Author]; Gebhardt, Philip [Author]; Melesina, Jelena [Author]; Liebscher, Sandra [Author]; Bordusa, Frank [Author]; Sippl, Wolfgang [Author]; Barinka, Cyril [Author]; Schutkowski, Mike [Author]

    Continuous Sirtuin/HDAC (histone deacetylase) activity assay using thioamides as PET (Photoinduced Electron Transfer)-based fluorescence quencher

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    2021

    Published in: Bioorganic chemistry ; 117(2021), Artikel-ID 105425

  8. Kalinin, Dmitrii V. [Author]; Jana, Sunit Kumar [Author]; Pfafenrot, Maxim [Author]; Chakrabarti, Alokta [Author]; Melesina, Jelena [Author]; Shaik, Tajith B. [Author]; Lancelot, Julien [Author]; Pierce, Raymond J. [Author]; Sippl, Wolfgang [Author]; Romier, Christophe [Author]; Jung, Manfred [Author]; Holl, Ralph [Author]

    Structure‐based design, synthesis, and biological evaluation of triazole‐based smHDAC8 inhibitors

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    2020

    Published in: ChemMedChem ; 15(2020), 7, Seite 571-584

  9. Kalinin, Dmitrii V. [Author]; Jana, Sunit Kumar [Author]; Pfafenrot, Maxim [Author]; Chakrabarti, Alokta [Author]; Melesina, Jelena [Author]; Shaik, Tajith B. [Author]; Lancelot, Julien [Author]; Pierce, Raymond J. [Author]; Sippl, Wolfgang [Author]; Romier, Christophe [Author]; Jung, Manfred [Author]; Holl, Ralph [Author]

    Structure‐based design, synthesis, and biological evaluation of triazole‐based smHDAC8 inhibitors

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    Weinheim: Wiley-VCH, 2020

    Published in: ChemMedChem ; 15, 7 (2020), 571-584

  10. Marek, Martin [Author]; Shaik, Tajith B. [Author]; Heimburg, Tino [Author]; Chakrabarti, Alokta [Author]; Lancelot, Julien [Author]; Ramos-Morales, Elizabeth [Author]; Da Veiga, Cyrielle [Author]; Kalinin, Dmitrii [Author]; Melesina, Jelena [Author]; Robaa, Dina [Author]; Schmidtkunz, Karin [Author]; Suzuki, Takayoshi [Author]; Holl, Ralph [Author]; Ennifar, Eric [Author]; Pierce, Raymond J. [Author]; Jung, Manfred [Author]; Sippl, Wolfgang [Author]; Romier, Christophe [Author]

    Characterization of histone deacetylase 8 (HDAC8) selective inhibition reveals specific active site structural and functional determinants

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    October 22, 2018

    Published in: Journal of medicinal chemistry ; 61(2018), 22, Seite 10000-10016

  11. Simoben, Conrad V. [Author]; Robaa, Dina [Author]; Chakrabarti, Alokta [Author]; Schmidtkunz, Karin [Author]; Marek, Martin [Author]; Lancelot, Julien [Author]; Kannan, Srinivasaraghavan [Author]; Melesina, Jelena [Author]; Shaik, Tajith B. [Author]; Pierce, Raymond J. [Author]; Romier, Christophe [Author]; Jung, Manfred [Author]; Sippl, Wolfgang [Author]

    A novel class of Schistosoma mansoni histone deacetylase 8 (HDAC8) inhibitors identified by structure-based virtual screening and in vitro testing

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    Basel: MDPI, 2018

    Published in: Molecules ; 23, 3 (2018), article no. 566

  12. Stolfa, Diana A. [Author]; Marek, Martin [Author]; Lancelot, Julien [Author]; Hauser, Alexander-Thomas [Author]; Walter, Alexandra [Author]; Leproult, Emeline [Author]; Melesina, Jelena [Author]; Rumpf, Tobias [Author]; Wurtz, Jean-Marie [Author]; Cavarelli, Jean [Author]; Sippl, Wolfgang [Author]; Pierce, Raymond J. [Author]; Romier, Christophe [Author]; Jung, Manfred [Author]

    Molecular basis for the antiparasitic activity of a mercaptoacetamide derivative that inhibits histone deacetylase 8 (HDAC8) from the human pathogen schistosoma mansoni

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    Amsterdam [u.a.]: Elsevier, 2014

    Published in: Journal of molecular biology ; Volume 426, Issue 20 (2014), pages 3442-3453

  16. Kahlert, Viktoria; Prell, Erik; Ohlenschläger, Oliver; Melesina, Jelena; Schumann, Michael; Lücke, Christian; Fischer, Gunter; Malešević, Miroslav

    Synthesis and biochemical evaluation of two novel N-hydroxyalkylated cyclosporin A analogs

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    Royal Society of Chemistry (RSC), 2018

    Published in: Organic & Biomolecular Chemistry, 16 (2018) 23, Seite 4338-4349

  17. Senger, Johanna; Melesina, Jelena; Marek, Martin; Romier, Christophe; Oehme, Ina; Witt, Olaf; Sippl, Wolfgang; Jung, Manfred

    Synthesis and Biological Investigation of Oxazole Hydroxamates as Highly Selective Histone Deacetylase 6 (HDAC6) Inhibitors

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    American Chemical Society (ACS), 2016

    Published in: Journal of Medicinal Chemistry, 59 (2016) 4, Seite 1545-1555

  18. Wang, Lei; Kofler, Marina; Brosch, Gerald; Melesina, Jelena; Sippl, Wolfgang; Martinez, Elisabeth D.; Easmon, Johnny

    2-Benzazolyl-4-Piperazin-1-Ylsulfonylbenzenecarbohydroxamic Acids as Novel Selective Histone Deacetylase-6 Inhibitors with Antiproliferative Activity

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    Public Library of Science (PLoS), 2015

    Published in: PLOS ONE, 10 (2015) 12, Seite e0134556

  20. Bülbül, Emre F.; Melesina, Jelena; Ibrahim, Hany S.; Abdelsalam, Mohamed; Vecchio, Anita; Robaa, Dina; Zessin, Matthes; Schutkowski, Mike; Sippl, Wolfgang

    Docking, Binding Free Energy Calculations and In Vitro Characterization of Pyrazine Linked 2-Aminobenzamides as Novel Class I Histone Deacetylase (HDAC) Inhibitors

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    MDPI AG, 2022

    Published in: Molecules, 27 (2022) 8, Seite 2526