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Media type:
E-Article
Title:
Loss of Slfn3 induces a sex-dependent repair vulnerability after 50% bowel resection
Contributor:
Vomhof-DeKrey, Emilie E.;
Lansing, Jack T.;
Darland, Diane C.;
Umthun, Josey;
Stover, Allie D.;
Brown, Christopher;
Basson, Marc D.
Published:
American Physiological Society, 2021
Published in:
American Journal of Physiology-Gastrointestinal and Liver Physiology, 320 (2021) 2, Seite G136-G152
Language:
English
DOI:
10.1152/ajpgi.00344.2020
ISSN:
0193-1857;
1522-1547
Origination:
Footnote:
Description:
The differentiating stimulus of Slfn3 signaling restrains an increase in mucosal mass after bowel resection, and there is a Slfn3-sex interaction regulating differentiation gene expression and intestinal adaptation. This current study highlights the combinatory effects of gender and Slfn3 genotype on the gene expression changes that contribute to the adaptation in intestinal cellular milleu (i.e. villus and crypt structure) which are utilized to compensate for the stress-healing response that the animals display in intestinal adaptation.