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Toulany, Mahmoud [Author]

Mechanism and role of EGFR tyrosine kinase inhibition in radiation response of human tumor and normal cells

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Toulany, Mahmoud

Targeting K-Ras-mediated DNA damage response in radiation oncology: Current status, challenges and future perspectives

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Elsevier BV, 2023

Published in: Clinical and Translational Radiation Oncology, 38 (2023), Seite 6-14
Toulany, Mahmoud

Targeting DNA Double-Strand Break Repair Pathways to Improve Radiotherapy Response

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MDPI AG, 2019

Published in: Genes, 10 (2019) 1, Seite 25
Toulany, Mahmoud; Lasham, Annette

Close Links between Cold Shock Proteins and Cancer

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MDPI AG, 2023

Published in: Cancers, 15 (2023) 9, Seite 2421
Toulany, Mahmoud; Rodemann, H. Peter

Abstract A48: Crosstalk between ERK2 and Akt1 in tumor cells with constitutive K-RAS activity leads to the limited response to PI3K inhibition

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American Association for Cancer Research (AACR), 2015

Published in: Molecular Cancer Therapeutics, 14 (2015) 7_Supplement, Seite A48-A48
Khozooei, Shayan; Veerappan, Soundaram; Toulany, Mahmoud

Abstract 567: Fisetin sensitizes triple negative breast cancer cells to radiation

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American Association for Cancer Research (AACR), 2024

Published in: Cancer Research, 84 (2024) 6_Supplement, Seite 567-567
Khozooei, Shayan; Veerappan, Soundaram; Toulany, Mahmoud

YB-1 activating cascades as potential targets in KRAS-mutated tumors

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Springer Science and Business Media LLC, 2023

Published in: Strahlentherapie und Onkologie, 199 (2023) 12, Seite 1110-1127
Toulany, Mahmoud; Saki, Mohammad; Rodemann, H. Peter

Abstract A121: Constitutive K-Ras activity independent of K-RAS mutational status leads to resistance to anti-EGFR molecular targeting approaches and MEK-dependent reactivation of Akt following PI3K inhibition

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American Association for Cancer Research (AACR), 2015

Published in: Molecular Cancer Therapeutics, 14 (2015) 12_Supplement_2, Seite A121-A121
Saki, Mohammad; Toulany, Mahmoud; Rodemann, H. Peter

Acquired resistance to cetuximab is associated with the overexpression of Ras family members and the loss of radiosensitization in head and neck cancer cells

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Elsevier BV, 2013

Published in: Radiotherapy and Oncology, 108 (2013) 3, Seite 473-478
Rodemann, H. Peter; Dittmann, Klaus; Toulany, Mahmoud

Radiation-induced EGFR-signaling and control of DNA-damage repair

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Informa UK Limited, 2007

Published in: International Journal of Radiation Biology, 83 (2007) 11-12, Seite 781-791
Toulany, Mahmoud; Baumann, Michael; Rodemann, H. Peter

Stimulated PI3K-AKT Signaling Mediated through Ligand or Radiation-Induced EGFR Depends Indirectly, but not Directly, on Constitutive K-Ras Activity

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American Association for Cancer Research (AACR), 2007

Published in: Molecular Cancer Research, 5 (2007) 8, Seite 863-872
Dehghan Harati, Mozhgan; Rodemann, H. Peter; Toulany, Mahmoud

Nanog Signaling Mediates Radioresistance in ALDH-Positive Breast Cancer Cells

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MDPI AG, 2019

Published in: International Journal of Molecular Sciences, 20 (2019) 5, Seite 1151
Toulany, Mahmoud; Ilda, Mari; Wheeler, Deric L.; Rodemann, H. Peter

Abstract B44: Dual targeting of PI3K and MEK impairs DNA double-strand break repair as a relevant mechanism for radioresistance of K-RAS mutated non-small cell lung cancer

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American Association for Cancer Research (AACR), 2017

Published in: Molecular Cancer Research, 15 (2017) 4_Supplement, Seite B44-B44
Hauth, Franziska; Toulany, Mahmoud; Zips, Daniel; Menegakis, Apostolos

Cell-line dependent effects of hypoxia prior to irradiation in squamous cell carcinoma lines

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Elsevier BV, 2017

Published in: Clinical and Translational Radiation Oncology, 5 (2017), Seite 12-19
Toulany, Mahmoud; Kehlbach, Rainer; Rodemann, H. Peter; Mozdarani, Hossein

Radiocontrast media affect radiation-induced DNA damage repair in vitro and in vivo by affecting Akt signalling

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Elsevier BV, 2010

Published in: Radiotherapy and Oncology, 94 (2010) 1, Seite 110-116
Florczak, Urszula; Toulany, Mahmoud; Kehlbach, Rainer; Peter Rodemann, H.

2-Methoxyestradiol-induced radiosensitization is independent of SOD but depends on inhibition of Akt and DNA-PKcs activities

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Elsevier BV, 2009

Published in: Radiotherapy and Oncology, 92 (2009) 3, Seite 334-338
Toulany, Mahmoud; Dittmann, Klaus; Baumann, Michael; Rodemann, H. Peter

Radiosensitization of Ras-mutated human tumor cells in vitro by the specific EGF receptor antagonist BIBX1382BS

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Elsevier BV, 2005

Published in: Radiotherapy and Oncology, 74 (2005) 2, Seite 117-129
Mueck, Katharina; Rebholz, Simone; Harati, Mozhgan Dehghan; Rodemann, H. Peter; Toulany, Mahmoud

Akt1 Stimulates Homologous Recombination Repair of DNA Double-Strand Breaks in a Rad51-Dependent Manner

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MDPI AG, 2017

Published in: International Journal of Molecular Sciences, 18 (2017) 11, Seite 2473
Seiwert, Nina; Neitzel, Carina; Stroh, Svenja; Frisan, Teresa; Audebert, Marc; Toulany, Mahmoud; Kaina, Bernd; Fahrer, Jörg

AKT2 suppresses pro-survival autophagy triggered by DNA double-strand breaks in colorectal cancer cells

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Springer Science and Business Media LLC, 2017

Published in: Cell Death & Disease, 8 (2017) 8, Seite e3019-e3019
Holler, Marina; Grottke, Astrid; Mueck, Katharina; Manes, Julia; Jücker, Manfred; Rodemann, H. Peter; Toulany, Mahmoud

Dual Targeting of Akt and mTORC1 Impairs Repair of DNA Double-Strand Breaks and Increases Radiation Sensitivity of Human Tumor Cells

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Public Library of Science (PLoS), 2016

Published in: PLOS ONE, 11 (2016) 5, Seite e0154745

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