• Media type: E-Article
  • Title: Antimicrobial and Cytotoxic Evaluation of New Quinazoline Derivatives
  • Contributor: Turan-Zitouni, Gülhan; Yurttaş, Leyla; Saka, Güner; Cantürk, Zerrin; Gencer, Hülya Karaca; Baysal, Merve; Kaplancιklι, Zafer Asιm
  • Published: SAGE Publications, 2016
  • Published in: Natural Product Communications
  • Extent: 1934578X1601101
  • Language: English
  • DOI: 10.1177/1934578x1601101105
  • ISSN: 1934-578X; 1555-9475
  • Keywords: Complementary and alternative medicine ; Plant Science ; Drug Discovery ; Pharmacology ; General Medicine
  • Abstract: <jats:p> The synthesis of nine new quinazoline derivatives (2a-2i) and evaluation of their antimicrobial and cytotoxic activities were aims of the present work. For the synthesis of the compounds, 2-chloro-6,7-dimethoxyquinazolin-4-amine was used as the initial starting material. The intermediate product, 2-hydrazinyl-6,7-dimethoxyquinazolin-4-amine, was reacted with appropriate aromatic aldehydes to obtain 2-(2-benzylidenehydrazinyl)-6,7-dimethoxyquinazolin-4-amine derivatives as final compounds. The structures of the compounds were elucidated by <jats:sup>1</jats:sup>H- and <jats:sup>13</jats:sup>C-NMR, IR, and MS analyses. The new pure compounds were evaluated for their potential antimicrobial and cytotoxic activities using in vitro microdilution and cell culture techniques, respectively. The compounds 2e and 2f may be promising candidates for the treatment of fungal infections with their activity and cytotoxicity. </jats:p>
  • Description: <jats:p> The synthesis of nine new quinazoline derivatives (2a-2i) and evaluation of their antimicrobial and cytotoxic activities were aims of the present work. For the synthesis of the compounds, 2-chloro-6,7-dimethoxyquinazolin-4-amine was used as the initial starting material. The intermediate product, 2-hydrazinyl-6,7-dimethoxyquinazolin-4-amine, was reacted with appropriate aromatic aldehydes to obtain 2-(2-benzylidenehydrazinyl)-6,7-dimethoxyquinazolin-4-amine derivatives as final compounds. The structures of the compounds were elucidated by <jats:sup>1</jats:sup>H- and <jats:sup>13</jats:sup>C-NMR, IR, and MS analyses. The new pure compounds were evaluated for their potential antimicrobial and cytotoxic activities using in vitro microdilution and cell culture techniques, respectively. The compounds 2e and 2f may be promising candidates for the treatment of fungal infections with their activity and cytotoxicity. </jats:p>
  • Footnote:
  • Access State: Open Access