Description:
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<jats:title>Abstract</jats:title>
<jats:p>The aim of this study was to test the hypothesis that computed tomography texture analysis (CTTA) is accurate for response assessment of Hodgkin lymphoma (HL).</jats:p>
<jats:p>A total of 100 patients with HL were identified. CTTA in baseline and interim staging was performed generating volume of interests in lymphoma tissue from which CTTA features including 1st, 2nd, and higher order textural features were extracted. Baseline and interim 2-deoxy-fluor-glucose positron emission tomography results were used to determine therapy response and compared to CTTA in terms of patient outcome.</jats:p>
<jats:p>At interim, 1st-order features yielded a significant drop (e.g., entropy of heterogeneity, <jats:italic toggle="yes">P</jats:italic> = .01) or a significant rise (deviation, <jats:italic toggle="yes">P</jats:italic> < .001), whereas 2nd and higher order features decreased (e.g., entropy of co-occurrence matrix, <jats:italic toggle="yes">P</jats:italic> < .001). Patients achieving complete remission at end of treatment had a significantly lower entropy of heterogeneity at baseline and interim compared to patients achieving partial remission (<jats:italic toggle="yes">P</jats:italic> < .05).</jats:p>
<jats:p>CT textural features change in parallel to metabolic therapy response, and are therefore a feasible diagnostic tool for a more accurate response assessment of HL.</jats:p>
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