Abstract:
<jats:sec>
<jats:title>Purpose of review</jats:title>
<jats:p>BRAF/MEK inhibitor has changed the treatment landscape in patients with advanced and metastatic melanoma with prolonged overall survival and progression-free survival. Since three treatment combinations exist with similar efficacy therapy decisions are often made based on the side effect profile. Additionally, on-target side effects or class effects have to be properly managed to ensure treatment adherence.</jats:p>
</jats:sec>
<jats:sec>
<jats:title>Recent findings</jats:title>
<jats:p>Sequential treatment with BRAF/MEK inhibition and immunotherapy might increase toxicity with a sepsis-like syndrome and triple therapy with concomitant BRAF/MEK inhibition and anti-PD1/PD-L1 antibody therapy induces severe side effects in the vast majority of patients.</jats:p>
</jats:sec>
<jats:sec>
<jats:title>Summary</jats:title>
<jats:p>Toxicity of combination therapy with BRAF/MEK inhibitors is generally manageable, reversible and infrequently associated with treatment discontinuation. In case of persisting off-target effects the change to another combination therapy can resolve side effects.</jats:p>
</jats:sec>
Description:
<jats:sec>
<jats:title>Purpose of review</jats:title>
<jats:p>BRAF/MEK inhibitor has changed the treatment landscape in patients with advanced and metastatic melanoma with prolonged overall survival and progression-free survival. Since three treatment combinations exist with similar efficacy therapy decisions are often made based on the side effect profile. Additionally, on-target side effects or class effects have to be properly managed to ensure treatment adherence.</jats:p>
</jats:sec>
<jats:sec>
<jats:title>Recent findings</jats:title>
<jats:p>Sequential treatment with BRAF/MEK inhibition and immunotherapy might increase toxicity with a sepsis-like syndrome and triple therapy with concomitant BRAF/MEK inhibition and anti-PD1/PD-L1 antibody therapy induces severe side effects in the vast majority of patients.</jats:p>
</jats:sec>
<jats:sec>
<jats:title>Summary</jats:title>
<jats:p>Toxicity of combination therapy with BRAF/MEK inhibitors is generally manageable, reversible and infrequently associated with treatment discontinuation. In case of persisting off-target effects the change to another combination therapy can resolve side effects.</jats:p>
</jats:sec>