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Media type:
E-Article
Title:
Prospective evaluation of S100A12 and S100A8/A9 (calprotectin) in dogs with sepsis or the systemic inflammatory response syndrome
Contributor:
Thames, Brittany E.
[Author];
Barr, James W.
[Author];
Suchodolski, Jan S.
[Author];
Steiner, Jörg M.
[Author];
Heilmann, Romy M.
[Author]
Description:
Pattern recognition receptors (e.g., S100A12 or S100A8/A9) hold promise as inflammatory biomarkers. Weprospectively determined and compared serum S100A12 and S100A8/A9 concentrations in dogs with sepsis (n = 11) orsystemic inflammatory response syndrome (SIRS; n = 8) over a 3-d period with each other, healthy controls (n = 50), and otherclinical and clinicopathologic variables. Serum S100A12 and S100A8/A9 concentrations were significantly higher in dogswith sepsis or SIRS (all p < 0.05) at the time of hospital admission (day 1) compared to healthy controls, with no differencesbetween patient groups. However, septic dogs had significantly lower serum S100A12 concentrations on day 2 and day 3 (bothp < 0.05) compared to dogs with SIRS. Likewise, dogs with sepsis had significantly lower S100A8/A9 concentrations on day2 (p < 0.05). Neither serum S100A12 nor S100A8/A9 concentrations were associated with survival to discharge. Our resultssuggest a differential expression of the S100/calgranulins between dogs with sepsis and those with SIRS. Serum S100A12 orS100A8/A9 concentration at the time of hospital admission did not differentiate dogs with sepsis from those with SIRS, butthe trend of S100/calgranulin concentrations during the following 24–48 h may be a useful surrogate marker for differentiatingsepsis from SIRS.