Drug repositioning: bringing new life to shelved assets and existing drugs - SLUB Dresden

Media type: Book

Title: Drug repositioning : bringing new life to shelved assets and existing drugs

Contains: Drug repositioning : the business case and current strategies to repurpose shelved candidates and marketed drugs / John Arrowsmith and Richard HarrisonOpportunities and challenges associated with developing additional indications for clinical development candidates and marketed drugs / Donald Frail and Michael Barratt -- Clinical and operational considerations in repositioning marketed drugs and drug candidates / Damian O'Connell, David Sequeira, and Maria Miller -- Regulatory considerations and strategies for drug repositioning / Ken Phelps -- Computational and bioinformatic strategies for drug repositioning / Richard Mazzarella and Craig Webb -- Mining scientific and clinical databases to identify novel uses for existing drugs / Christos Andronis ... [et al.] -- Predicting the polypharmacology of drugs : identifying new uses through chemoinformatics, structural informatics and molecular modeling based approaches / Li Xie ... [et al.] -- Systematic phenotypic screening for novel synergistic combinations: a new paradigm for repositioning existing drugs / Margaret Lee -- Phenotypic in vivo screening to identify new, unpredicted indications for existing drugs and drug candidates / Michael Saporito, Christopher Lipinski, and Andrew Reaume -- Old drugs yield new discoveries : examples from the prodrug, chiral switch and site-selective deuteration strategies / Adam Morgan ... [et al.] -- Repurposing drugs for tropical diseases : case studies and open-source screening initiatives / Curtis Chong -- Drug repositioning efforts by non-profit foundations -- Business development strategies in the repositioning industry / Aris Persidis and Elizabeth Stark -- A case study in drug repositioning : Sosei / Akinori Mochizuki and Makiko Aoyama.
Drug repositioning : the business case and current strategies to repurpose shelved candidates and marketed drugs / John Arrowsmith and Richard Harrison
Opportunities and challenges associated with developing additional indications for clinical development candidates and marketed drugs / Donald Frail and Michael Barratt
Clinical and operational considerations in repositioning marketed drugs and drug candidates / Damian O'Connell, David Sequeira, and Maria Miller
Regulatory considerations and strategies for drug repositioning / Ken Phelps
Computational and bioinformatic strategies for drug repositioning / Richard Mazzarella and Craig Webb
Mining scientific and clinical databases to identify novel uses for existing drugs / Christos Andronis ... [et al.]
Predicting the polypharmacology of drugs : identifying new uses through chemoinformatics, structural informatics and molecular modeling based approaches / Li Xie ... [et al.]
Systematic phenotypic screening for novel synergistic combinations: a new paradigm for repositioning existing drugs / Margaret Lee
Phenotypic in vivo screening to identify new, unpredicted indications for existing drugs and drug candidates / Michael Saporito, Christopher Lipinski, and Andrew Reaume
Old drugs yield new discoveries : examples from the prodrug, chiral switch and site-selective deuteration strategies / Adam Morgan ... [et al.]
Repurposing drugs for tropical diseases : case studies and open-source screening initiatives / Curtis Chong
Drug repositioning efforts by non-profit foundations ; Business development strategies in the repositioning industry / Aris Persidis and Elizabeth Stark
A case study in drug repositioning : Sosei / Akinori Mochizuki and Makiko Aoyama.

Contributor: Barratt, Michael J. [Editor] ; Frail, Donald E. [Other]

Published: Hoboken, NJ: Wiley, c 2012

Extent: XX, 477 S.; Ill., graph. Darst; 24 cm

Language: English

ISBN: 9780470878279; 0470878274

RVK notation: VS 5350 : Allgemeines

Keywords: Arzneimittelentwicklung

Origination:

Footnote: Includes bibliographical references and index

Drug repositioning

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