> Details

Waterworth, Dawn M.; Ricketts, Sally L.; Song, Kijoung; Chen, Li; Zhao, Jing Hua; Ripatti, Samuli; Aulchenko, Yurii S.; Zhang, Weihua; Yuan, Xin; Lim, Noha; Luan, Jian'an; Ashford, Sofie; Wheeler, Eleanor; Young, Elizabeth H.; Hadley, David; Thompson, John R.; Braund, Peter S.; Johnson, Toby; Struchalin, Maksim; Surakka, Ida; Luben, Robert; Khaw, Kay-Tee; Rodwell, Sheila A.; Loos, Ruth J.F.; [...]

Genetic Variants Influencing Circulating Lipid Levels and Risk of Coronary Artery Disease

Reference
management

Bookmarks

Remove from
bookmarks

Share this on Whatsapp

Close

Bookmarks



You can manage bookmarks using lists, please log in to your user account for this.
  • Media type: E-Article
  • Title: Genetic Variants Influencing Circulating Lipid Levels and Risk of Coronary Artery Disease
  • Contributor: Waterworth, Dawn M.; Ricketts, Sally L.; Song, Kijoung; Chen, Li; Zhao, Jing Hua; Ripatti, Samuli; Aulchenko, Yurii S.; Zhang, Weihua; Yuan, Xin; Lim, Noha; Luan, Jian'an; Ashford, Sofie; Wheeler, Eleanor; Young, Elizabeth H.; Hadley, David; Thompson, John R.; Braund, Peter S.; Johnson, Toby; Struchalin, Maksim; Surakka, Ida; Luben, Robert; Khaw, Kay-Tee; Rodwell, Sheila A.; Loos, Ruth J.F.; [...]
  • imprint: Ovid Technologies (Wolters Kluwer Health), 2010
  • Published in: Arteriosclerosis, Thrombosis, and Vascular Biology
  • Language: English
  • DOI: 10.1161/atvbaha.109.201020
  • ISSN: 1079-5642; 1524-4636
  • Keywords: Cardiology and Cardiovascular Medicine
  • Origination:
  • Footnote:
  • Description: <jats:p> <jats:bold> <jats:italic>Objective—</jats:italic> </jats:bold> Genetic studies might provide new insights into the biological mechanisms underlying lipid metabolism and risk of CAD. We therefore conducted a genome-wide association study to identify novel genetic determinants of low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), and triglycerides. </jats:p> <jats:p> <jats:bold> <jats:italic>Methods and Results—</jats:italic> </jats:bold> We combined genome-wide association data from 8 studies, comprising up to 17 723 participants with information on circulating lipid concentrations. We did independent replication studies in up to 37 774 participants from 8 populations and also in a population of Indian Asian descent. We also assessed the association between single-nucleotide polymorphisms (SNPs) at lipid loci and risk of CAD in up to 9 633 cases and 38 684 controls. We identified 4 novel genetic loci that showed reproducible associations with lipids (probability values, 1.6×10 <jats:sup>−8</jats:sup> to 3.1×10 <jats:sup>−10</jats:sup> ). These include a potentially functional SNP in the <jats:italic>SLC39A8</jats:italic> gene for HDL-C, an SNP near the <jats:italic>MYLIP/GMPR</jats:italic> and <jats:italic>PPP1R3B</jats:italic> genes for LDL-C, and at the <jats:italic>AFF1</jats:italic> gene for triglycerides. SNPs showing strong statistical association with 1 or more lipid traits at the <jats:italic>CELSR2</jats:italic> , <jats:italic>APOB</jats:italic> , <jats:italic>APOE-C1-C4-C2</jats:italic> cluster, <jats:italic>LPL</jats:italic> , <jats:italic>ZNF259-APOA5-A4-C3-A1</jats:italic> cluster and <jats:italic>TRIB1</jats:italic> loci were also associated with CAD risk (probability values, 1.1×10 <jats:sup>−3</jats:sup> to 1.2×10 <jats:sup>−9</jats:sup> ). </jats:p> <jats:p> <jats:bold> <jats:italic>Conclusion—</jats:italic> </jats:bold> We have identified 4 novel loci associated with circulating lipids. We also show that in addition to those that are largely associated with LDL-C, genetic loci mainly associated with circulating triglycerides and HDL-C are also associated with risk of CAD. These findings potentially provide new insights into the biological mechanisms underlying lipid metabolism and CAD risk. </jats:p>