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Khosravi, Bahram [Author]; LaClair, Kathrine D. [Author]; Riemenschneider, Henrick [Author]; Zhou, Qihui [Author]; Frottin, Frédéric [Author]; Mareljic, Nikola [Author]; Czuppa, Mareike [Author]; Farny, Daniel [Author]; Hartmann, Hannelore [Author]; Michaelsen, Meike [Author]; Arzberger, Thomas [Author]; Hartl, F. Ulrich [Author]; Hipp, Mark S. [Author]; Edbauer, Dieter [Author]

Cell-to-cell transmission of C9orf72 poly-(Gly-Ala) triggers key features of ALS/FTD

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2020

Published in: European Molecular Biology Organization: The EMBO journal ; 39(2020), 8, Artikel-ID e102811, Seite 1-19
Hartmann, Hannelore; Hornburg, Daniel; Czuppa, Mareike; Bader, Jakob; Michaelsen, Meike; Farny, Daniel; Arzberger, Thomas; Mann, Matthias; Meissner, Felix; Edbauer, Dieter

Proteomics and C9orf72 neuropathology identify ribosomes as poly-GR/PR interactors driving toxicity

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Life Science Alliance, LLC, 2018

Published in: Life Science Alliance
Khosravi, Bahram; Hartmann, Hannelore; May, Stephanie; Möhl, Christoph; Ederle, Helena; Michaelsen, Meike; Schludi, Martin H.; Dormann, Dorothee; Edbauer, Dieter

Cytoplasmic poly-GA aggregates impair nuclear import of TDP-43 in C9orf72 ALS/FTLD

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Oxford University Press (OUP), 2016

Published in: Human Molecular Genetics
Zhou, Qihui; Mareljic, Nikola; Michaelsen, Meike; Parhizkar, Samira; Heindl, Steffanie; Nuscher, Brigitte; Farny, Daniel; Czuppa, Mareike; Schludi, Carina; Graf, Alexander; Krebs, Stefan; Blum, Helmut; Feederle, Regina; Roth, Stefan; Haass, Christian; Arzberger, Thomas; Liesz, Arthur; Edbauer, Dieter

Active poly‐GA vaccination prevents microglia activation and motor deficits in a C9orf72 mouse model

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Springer Science and Business Media LLC, 2020

Published in: EMBO Molecular Medicine
Khosravi, Bahram; LaClair, Kathrine D; Riemenschneider, Henrick; Zhou, Qihui; Frottin, Frédéric; Mareljic, Nikola; Czuppa, Mareike; Farny, Daniel; Hartmann, Hannelore; Michaelsen, Meike; Arzberger, Thomas; Hartl, F Ulrich; Hipp, Mark S; Edbauer, Dieter

Cell‐to‐cell transmission of C9orf72 poly‐(Gly‐Ala) triggers key features of ALS / FTD

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Springer Science and Business Media LLC, 2020

Published in: The EMBO Journal
LaClair, Katherine D.; Zhou, Qihui; Michaelsen, Meike; Wefers, Benedikt; Brill, Monika S.; Janjic, Aleksandar; Rathkolb, Birgit; Farny, Daniel; Cygan, Mikolaj; de Angelis, Martin Hrabe; Wurst, Wolfgang; Neumann, Manuela; Enard, Wolfgang; Misgeld, Thomas; Arzberger, Thomas; Edbauer, Dieter

Congenic expression of poly-GA but not poly-PR in mice triggers selective neuron loss and interferon responses found in C9orf72 ALS

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Springer Science and Business Media LLC, 2020

Published in: Acta Neuropathologica
Zhou, Qihui; Lehmer, Carina; Michaelsen, Meike; Mori, Kohji; Alterauge, Dominik; Baumjohann, Dirk; Schludi, Martin H; Greiling, Johanna; Farny, Daniel; Flatley, Andrew; Feederle, Regina; May, Stephanie; Schreiber, Franziska; Arzberger, Thomas; Kuhm, Christoph; Klopstock, Thomas; Hermann, Andreas; Haass, Christian; Edbauer, Dieter

Antibodies inhibit transmission and aggregation of C9orf72 poly‐ GA dipeptide repeat proteins

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Springer Science and Business Media LLC, 2017

Published in: EMBO Molecular Medicine
Riemenschneider, Henrick; Simonetti, Francesca; Sheth, Udit; Katona, Eszter; Roth, Stefan; Hutten, Saskia; Farny, Daniel; Michaelsen, Meike; Nuscher, Brigitte; Schmidt, Michael K.; Flatley, Andrew; Schepers, Aloys; Gruijs da Silva, Lara A.; Zhou, Qihui; Klopstock, Thomas; Liesz, Arthur; Arzberger, Thomas; Herms, Jochen; Feederle, Regina; Gendron, Tania F.; Dormann, Dorothee; Edbauer, Dieter

Targeting the glycine-rich domain of TDP-43 with antibodies prevents its aggregation in vitro and reduces neurofilament levels in vivo

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Springer Science and Business Media LLC, 2023

Published in: Acta Neuropathologica Communications
Schludi, Martin H.; Becker, Lore; Garrett, Lillian; Gendron, Tania F.; Zhou, Qihui; Schreiber, Franziska; Popper, Bastian; Dimou, Leda; Strom, Tim M.; Winkelmann, Juliane; von Thaden, Anne; Rentzsch, Kristin; May, Stephanie; Michaelsen, Meike; Schwenk, Benjamin M.; Tan, Jing; Schoser, Benedikt; Dieterich, Marianne; Petrucelli, Leonard; Hölter, Sabine M.; Wurst, Wolfgang; Fuchs, Helmut; Gailus-Durner, Valerie; de Angelis, Martin Hrabe; [...]

