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Kloos, Arnold [Author]; Mintzas, Konstantinos [Author]; Winckler, Lina [Author]; Gabdoulline, Razif [Author]; Alwie, Yasmine [Author]; Jyotsana, Nidhi [Author]; Kattre, Nadine [Author]; Schottmann, Renate [Author]; Scherr, Michaela [Author]; Gupta, Charu [Author]; Adams, Felix F [Author]; Schwarzer, Adrian [Author]; Heckl, Dirk [Author]; Schambach, Axel [Author]; Imren, Suzan [Author]; Humphries, R Keith [Author]; Ganser, Arnold [Author]; Thol, Felicitas [Author]; Heuser, Michael [Author]

Effective drug treatment identified by in vivo screening in a transplantable patient-derived xenograft model of chronic myelomonocytic leukemia

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2020

Published in: Leukemia ; 34(2020), 11, Seite 2951-2963
CHRISTIANS, UWE; SCHMIDT, GUDRUN; BADER, AUGUSTINUS; LAMPEN, ALFONS; SCHOTTMANN, RENATE; LINCK, ANNETTE; SEWING, KARL‐FRIEDRICH

Identification of drugs inhibiting the in vitro metabolism of tacrolimus by human liver microsomes

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Wiley, 1996

Published in: British Journal of Clinical Pharmacology, 41 (1996) 3, Seite 187-190
Christians, Uwe; Radeke, Heinfried H.; Kownatzki, Reinhard; Schiebel, H.M.; Schottmann, Renate; Sewing, Karl-Fr.

Isolation of an immunosuppressive metabolite of FK506 generated by human microsome preparations

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Elsevier BV, 1991

Published in: Clinical Biochemistry, 24 (1991) 3, Seite 271-275
Mintzas, Konstantinos; Kloos, Arnold; Gabdoulline, Razif; Schottmann, Renate; Danisch, Simon; Stripecke, Renata; Ganser, Arnold; Thol, Felicitas; Heuser, Michael

Functional Screening for Pathways Regulating Chemoresistance and Sensitivity in Leukemia Stem Cells

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American Society of Hematology, 2018

Published in: Blood, 132 (2018) Supplement 1, Seite 3933-3933
Christians, Uwe; Kohlhaw, Kay; Sürig, Thomas; Bader, Augustinus; Schottmann, Renate; Linck, Annette; Ringe, Burckhardt; Sewing, Karl-Friedrich

Parallel Blood Concentrations of Second-Generation Cyclosporine Metabolites and Bilirubin in Liver Graft Recipients

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Ovid Technologies (Wolters Kluwer Health), 1995

Published in: Therapeutic Drug Monitoring, 17 (1995) 5, Seite 487-498
Chaturvedi, Anuhar; Gupta, Charu; Kaulfuss, Stefan; Othman, Basem; Görlich, Kerstin; Schottmann, Renate; Panknin, Olaf; Wagner, Markus; Ganser, Arnold; Jeffers, Michael; Haegebarth, Andrea; Heuser, Michael

Efficacy of Chemotherapy, Phd-Inhibitor Molidustat or BRD4 Inhibitor JQ1 in Combination with Targeted Inhibition of Mutated IDH1 in Human AML In Vivo

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American Society of Hematology, 2019

Published in: Blood, 134 (2019) Supplement_1, Seite 3933-3933
Mohanty, Sagarajit; Jyotsana, Nidhi; Sharma, Amit; Othman, Basem; Kloos, Arnold; Mandhania, Madhvi; Schottmann, Renate; Ramsay, Euan; Vornlocher, Hans- Peter; Ganser, Arnold; Thol, Felicitas; Heuser, Michael

Targeted Inhibition of the NUP98-NSD1 Fusion Oncogene in AML

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American Society of Hematology, 2019

Published in: Blood, 134 (2019) Supplement_1, Seite 2545-2545
Chaturvedi, Anuhar; Araujo Cruz, Michelle Maria; Goparaju, Ramya; Gabdoulline, Razif; Schottmann, Renate; Görlich, Kerstin; Kloos, Arnold; Thol, Felicitas; Geffers, Robert; Mougiakakos, Dimitrios; Carmeliet, Peter; Ganser, Arnold; Heuser, Michael

Prolyl Hydroxylase 3 (Phd3) Is a Therapeutic Target in Isocitrate Dehydrogenase 1 (IDH1) Mutated Acute Myeloid Leukemia

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American Society of Hematology, 2018

Published in: Blood, 132 (2018) Supplement 1, Seite 759-759
Kloos, Arnold; Thol, Felicitas; Klesse, Sabrina; Liebich, Alessandro; Trummer, Arne; Schottmann, Renate; Jiménez, Rubén Trespando; Göhring, Gudrun; Schlegelberger, Brigitte; Ganser, Arnold; Heuser, Michael

Patient Derived Xenotransplantation Model of Atypical Chronic Myeloid Leukemia (aCML)

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American Society of Hematology, 2015

