Abstract:
<p>Superparamagnetic iron oxide nanoparticles with a dendritic polyglycerol (dPG) sulfate strongly bind to L- and P-selectin. Shielding of leukocytes reduces cell extravasation and binding to endothelial cells indicate inflammation specificity and thus, applicability as selective MRI contrast agent.</p>
Description:
<p>Superparamagnetic iron oxide nanoparticles with a dendritic polyglycerol (dPG) sulfate strongly bind to L- and P-selectin. Shielding of leukocytes reduces cell extravasation and binding to endothelial cells indicate inflammation specificity and thus, applicability as selective MRI contrast agent.</p>