Spinal poly-GA inclusions in a C9orf72 mouse model trigger motor deficits and inflammation without neuron loss

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Springer Science and Business Media LLC, 2017

Published in: Acta Neuropathologica
Schwenk, Benjamin M; Hartmann, Hannelore; Serdaroglu, Alperen; Schludi, Martin H; Hornburg, Daniel; Meissner, Felix; Orozco, Denise; Colombo, Alessio; Tahirovic, Sabina; Michaelsen, Meike; Schreiber, Franziska; Haupt, Simone; Peitz, Michael; Brüstle, Oliver; Küpper, Clemens; Klopstock, Thomas; Otto, Markus; Ludolph, Albert C; Arzberger, Thomas; Kuhn, Peer‐Hendrik; Edbauer, Dieter

TDP‐43 loss of function inhibits endosomal trafficking and alters trophic signaling in neurons

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Springer Science and Business Media LLC, 2016

Published in: The EMBO Journal
Rüddel, Hendrik; Thomas-Rüddel, Daniel O.; Reinhart, Konrad; Bach, Friedhelm; Gerlach, Herwig; Lindner, Matthias; Marshall, John C.; Simon, Philipp; Weiss, Manfred; Bloos, Frank; Schwarzkopf, Daniel; Marx, Gernot; Schindler, Achim; Schürholz, Tobias; Schlegel‑Höfner, Heike; Lehmann, Gunther; Sander, Annett; Friese, Steffen; Scholz, Christian; Fischer, Pia; Fuchs, Christina; Becher, Lutz; Salewsky, Norbert; Schreiber, Torsten; [...]

Adverse effects of delayed antimicrobial treatment and surgical source control in adults with sepsis: results of a planned secondary analysis of a cluster-randomized controlled trial

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Springer Science and Business Media LLC, 2022

Published in: Critical Care
Schwarzkopf, Daniel; Matthaeus-Kraemer, Claudia Tanja; Thomas-Rüddel, Daniel O.; Rüddel, Hendrik; Poidinger, Bernhard; Bach, Friedhelm; Gerlach, Herwig; Gründling, Matthias; Lindner, Matthias; Scheer, Christian; Simon, Philipp; Weiss, Manfred; Reinhart, Konrad; Bloos, Frank; Marx, Gernot; Schindler, Achim; Schürholz, Tobias; Schlegel‑Höfner, Heike; Lehmann, Gunther; Sander, Annett; Friese, Steffen; Scholz, Christian; Fischer, Pia; Fuchs, Christina; [...]

A multifaceted educational intervention improved anti-infectious measures but had no effect on mortality in patients with severe sepsis

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Springer Science and Business Media LLC, 2022

Published in: Scientific Reports
Thomas-Rüddel, Daniel O.; Hoffmann, Peter; Schwarzkopf, Daniel; Scheer, Christian; Bach, Friedhelm; Komann, Marcus; Gerlach, Herwig; Weiss, Manfred; Lindner, Matthias; Rüddel, Hendrik; Simon, Philipp; Kuhn, Sven-Olaf; Wetzker, Reinhard; Bauer, Michael; Reinhart, Konrad; Bloos, Frank; Marx, Gernot; Schindler, Achim; Schürholz, Tobias; Schlegel-Höfner, Heike; Lehmann, Gunther; Sander, Annett; Friese, Steffen; Scholz, Christian; [...]

Fever and hypothermia represent two populations of sepsis patients and are associated with outside temperature

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Springer Science and Business Media LLC, 2021

Published in: Critical Care
Warrington, Nicole M.; Beaumont, Robin N.; Horikoshi, Momoko; Day, Felix R.; Helgeland, Øyvind; Laurin, Charles; Bacelis, Jonas; Peng, Shouneng; Hao, Ke; Feenstra, Bjarke; Wood, Andrew R.; Mahajan, Anubha; Tyrrell, Jessica; Robertson, Neil R.; Rayner, N. William; Qiao, Zhen; Moen, Gunn-Helen; Vaudel, Marc; Marsit, Carmen J.; Chen, Jia; Nodzenski, Michael; Schnurr, Theresia M.; Zafarmand, Mohammad H.; Bradfield, Jonathan P.; [...]

Maternal and fetal genetic effects on birth weight and their relevance to cardio-metabolic risk factors

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Springer Science and Business Media LLC, 2019

Published in: Nature Genetics

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