Alemtuzumab Combined with Dexamethasone, Followed By Alemtuzumab Maintenance or Allo-SCT in “ultra High-risk” CLL: Final Results from the CLL2O Phase II Study

Media type: E-Article
Title: Alemtuzumab Combined with Dexamethasone, Followed By Alemtuzumab Maintenance or Allo-SCT in “ultra High-risk” CLL: Final Results from the CLL2O Phase II Study
Contributor: Stilgenbauer, Stephan; Cymbalista, Florence; Leblond, Véronique; Delmer, Alain; Ibach, Stefan; Choquet, Sylvain; Dartigeas, Caroline; Cazin, Bruno; Tournilhac, Olivier; Pegourie, Brigitte; Seiler, Till M; Sökler, Martin; Zirlik, Katja; Alt, Jürgen; Huber, Henriette; Bloehdorn, Johannes; Tausch, Eugen; Zenz, Thorsten; Hallek, Michael; Schetelig, Johannes; Dreger, Peter; Döhner, Hartmut
imprint: American Society of Hematology, 2014
Published in: Blood
Language: English
DOI: 10.1182/blood.v124.21.1991.1991
ISSN: 0006-4971; 1528-0020
Keywords: Cell Biology ; Hematology ; Immunology ; Biochemistry
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Description: <jats:title>Abstract</jats:title> <jats:p>CLL with deletion 17p (17p-) or refractory to fludarabine (F)-based regimens is characterized by poor prognosis. The cooperative French/German CLL2O study aimed at achieving deep and durable response in this population by combining alemtuzumab (A) and dexamethasone (D) induction, followed by consolidation with A maintenance or allogeneic stem-cell transplantation (allo-SCT).</jats:p> <jats:p>Induction treatment consisted of subcutaneous A (30mg, 3x weekly) combined with oral D (40 mg days 1-4 and 15-18), both at 28 day cycles, and prophylactic pegfilgrastim 6 mg on days 1 and 15. If at least SD was achieved after 3 cycles, consolidation was scheduled with either allo-SCT or A maintenance (30mg every 2 weeks for up to 2 years), at discretion of pt and physician.</jats:p> <jats:p>Between January 2008 and December 2011, 131 eligible pts were enrolled at 26 centers. Pts were generally subdivided for this analysis into three cohorts: 17p- 1st line, 17p- relapsed (not refractory) and refractory (i.e. no response or relapse within 6 months) to F-based or similar (i.e. pentostatin, cladribine, bendamustine) therapy. All three cohorts where characterized by high-risk baseline disease features (detailed in Table).</jats:p> <jats:p>During induction, a total of 467 non-hematologic AEs were recorded, predominantly (79%) of minor grade, while 36%, 43%, and 50% of pts in the 3 cohorts had at least one event of grade 3 or higher (Table).</jats:p> <jats:p>ORR (best response) was high in all three cohorts, but CRs were rarely observed outside the 17p- 1st line cohort (Table). Correspondingly, there were marked differences in PFS and OS between the three cohorts with far better outcome in the 17p- 1st line group (see Table and Figure 1).</jats:p> <jats:p>Consolidation treatment was performed as A maintenance (median duration 42 weeks, range 2 – 112.4) in 37%, and allo-SCT in 25%, with a median age of 69 and 57 y in these subgroups. The main reasons for going off-study without consolidation were death due to infection in 19 patients (15%), largely from the F-refractory cohort (n=16), with the majority being non-responders to study treatment (n=11); CLL progression (10%), and other toxicity (9%). Five pts who did not receive immediate consolidation treatment per protocol later underwent allo-SCT, 2 of these have died (sepsis, GvHD).</jats:p> <jats:p>During A maintenance, grade 3/4 toxicity consisted of neutropenia in 47% and thrombocytopenia in 12%. Serious (grade 3/4) non-CMV infection occurred in 17%, 10%, 13% in the 3 cohorts.</jats:p> <jats:p>When comparing PFS between A maintenance and allo-SCT, there were 41 (84%) and 16 (48%) events, respectively, significantly favoring SCT (Figure 2). Six pts who started A maintenance later underwent allo-SCT, 4 of them after relapse. After median follow up of 20 months from allo-SCT, 12 pts have died, 7 because of non-relapse mortality and 5 subsequent to CLL progression.</jats:p> <jats:p>In conclusion, the combination of A and D, followed by A maintenance or allo-SCT showed high response rates in ultra high-risk CLL with expected toxicity. For 17p- 1st line treatment, the results compare favorably to FCR (CLL8: ORR 68%, median PFS 11.3 mo). On the other hand, in F-refractory and 17p- relapsed CLL, the high ORR did not translate into prolongation of PFS. Allo-SCT appears to offer superior disease control in eligible patients despite prior A exposure. Overall, this mature trial may serve as a historical benchmark for comparison of novel agents in ultra high-risk CLL.</jats:p> <jats:p>Table 1 Parameter 17p- 1st line 17p- relapsed F-refractory Number of patients 42 28 61 Median age (yrs) 66.5 64 66 Binet C (%) 45 57 77 B symptoms (%) 40 32 31 ECOG 1/2 (%) 38 39 56 Median thymidine kinase (U/l) 35 48.1 27.6 Median β2MG (mg/dl) 3.8 5.1 4.7 Unmutated IGHV (%) 90 93 87 17p- (%) 100 100 49 Prior lines (median) n.a. 2 3 Prior rituximab (%) n.a. 71 93</jats:p> <jats:p>AEs during induction (grade 3/4) Table 2 All AEs (%) 36 43 50 Neutropenia (%) 24 36 67 Anemia (%) 14 36 21 Thrombocytopenia (%) 12 39 31 Non-CMV infection (%) 19 36 36 CMV infection (%) 7 0 2</jats:p> <jats:p>Efficacy (median follow-up 41.3 mo) Table 3 ORR (%) 97 79 69 CR (%) 21 4 3 Median PFS (mo) 32.8 10.3 9.7 Median OS (mo) >60.0 21.4 17.3</jats:p> <jats:p>Figure 1 Figure 1. Figure 2 Figure 2.</jats:p> <jats:sec> <jats:title>Disclosures</jats:title> <jats:p>Stilgenbauer: Amgen: Honoraria, Research Funding; Genzyme: Honoraria, Research Funding.</jats:p> </jats:sec>
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