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Media type:
E-Article
Title:
CFTR and lung homeostasis
Contributor:
Collawn, James F.;
Matalon, Sadis
Published:
American Physiological Society, 2014
Published in:
American Journal of Physiology-Lung Cellular and Molecular Physiology, 307 (2014) 12, Seite L917-L923
Language:
English
DOI:
10.1152/ajplung.00326.2014
ISSN:
1040-0605;
1522-1504
Origination:
Footnote:
Description:
CFTR is a cAMP-activated chloride and bicarbonate channel that is critical for lung homeostasis. Decreases in CFTR expression have dire consequences in cystic fibrosis (CF) and have been suggested to be a component of the lung pathology in chronic obstructive pulmonary disease. Decreases or loss of channel function often lead to mucus stasis, chronic bacterial infections, and the accompanying chronic inflammatory responses that promote progressive lung destruction, and, eventually in CF, lung failure. Here we discuss CFTR's functional role airway surface liquid hydration and pH, in regulation of other channels such as the epithelial sodium channel, and in regulating inflammatory responses in the lung.