Published in: Blood, 126 (2015) 23, Seite 2836-2836
Kloos, Arnold; Mintzas, Konstantinos; Winckler, Lina; Gabdoulline, Razif; Alwie, Yasmine; Jyotsana, Nidhi; Kattre, Nadine; Schottmann, Renate; Scherr, Michaela; Gupta, Charu; Adams, Felix F.; Schwarzer, Adrian; Heckl, Dirk; Schambach, Axel; Imren, Suzan; Humphries, R. Keith; Ganser, Arnold; Thol, Felicitas; Heuser, Michael

Correction: Effective drug treatment identified by in vivo screening in a transplantable patient-derived xenograft model of chronic myelomonocytic leukemia

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Springer Science and Business Media LLC, 2021

Published in: Leukemia, 35 (2021) 12, Seite 3629-3629
Kloos, Arnold; Mintzas, Konstantinos; Winckler, Lina; Gabdoulline, Razif; Alwie, Yasmine; Jyotsana, Nidhi; Kattre, Nadine; Schottmann, Renate; Scherr, Michaela; Gupta, Charu; Adams, Felix F.; Schwarzer, Adrian; Heckl, Dirk; Schambach, Axel; Imren, Suzan; Humphries, R. Keith; Ganser, Arnold; Thol, Felicitas; Heuser, Michael

Effective drug treatment identified by in vivo screening in a transplantable patient-derived xenograft model of chronic myelomonocytic leukemia

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Springer Science and Business Media LLC, 2020

Published in: Leukemia, 34 (2020) 11, Seite 2951-2963
Chaturvedi, Anuhar; Goparaju, Ramya; Gupta, Charu; Weder, Julia; Klünemann, Thomas; Araujo Cruz, Michelle Maria; Kloos, Arnold; Goerlich, Kerstin; Schottmann, Renate; Othman, Basem; Struys, Eduard A.; Bähre, Heike; Grote-Koska, Denis; Brand, Korbinian; Ganser, Arnold; Preller, Matthias; Heuser, Michael

In vivo efficacy of mutant IDH1 inhibitor HMS-101 and structural resolution of distinct binding site

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Springer Science and Business Media LLC, 2020

Published in: Leukemia, 34 (2020) 2, Seite 416-426
Anuhar Chaturvedi; Charu Gupta; Razif Gabdoulline; Nora M. Borchert; Ramya Goparaju; Stefan Kaulfuss; Kerstin Görlich; Renate Schottmann; Basem Othman; Julia Welzenbach; Olaf Panknin; Markus Wagner; Robert Geffers; Arnold Ganser; Felicitas Thol; Michael Jeffers; Andrea Haegebarth; Michael Heuser

Synergistic activity of IDH1 inhibitor BAY1436032 with azacitidine in IDH1 mutant acute myeloid leukemia

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Ferrata Storti Foundation (Haematologica), 2020

Published in: Haematologica, 106 (2020) 2, Seite 565-573
Mohanty, Sagarajit; Jyotsana, Nidhi; Sharma, Amit; Kloos, Arnold; Gabdoulline, Razif; Othman, Basem; Lai, Courteney K.; Schottmann, Renate; Mandhania, Madhvi; Schmoellerl, Johannes; Grebien, Florian; Ramsay, Euan; Thomas, Anitha; Vornlocher, Hans-Peter; Ganser, Arnold; Thol, Felicitas; Heuser, Michael

Targeted Inhibition of the NUP98-NSD1 Fusion Oncogene in Acute Myeloid Leukemia

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MDPI AG, 2020

Published in: Cancers, 12 (2020) 10, Seite 2766
Gupta, Charu; Araujo Cruz, Michelle Maria; Jyotsana, Nidhi; Sharma, Amit; Goparaju, Ramya; Görlich, Kerstin; Schottmann, Renate; Struys, Eduard; Jansen, Erwin E; Thol, Felicitas; Ganser, Arnold; Heuser, Michael; Chaturvedi, Anuhar

Signaling Pathways of Mutant IDH1 Independent of R-2-Hydroxyglutarate

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American Society of Hematology, 2018

Published in: Blood, 132 (2018) Supplement 1, Seite 2617-2617
Chaturvedi, Anuhar; Araujo Cruz, Michelle Maria; Jyotsana, Nidhi; Sharma, Amit; Goparaju, Ramya; Sharma, Vishwas; Schwarzer, Adrian; Goerlich, Kerstin; Schottmann, Renate; Struys, Eduard A.; Jansen, Erwin E.; Geffers, Robert; Goehring, Gudrun; Thol, Felicitas; Ganser, Arnold; Heuser, Michael

The Metabolite R-2-Hydroxyglutarate (R2HG) Collaborates with HoxA9 to Induce Monocytic Leukemia

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American Society of Hematology, 2014

Published in: Blood, 124 (2014) 21, Seite 366-366
Chaturvedi, Anuhar; Araujo Cruz, Michelle Maria; Goparaju, Ramya; Jyotsana, Nidhi; Baehre, Heike; Goerlich, Kerstin; Schottmann, Renate; Preller, Matthias; Struys, Eduard A.; Kloos, Arnold; Kaever, Volkhard; Ganser, Arnold; Thol, Felicitas; Heuser, Michael

A Novel Inhibitor of Mutant IDH1 Induces Differentiation in Vivo and Prolongs Survival in a Mouse Model of Leukemia

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American Society of Hematology, 2014

Published in: Blood, 124 (2014) 21, Seite 3598-3598

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