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Iojoiu, Cristina; Cade, David; Fessi, Hatem; Hamaide, Thierry

Synthesis of oligocaprolactone vinyl ether macromonomers and their use for indomethacin encapsulation in polymer nanoparticles based on polycaprolactone macromonomer–maleic anhydride–N‐vinyl pyrrolidone terpolymers

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  • Media type: E-Article
  • Title: Synthesis of oligocaprolactone vinyl ether macromonomers and their use for indomethacin encapsulation in polymer nanoparticles based on polycaprolactone macromonomer–maleic anhydride–N‐vinyl pyrrolidone terpolymers
  • Contributor: Iojoiu, Cristina; Cade, David; Fessi, Hatem; Hamaide, Thierry
  • Published: Wiley, 2006
  • Published in: Polymer International, 55 (2006) 2, Seite 222-228
  • Language: English
  • DOI: 10.1002/pi.1964
  • ISSN: 0959-8103; 1097-0126
  • Keywords: Polymers and Plastics ; Materials Chemistry ; Organic Chemistry
  • Origination:
  • Footnote:
  • Description: AbstractOligocaprolactone macromonomers functionalized with vinyl ether have been synthesized by polymerization of ε‐caprolactone in the presence of hydroxy ethyl or butyl vinyl ether and characterised by NMR and Maldi time‐of‐flight mass spectroscopy. These macromonomers have been copolymerized with maleic anhydride and N‐vinyl pyrrolidone to give terpolymers, which have been used to obtain nanoparticles by the phase‐separation‐dialysis method. Previously dissolving indomethacin in the terpolymer solution allows one to encapsulate the drug inside the nanoparticles. Copyright © 2005 Society of Chemical Industry