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Media type:
Book
Title:
Highlights in bioorganic chemistry
:
methods and applications
Contains:
pt. 1. Biomolecules and their conformation. Equilibria of RNA secondary structures / Ronald Micura, Claudia Höbartner -- Synthesis and application of proline and pipecolic acid derivatives : tools for stabilization of peptide secondary structures / Wolfgang Maison -- Stabilization of peptide microstructures by coordination of metal ions / Markus Albrecht -- Conformational restriction of sphingolipids / Thomas Kolter -- [Beta]-amino acids in nature / Franz von Nussbaum, Peter Spiteller -- Biosynthesis of [Beta]-amino acids / Peter Spiteller, Franz von Nussbaum -- pt. 2. Non-covalent intermolecular interactions. Carbohydrate recognition by artificial receptors / Arne Lützen -- Cyclopeptides as macrocyclic host molecules for charged guests / Stephen Kubik -- Bioorganic receptors for amino acids and peptides : combining rational design with combinatorial chemistry / Carsten Schmuck, Wolfgang Wienand, Lars Geiger -- Artificial receptors for the stabilization of [beta]-sheet structures / Thomas Schrader, Markus Wehner, Petra Rzepecki -- Evaluation of the DNA-binding properties of cationic dyes by absorption and emission spectroscopy / Heiko Ihmels, Katja Faulhaber, Giampietro Viola -- Interaction of nitrogen monoxide and peroxynitrite with hemoglobin and myoglobin / Susanna Herold -- Synthetic approaches to study multivalent carbohydrate-lectin interactions / Valentin Wittmann -- pt. 3. Studies in drug developments. Building a bridge between chemistry and biology : molecular forceps that inhibit the farnesylation of RAS / Hans Peter Nestler -- Inhibitors against human mast cell tryptase : a potential approach to attack asthma? / Thomas J. Martin -- Preparation of novel steroids by microbiological and combinatorial chemistry / Christoph Huwe, Hermann Künzer, Ludwig Zorn -- Enantiomeric nucleic acids, spiegelmers / Sven Klussmann -- Aspartic proteases involved in Alzheimer's disease / Boris Schmidt, Alexander Siegler -- Novel polymer and linker reagents for the preparation of protease-inhibitor libraries / Jörg Rademann -- pt. 4. Studies in diagnostic developments. Selectivity of DNA replication / Andreas Marx, Daniel Summerer, Michael Strerath -- Homogeneous DNA detection / Oliver Seitz -- Exploring the capabilities of nucleic acid polymerases by use of directed evolution / Susanne Brakmann, Marina Schlicke -- Labeling of fusion proteins with small molecules in vivo / Susanne Gendreizig ... [et al.] -- Oxidative splitting of pyrimidine cyclobutane dimers / Uta Wille -- Charge transfer in DNA / Hans-Achim Wagenknecht -- pt. 5. Catalysis. Protease-catalyzed formation of C-N bonds / Frank Bordusa -- Twin ribozymes / Sabine Müller ... [et al.] -- RNA as a catalyst : the Diels-Alderase ribozyme / Sonja Keiper ... [et al.] -- Combinatorial methods for the discovery of catalysts / Helma Wennemers -- pt. 6. Methodology, bioengineering and bioinspired assemblies. Linkers for solid-phase synthesis / Kerstin Knepper, Carmen Gil, Stefan Bräse -- Small molecule arrays / Rolf Breinbauer, Maja Köhn, Carsten Peters -- Biotechnological production of D-pantothenic acid and its precursor D-pantolactone / Maria Kessler -- Microbially produced functionalized cyclohexadiene-trans-diols as a new class of chiral building blocks in organic synthesis : on the way to green and combinatorial chemistry / Volker Lorbach ... [et al.] -- Artificial molecular rotary motors based on rotaxanes / Thorsten Felder, Christoph A. Schalley
Literaturangaben
Description:
This is a fascinating introduction to the topic. Spanning the spectrum of nucleic acid chemistry, carbohydrates, peptides, molecular recognition, biosynthesis and natural biosynthesis, right up to medical and biophysical chemistry, the book provides advanced students and those already working in the field with a balanced overview. In more than 30 contributions, a new generation of recognized scientists gives an account of the latest research in such areas as * Artificial receptors for the stabilization of ß-sheet structures * Carbohydrate recognition by artificial receptors * Combinatorial chemistry as a tool for the discovery of catalysts * The interaction of NO and peroxynitrite with hemoglobin and myoglobin * Inhibitors against human mast-cell-tryptase as a potential approach to conquering asthma * The selectivity of DNA replication. A readily accessible survey for everyone wishing to stay abreast of developments. With a Foreword by Ronald Breslow.