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Velthorst, Eva; Nieman, Dorien H.; Linszen, Don; Becker, Hiske; de Haan, Lieuwe; Dingemans, Peter M.; Birchwood, Max; Patterson, Paul; Salokangas, Raimo K. R.; Heinimaa, Markus; Heinz, Andreas; Juckel, Georg; von Reventlow, Heinrich Graf; French, Paul; Stevens, Helen; Schultze-Lutter, Frauke; Klosterkötter, Joachim; Ruhrmann, Stephan

Disability in people clinically at high risk of psychosis

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  • Media type: E-Article
  • Title: Disability in people clinically at high risk of psychosis
  • Contributor: Velthorst, Eva; Nieman, Dorien H.; Linszen, Don; Becker, Hiske; de Haan, Lieuwe; Dingemans, Peter M.; Birchwood, Max; Patterson, Paul; Salokangas, Raimo K. R.; Heinimaa, Markus; Heinz, Andreas; Juckel, Georg; von Reventlow, Heinrich Graf; French, Paul; Stevens, Helen; Schultze-Lutter, Frauke; Klosterkötter, Joachim; Ruhrmann, Stephan
  • imprint: Royal College of Psychiatrists, 2010
  • Published in: British Journal of Psychiatry
  • Language: English
  • DOI: 10.1192/bjp.bp.109.075036
  • ISSN: 1472-1465; 0007-1250
  • Keywords: Psychiatry and Mental health
  • Origination:
  • Footnote:
  • Description: <jats:sec><jats:title>Background</jats:title><jats:p>Decline in social functioning occurs in individuals who later develop psychosis.</jats:p></jats:sec><jats:sec><jats:title>Aims</jats:title><jats:p>To investigate whether baseline differences in disability are present in those who do and those who do not make a transition to psychosis in a group clinically at high risk and whether disability is a risk factor for transition.</jats:p></jats:sec><jats:sec><jats:title>Method</jats:title><jats:p>Prospective multicentre, naturalistic field study with an 18-month follow-up period on 245 help-seeking individuals clinically at high risk. Disability was assessed with the Disability Assessment Schedule of the World Health Organization (WHODAS–II).</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>At baseline, the transition group displayed significantly greater difficulties in making new friends (<jats:italic>z</jats:italic> =−3.40, <jats:italic>P</jats:italic> = 0.001), maintaining a friendship (<jats:italic>z</jats:italic> =−3.00, <jats:italic>P</jats:italic> = 0.003), dealing with people they do not know (<jats:italic>z</jats:italic> =−2.28, <jats:italic>P</jats:italic> = 0.023) and joining community activities (<jats:italic>z</jats:italic> =−2.0, <jats:italic>P</jats:italic> = 0.05) compared with the non-transition group. In Cox regression, difficulties in getting along with people significantly contributed to the prediction of transition to psychosis in our sample (β = 0.569, s.e. = 0.184, Wald = 9.548, <jats:italic>P</jats:italic> = 0.002, hazard ratio (HR) = 1.767, 95% CI 1.238–2.550).</jats:p></jats:sec><jats:sec><jats:title>Conclusions</jats:title><jats:p>Certain domains of social disability might contribute to the prediction of psychosis in a sample clinically at high risk.</jats:p></jats:sec>
  • Access State: Open Access