Description:
Tumor cells are characterized by intrinsic proteotoxic stress and the accumulation of mutated proteins. Therefore, malignant cells depend on the activity of heat shock protein 90 (HSP90) much more than normal cells to maintain a functionally intact proteome. Thus, the inhibition of HSP90 by small molecules is currently being evaluated as a new approach to cancer therapy. One of the most promising drugs of this class is ganetespib, which is currently in intensive clinical trials. We analyzed the susceptibility of colorectal cancer (CRC) cell lines to ganetespib and recorded large differences...