Published:
Springer Science and Business Media LLC, 2020
Published in:
Scientific Reports, 10 (2020) 1
Language:
English
DOI:
10.1038/s41598-019-56823-y
ISSN:
2045-2322
Origination:
Footnote:
Description:
AbstractThe spiny mouse,Acomys cahirinusdisplays a unique wound healing ability with regeneration of all skin components in a scar-free manner. To identify orchestrators of this regenerative response we have performed proteomic analyses of skin fromAcomysandMus musculusbefore and after wounding. Of the ~2000 proteins identified many are expressed at similar levels inAcomysandMus, but there are significant differences. Following wounding inMusthe complement and coagulation cascades, PPAR signaling pathway and ECM-receptor interactions predominate. InAcomys, other pathways predominate including the Wnt, MAPK, the ribosome, proteasome, endocytosis and tight junction pathways. Notable amongAcomysspecific proteins are several ubiquitin-associated enzymes and kinases, whereas inMusimmuno-modulation proteins characteristic of inflammatory response are unique or more prominent. ECM proteins such as collagens are more highly expressed inMus, but likely more important is the higher expression of matrix remodeling proteases inAcomys. Another distinctive difference betweenAcomysandMuslies in the macrophage-produced arginase 1 is found inMuswhereas arginase 2 is found inAcomys. Thus, we have identified several avenues for experimental approaches whose aim is to reduce the fibrotic response that the typical mammal displays in response to wounding.