• Media type: E-Book; Thesis
  • Title: Poly(lactide)-based amphiphilic block copolymers : self-assembly and stereocomplexation in aqueous media
  • Contributor: Noack, Sebastian [VerfasserIn]; Schlaad, Helmut [AkademischeR BetreuerIn]
  • Corporation: Universität Potsdam
  • Published: Potsdam, 2019
  • Other titles: Übersetzung des Haupttitels: Polylactid-basierte amphiphile Blockcopolymere
  • Extent: 1 Online-Ressource (xvii, 148 Seiten, 13192 KB); Illustrationen, Diagramme
  • Language: English
  • DOI: 10.25932/publishup-43616
  • Identifier:
  • Origination:
  • Keywords: Polymilchsäure > Polyethylenglykole > Blockcopolymere > Ringöffnungspolymerisation > Selbstorganisation
  • Description: Due to its bioavailability and (bio)degradability, poly(lactide) (PLA) is an interesting polymer that is already being used as packaging material, surgical seam, and drug delivery system. Dependent on various parameters such as polymer composition, amphiphilicity, sample preparation, and the enantiomeric purity of lactide, PLA in an amphiphilic block copolymer can affect the self-assembly behavior dramatically. However, sizes and shapes of aggregates have a critical effect on the interactions between biological and drug delivery systems, where the general understanding of these polymers and their ability to influence self-assembly is of significant interest in science. The first part of this thesis describes the synthesis and study of a series of linear poly(L-lactide) (PLLA) and poly(D-lactide) (PDLA)-based amphiphilic block copolymers with varying PLA (hydrophobic), and poly(ethylene glycol) (PEG) (hydrophilic) chain lengths and different block copolymer sequences (PEG-PLA and PLA-PEG). [...]
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  • Access State: Open Access