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Tam, Heng Keat [Author]

Structural characterization of Landomycin O- and C-Glycosyltransferases

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2013
Tam, Heng Keat [Author] ; Einsle, Oliver [Degree supervisor]

Structural Characterization of Landomycin O- and C-Glycosyltransferases

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Freiburg: Universität, 2015
Oswald, Christine; Tam, Heng-Keat; Pos, Klaas M.

Transport of lipophilic carboxylates is mediated by transmembrane helix 2 in multidrug transporter AcrB

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Springer Science and Business Media LLC, 2016

Published in: Nature Communications, 7 (2016) 1
Tam, Heng-Keat; Foong, Wuen Ee; Oswald, Christine; Herrmann, Andrea; Zeng, Hui; Pos, Klaas M.

Allosteric drug transport mechanism of multidrug transporter AcrB

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Springer Science and Business Media LLC, 2021

Published in: Nature Communications, 12 (2021) 1
Sumyk, Manuela; Himpich, Stephanie; Foong, Wuen Ee; Herrmann, Andrea; Pos, Klaas M.; Tam, Heng-Keat

Binding of Tetracyclines to Acinetobacter baumannii TetR Involves Two Arginines as Specificity Determinants

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Frontiers Media SA, 2021

Published in: Frontiers in Microbiology, 12 (2021)
Foong, Wuen Ee; Wilhelm, Jochen; Tam, Heng-Keat; Pos, Klaas M

Tigecycline efflux in Acinetobacter baumannii is mediated by TetA in synergy with RND-type efflux transporters

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Oxford University Press (OUP), 2020

Published in: Journal of Antimicrobial Chemotherapy, 75 (2020) 5, Seite 1135-1139
Foong, Wuen Ee; Tam, Heng-Keat; Crames, Jan J; Averhoff, Beate; Pos, Klaas M

The chloramphenicol/H+ antiporter CraA of Acinetobacter baumannii AYE reveals a broad substrate specificity

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Oxford University Press (OUP), 2019

Published in: Journal of Antimicrobial Chemotherapy, 74 (2019) 5, Seite 1192-1201
Tam, Heng Keat; Wong, Clemente Michael Vui Ling; Yong, Sheau Ting; Blamey, Jenny; González, Marcelo

Multiple-antibiotic-resistant bacteria from the maritime Antarctic

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Springer Science and Business Media LLC, 2015

Published in: Polar Biology, 38 (2015) 8, Seite 1129-1141
Speck, Janina; Hecky, Jochen; Tam, Heng-Keat; Arndt, Katja M.; Einsle, Oliver; Müller, Kristian M.

Exploring the Molecular Linkage of Protein Stability Traits for Enzyme Optimization by Iterative Truncation and Evolution

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American Chemical Society (ACS), 2012

Published in: Biochemistry, 51 (2012) 24, Seite 4850-4867
Tam, Heng-Keat; König, Patricia; Himpich, Stephanie; Ngu, Ngoc Dinh; Abele, Rupert; Müller, Volker; Pos, Klaas M.

Unidirectional mannitol synthesis ofAcinetobacter baumanniiMtlD is facilitated by the helix–loop–helix-mediated dimer formation

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Proceedings of the National Academy of Sciences, 2022

Published in: Proceedings of the National Academy of Sciences, 119 (2022) 14
Tam, Heng Keat; Härle, Johannes; Gerhardt, Stefan; Rohr, Jürgen; Wang, Guojun; Thorson, Jon S.; Bigot, Aurélien; Lutterbeck, Monika; Seiche, Wolfgang; Breit, Bernhard; Bechthold, Andreas; Einsle, Oliver

Structural Characterization of O‐ and C‐Glycosylating Variants of the Landomycin Glycosyltransferase LanGT2

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Wiley, 2015

Published in: Angewandte Chemie International Edition, 54 (2015) 9, Seite 2811-2815
Tam, Heng Keat; Härle, Johannes; Gerhardt, Stefan; Rohr, Jürgen; Wang, Guojun; Thorson, Jon S.; Bigot, Aurélien; Lutterbeck, Monika; Seiche, Wolfgang; Breit, Bernhard; Bechthold, Andreas; Einsle, Oliver

Strukturelle Charakterisierung von O‐ und C‐glycosylierenden Varianten der Landomycin‐Glycosyltransferase LanGT2

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Wiley, 2015

Published in: Angewandte Chemie, 127 (2015) 9, Seite 2853-2857
Plé, Coline; Tam, Heng-Keat; Vieira Da Cruz, Anais; Compagne, Nina; Jiménez-Castellanos, Juan-Carlos; Müller, Reinke T.; Pradel, Elizabeth; Foong, Wuen Ee; Malloci, Giuliano; Ballée, Alexia; Kirchner, Moritz A.; Moshfegh, Parisa; Herledan, Adrien; Herrmann, Andrea; Deprez, Benoit; Willand, Nicolas; Vargiu, Attilio Vittorio; Pos, Klaas M.; Flipo, Marion; Hartkoorn, Ruben C.

Pyridylpiperazine-based allosteric inhibitors of RND-type multidrug efflux pumps

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Springer Science and Business Media LLC, 2022

Published in: Nature Communications, 13 (2022) 1
Wallach, Izhar; Bernard, Denzil; Nguyen, Kong; Ho, Gregory; Morrison, Adrian; Stecula, Adrian; Rosnik, Andreana; O’Sullivan, Ann Marie; Davtyan, Aram; Samudio, Ben; Thomas, Bill; Worley, Brad; Butler, Brittany; Laggner, Christian; Thayer, Desiree; Moharreri, Ehsan; Friedland, Greg; Truong, Ha; van den Bedem, Henry; Ng, Ho Leung; Stafford, Kate; Sarangapani, Krishna; Giesler, Kyle; Ngo, Lien; [...]

AI is a viable alternative to high throughput screening: a 318-target study

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Springer Science and Business Media LLC, 2024

Published in: Scientific Reports, 14 (2024) 1

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