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Lu, Wan-Hsuan; de Souto Barreto, Philipe; Rolland, Yves; Bouyahia, Ali; Fischer, Clara; Mangin, Jean-François; Giudici, Kelly V; Vellas, Bruno; Vellas, Bruno; Guyonnet, Sophie; Carrié, Isabelle; Brigitte, Lauréane; Faisant, Catherine; Lala, Françoise; Delrieu, Julien; Villars, Hélène; Combrouze, Emeline; Badufle, Carole; Zueras; Methodology, Audrey; analysis, statistical; Andrieu, Sandrine; Cantet, Christelle; Morin, Christophe; Abellan Van Kan, Gabor; [...]

Biological and Neuroimaging Markers as Predictors of 5-Year Incident Frailty in Older Adults: A Secondary Analysis of the MAPT Study

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  • Media type: E-Article
  • Title: Biological and Neuroimaging Markers as Predictors of 5-Year Incident Frailty in Older Adults: A Secondary Analysis of the MAPT Study
  • Contributor: Lu, Wan-Hsuan; de Souto Barreto, Philipe; Rolland, Yves; Bouyahia, Ali; Fischer, Clara; Mangin, Jean-François; Giudici, Kelly V; Vellas, Bruno; Vellas, Bruno; Guyonnet, Sophie; Carrié, Isabelle; Brigitte, Lauréane; Faisant, Catherine; Lala, Françoise; Delrieu, Julien; Villars, Hélène; Combrouze, Emeline; Badufle, Carole; Zueras; Methodology, Audrey; analysis, statistical; Andrieu, Sandrine; Cantet, Christelle; Morin, Christophe; Abellan Van Kan, Gabor; [...]
  • imprint: Oxford University Press (OUP), 2021
  • Published in: The Journals of Gerontology: Series A
  • Language: English
  • DOI: 10.1093/gerona/glaa296
  • ISSN: 1079-5006; 1758-535X
  • Keywords: Geriatrics and Gerontology ; Aging
  • Origination:
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  • Description: <jats:title>Abstract</jats:title> <jats:sec> <jats:title>Background</jats:title> <jats:p>This study aims to investigate the predictive value of biological and neuroimaging markers to determine incident frailty among older people for a period of 5 years.</jats:p> </jats:sec> <jats:sec> <jats:title>Methods</jats:title> <jats:p>We included 1394 adults aged 70 years and older from the Multidomain Alzheimer Preventive Trial, who were not frail at baseline (according to Fried’s criteria) and who had at least 1 post-baseline measurement of frailty. Participants who progressed to frailty during the 5-year follow-up were categorized as “incident frailty” and those who remained non-frail were categorized as “without frailty.” The differences of baseline biochemical factors (25-hydroxyvitamin D, homocysteine, omega-3 index, C-reactive protein), other biological markers (Apolipoprotein E genotypes, amyloid-β deposits), and neuroimaging data (gray matter volume, hippocampal volume, white matter hyperintensities) were compared between groups. Cox proportional hazard model was used to evaluate the associations between biomarkers and incident frailty.</jats:p> </jats:sec> <jats:sec> <jats:title>Results</jats:title> <jats:p>A total of 195 participants (14.0%) became frail over 5 years. Although 25-hydroxyvitamin D deficiency, homocysteine levels, low-grade inflammation (persistently increased C-reactive protein 3–10 mg/L), gray matter, and hippocampal volume were significantly associated with incident frailty in unadjusted models, these associations disappeared after adjustment for age, sex, and other confounders. Omega-3 index was the sole marker that presented a trend of association with incident frailty (hazard ratio: 0.92; 95% confidence interval: 0.83–1.01; p = .082).</jats:p> </jats:sec> <jats:sec> <jats:title>Conclusions</jats:title> <jats:p>This study failed to identify biomarkers able to predict frailty incidence in community-dwelling older adults for a period of 5 years. Further longitudinal research with multiple measurements of biomarkers and frailty is needed to evaluate the long-term relationships between changes in biomarkers levels and frailty evolution.</jats:p> </jats:sec>