University thesis:
Dissertation, Georg-August-Universität Göttingen, 2019
Footnote:
Description:
Reactive oxygen species (ROS) have been recognized to play important roles as messenger molecules. They are involved in the etiology and progression of cardiovascular diseases such as myocardial infarction, cardiac hypertrophy or fibrosis. Investigation of reactive oxygen species and cellular redox alterations has been methodologically challenging. Genetically encoded redox sensors make dynamic measurements of ROS and involved buffering systems in living cells possible. They can be targeted to specific cellular organelles and report compartment specific redox changes. Analysis of sensor res...