Effect of Liposuction on Body Weight and Serum Concentrations of Leptin, Lipids, Glucose, and Insulin: A Meta-Analysis

Media type: E-Article
Title: Effect of Liposuction on Body Weight and Serum Concentrations of Leptin, Lipids, Glucose, and Insulin: A Meta-Analysis
Contributor: Gómez-Sámano, Miguel Ángel; Guerrero-Castillo, Anna Paula; Abarca-Arroyo, Jorge Antonio; Albuja-González, Elena Cristina; García-Bonilla, Hans Alessandro; Espinosa-Salazar, Héctor Donaldo; Villanueva-Gómez-Crespo, María Teresa; Catzin-Kuhlmann, Andrés; López-Gatell, Hugo; Tlapanco-Beltrán, Cristina Aurora; Vera-Zertuche, Juan Mauricio; León-Suárez, Andrés; Telich-Tarriba, José Eduardo; Cuevas-Ramos, Daniel; Gómez-Pérez, Francisco J.; Gulias-Herrero, Alfonso
Published: Ovid Technologies (Wolters Kluwer Health), 2023
Published in: Plastic & Reconstructive Surgery
Extent: 402e-411e
Language: English
DOI: 10.1097/prs.0000000000009913
ISSN: 0032-1052
Keywords: Surgery
Abstract: <jats:sec> <jats:title>Background:</jats:title> <jats:p>Abdominal obesity has been associated with an increased risk of insulin resistance, metabolic syndrome, and diabetes. Central fat removal procedures such as liposuction, lipectomy, and abdominoplasty are among the most common surgical procedures. The impact of the latter on the former is controversial and understudied. The authors aimed to explore the effect of subcutaneous fat elimination procedures on insulin resistance measures and adipokine levels.</jats:p> </jats:sec> <jats:sec> <jats:title>Methods:</jats:title> <jats:p>Relevant studies regarding the effects of surgical subcutaneous fat removal on glucose, insulin, adipokines, and lipid metabolism, as well as blood pressure, were identified by searching PubMed and Ovid–Cochrane without limits in date, type of publication, or language. After the selection process, 24 studies were obtained. The results of the articles were summarized using descriptive statistics. For the final analysis, a randomized effects model was used to evaluate heterogeneity; averages and meta-analytic differences were expressed with a confidence interval of 95%.</jats:p> </jats:sec> <jats:sec> <jats:title>Results:</jats:title> <jats:p>All studies reported a reduction in weight (−2.64 kg; 95% CI, −4.32 to −0.96; <jats:italic toggle="yes">P</jats:italic> = 0.002; I<jats:sup>2</jats:sup> = 36%; <jats:italic toggle="yes">P</jats:italic> of I<jats:sup>2</jats:sup> < 0.001) and body mass index after liposuction. A significant improvement in triglycerides (−10.06 mg/dL; 95% CI, −14.03 to −6.09; <jats:italic toggle="yes">P</jats:italic> < 0.001; I<jats:sup>2</jats:sup> = 48%; <jats:italic toggle="yes">P</jats:italic> of I<jats:sup>2</jats:sup> = 0.05), serum glucose concentration (−4.25 mg/dL; 95% CI, −5.93 to −2.56; <jats:italic toggle="yes">P</jats:italic> < 0.001; I<jats:sup>2</jats:sup> = 68%; <jats:italic toggle="yes">P</jats:italic> of I<jats:sup>2</jats:sup> < 0.001), serum insulin concentration (−2.86 μIU/mL; 95% CI, −3.75 to −1.97; <jats:italic toggle="yes">P</jats:italic> < 0.001; I<jats:sup>2</jats:sup> = 59%; <jats:italic toggle="yes">P</jats:italic> of I<jats:sup>2</jats:sup> = 0.003), and serum leptin concentration (−7.70 ng/mL; 95% CI, −11.49 to −3.92; <jats:italic toggle="yes">P</jats:italic> = 0.0001; I<jats:sup>2</jats:sup> = 96%; <jats:italic toggle="yes">P</jats:italic> of I<jats:sup>2</jats:sup> < 0.001) was consistently observed.</jats:p> </jats:sec> <jats:sec> <jats:title>Conclusion:</jats:title> <jats:p>In addition to weight loss, there is a significant decrease in leptin, triglyceride, glucose, and insulin serum concentrations after liposuction, a fact that should be considered in future discussions.</jats:p> </jats:sec>
Description: <jats:sec>
<jats:title>Background:</jats:title>
<jats:p>Abdominal obesity has been associated with an increased risk of insulin resistance, metabolic syndrome, and diabetes. Central fat removal procedures such as liposuction, lipectomy, and abdominoplasty are among the most common surgical procedures. The impact of the latter on the former is controversial and understudied. The authors aimed to explore the effect of subcutaneous fat elimination procedures on insulin resistance measures and adipokine levels.</jats:p>
</jats:sec>
<jats:sec>
<jats:title>Methods:</jats:title>
<jats:p>Relevant studies regarding the effects of surgical subcutaneous fat removal on glucose, insulin, adipokines, and lipid metabolism, as well as blood pressure, were identified by searching PubMed and Ovid–Cochrane without limits in date, type of publication, or language. After the selection process, 24 studies were obtained. The results of the articles were summarized using descriptive statistics. For the final analysis, a randomized effects model was used to evaluate heterogeneity; averages and meta-analytic differences were expressed with a confidence interval of 95%.</jats:p>
</jats:sec>
<jats:sec>
<jats:title>Results:</jats:title>
<jats:p>All studies reported a reduction in weight (−2.64 kg; 95% CI, −4.32 to −0.96; <jats:italic toggle="yes">P</jats:italic> = 0.002; I<jats:sup>2</jats:sup> = 36%; <jats:italic toggle="yes">P</jats:italic> of I<jats:sup>2</jats:sup> < 0.001) and body mass index after liposuction. A significant improvement in triglycerides (−10.06 mg/dL; 95% CI, −14.03 to −6.09; <jats:italic toggle="yes">P</jats:italic> < 0.001; I<jats:sup>2</jats:sup> = 48%; <jats:italic toggle="yes">P</jats:italic> of I<jats:sup>2</jats:sup> = 0.05), serum glucose concentration (−4.25 mg/dL; 95% CI, −5.93 to −2.56; <jats:italic toggle="yes">P</jats:italic> < 0.001; I<jats:sup>2</jats:sup> = 68%; <jats:italic toggle="yes">P</jats:italic> of I<jats:sup>2</jats:sup> < 0.001), serum insulin concentration (−2.86 μIU/mL; 95% CI, −3.75 to −1.97; <jats:italic toggle="yes">P</jats:italic> < 0.001; I<jats:sup>2</jats:sup> = 59%; <jats:italic toggle="yes">P</jats:italic> of I<jats:sup>2</jats:sup> = 0.003), and serum leptin concentration (−7.70 ng/mL; 95% CI, −11.49 to −3.92; <jats:italic toggle="yes">P</jats:italic> = 0.0001; I<jats:sup>2</jats:sup> = 96%; <jats:italic toggle="yes">P</jats:italic> of I<jats:sup>2</jats:sup> < 0.001) was consistently observed.</jats:p>
</jats:sec>
<jats:sec>
<jats:title>Conclusion:</jats:title>
<jats:p>In addition to weight loss, there is a significant decrease in leptin, triglyceride, glucose, and insulin serum concentrations after liposuction, a fact that should be considered in future discussions.</jats:p>
</jats:sec>
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