Media type: E-Article Title: Siloxane surfactants in polymer nanoparticles formulation Contributor: Racles, Carmen; Hamaide, Thierry; Ioanid, Aurelia Published: Wiley, 2006 Published in: Applied Organometallic Chemistry, 20 (2006) 4, Seite 235-245 Language: English DOI: 10.1002/aoc.1051 ISSN: 0268-2605; 1099-0739 Origination: Footnote: Description: AbstractCarbohydrate‐modified cyclosiloxanes were synthesized by hydrosilylation reactions of protected allyl‐monosaccharides and subsequent deprotection with a gel‐type ion exchanger. They were characterized by 1H and 13C‐NMR, FT‐IR, GPC and surface tension measurements. These compounds, as well as other water soluble, carboxylate‐based siloxanes were tested as stabilizers in nanoparticle formulations, with polydimethylsiloxane (PDMS), poly(ε‐caprolactone) (PCL) and UDEL polysulfone (PSF) as polymer cores. Owing to their low critical micelle concentrations (cmc), small amounts of surfactants were required. The particle size and granulometric distribution were measured by dynamic light scattering (DLS). Electron microscopy confirmed the DLS results and revealed aggregation phenomena in dry state, depending on the polymer core. In the tested conditions, the glass transition temperature of the polymer seems to be the driving force for the stability of dry nanoparticles. Copyright © 2006 John Wiley & Sons, Ltd.