• Media type: E-Article
  • Title: Loss of Slfn3 induces a sex-dependent repair vulnerability after 50% bowel resection
  • Contributor: Vomhof-DeKrey, Emilie E.; Lansing, Jack T.; Darland, Diane C.; Umthun, Josey; Stover, Allie D.; Brown, Christopher; Basson, Marc D.
  • Published: American Physiological Society, 2021
  • Published in: American Journal of Physiology-Gastrointestinal and Liver Physiology, 320 (2021) 2, Seite G136-G152
  • Language: English
  • DOI: 10.1152/ajpgi.00344.2020
  • ISSN: 0193-1857; 1522-1547
  • Origination:
  • Footnote:
  • Description: The differentiating stimulus of Slfn3 signaling restrains an increase in mucosal mass after bowel resection, and there is a Slfn3-sex interaction regulating differentiation gene expression and intestinal adaptation. This current study highlights the combinatory effects of gender and Slfn3 genotype on the gene expression changes that contribute to the adaptation in intestinal cellular milleu (i.e. villus and crypt structure) which are utilized to compensate for the stress-healing response that the animals display in intestinal adaptation.
  • Access State: Open Access