Zhong, Sabilla;
Sauter, Paul F.;
Nieger, Martin;
Bräse, Stefan
Stereoselective Synthesis of Highly Functionalized Hydroindoles as Building Blocks for Rostratins B–D and Synthesis of the Pentacyclic Core of Rostratin C
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Media type:
E-Article
Title:
Stereoselective Synthesis of Highly Functionalized Hydroindoles as Building Blocks for Rostratins B–D and Synthesis of the Pentacyclic Core of Rostratin C
Contributor:
Zhong, Sabilla;
Sauter, Paul F.;
Nieger, Martin;
Bräse, Stefan
Description:
<jats:title>Abstract</jats:title><jats:p>The stereoselective synthesis of a variety of functionalized hydroindoles suitable as building blocks for thiodiketopiperazine natural products such as rostratins B–D is reported. The key precursor for all transformations is a previously reported hexahydroindole compound. All functional groups were installed with the desired stereochemistry and the feasibility of the synthetic strategy was exemplified by dimerization of two hydroindole units to form the pentacyclic <jats:italic>C</jats:italic><jats:sub>2</jats:sub>‐symmetric scaffold of rostratin C.</jats:p>