> Details
Ombrello, Michael J.;
Remmers, Elaine F.;
Tachmazidou, Ioanna;
Grom, Alexei;
Foell, Dirk;
Haas, Johannes-Peter;
Martini, Alberto;
Gattorno, Marco;
Özen, Seza;
Prahalad, Sampath;
Zeft, Andrew S.;
Bohnsack, John F.;
Mellins, Elizabeth D.;
Ilowite, Norman T.;
Russo, Ricardo;
Len, Claudio;
Hilario, Maria Odete E.;
Oliveira, Sheila;
Yeung, Rae S. M.;
Rosenberg, Alan;
Wedderburn, Lucy R.;
Anton, Jordi;
Schwarz, Tobias;
Hinks, Anne;
[...]
HLA-DRB1*11and variants of the MHC class II locus are strong risk factors for systemic juvenile idiopathic arthritis
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- Media type: E-Article
- Title: HLA-DRB1*11and variants of the MHC class II locus are strong risk factors for systemic juvenile idiopathic arthritis
- Contributor: Ombrello, Michael J.; Remmers, Elaine F.; Tachmazidou, Ioanna; Grom, Alexei; Foell, Dirk; Haas, Johannes-Peter; Martini, Alberto; Gattorno, Marco; Özen, Seza; Prahalad, Sampath; Zeft, Andrew S.; Bohnsack, John F.; Mellins, Elizabeth D.; Ilowite, Norman T.; Russo, Ricardo; Len, Claudio; Hilario, Maria Odete E.; Oliveira, Sheila; Yeung, Rae S. M.; Rosenberg, Alan; Wedderburn, Lucy R.; Anton, Jordi; Schwarz, Tobias; Hinks, Anne; [...]
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Published:
Proceedings of the National Academy of Sciences, 2015
- Published in: Proceedings of the National Academy of Sciences, 112 (2015) 52, Seite 15970-15975
- Language: English
- DOI: 10.1073/pnas.1520779112
- ISSN: 1091-6490; 0027-8424
- Origination:
- Footnote:
- Description: SignificanceTo determine whether genetic variation within the MHC locus influences the risk of developing systemic juvenile idiopathic arthritis (sJIA), we examined a dense set of MHC region single nucleotide polymorphisms, classic HLA alleles, and the individual amino acids of HLA molecules in nine independent sJIA case-control populations. Association testing revealed that genetic variants within the MHC class II gene cluster significantly influenced sJIA risk in every study population. The strongest risk factor for sJIA wasHLA-DRB1*11, which conferred at least a two-fold increase in disease risk in each population studied. These data implicate the interaction of antigen presenting cells with T cells in the pathogenesis of sJIA.
- Access State: Open Access