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Boulanger, Marion; Al‐Shahi Salman, Rustam; Kerssens, Jan; Wild, Sarah H.

Association between diabetes mellitus and incidence of intracerebral haemorrhage and case fatality rates: A retrospective population‐based cohort study

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  • Media type: E-Article
  • Title: Association between diabetes mellitus and incidence of intracerebral haemorrhage and case fatality rates: A retrospective population‐based cohort study
  • Contributor: Boulanger, Marion; Al‐Shahi Salman, Rustam; Kerssens, Jan; Wild, Sarah H.
  • imprint: Wiley, 2017
  • Published in: Diabetes, Obesity and Metabolism
  • Language: English
  • DOI: 10.1111/dom.12934
  • ISSN: 1463-1326; 1462-8902
  • Keywords: Endocrinology ; Endocrinology, Diabetes and Metabolism ; Internal Medicine
  • Origination:
  • Footnote:
  • Description: <jats:p>We investigated the associations between diabetes (type 1, type 2 or no diabetes) and intracerebral haemorrhage (<jats:styled-content style="fixed-case">ICH</jats:styled-content>) incidence as well as case fatality after <jats:styled-content style="fixed-case">ICH</jats:styled-content>, in a retrospective cohort study of people aged 40 to 89 years in <jats:styled-content style="fixed-case">S</jats:styled-content>cotland during the period 2004 to 2013, using linkage of population‐based records of diagnosed diabetes, hospital discharges and deaths. We calculated <jats:styled-content style="fixed-case">ICH</jats:styled-content> incidence and 30‐day case fatality after hospital admission for <jats:styled-content style="fixed-case">ICH</jats:styled-content>, along with their relative risks (<jats:styled-content style="fixed-case">RR</jats:styled-content>) and 95% confidence intervals (<jats:styled-content style="fixed-case">CIs</jats:styled-content>), among people with type 1 or type 2 diabetes compared to people without diabetes, adjusting for age, sex and socio‐economic status (<jats:styled-content style="fixed-case">SES</jats:styled-content>). There were 77, 1275 and 9778 incident <jats:styled-content style="fixed-case">ICH</jats:styled-content> events and the case‐fatality rate was 44% (95% <jats:styled-content style="fixed-case">CI</jats:styled-content> 33, 57), 38% (95% <jats:styled-content style="fixed-case">CI</jats:styled-content> 35, 41) and 36% (95% <jats:styled-content style="fixed-case">CI</jats:styled-content> 35, 37) in people with type 1, type 2 and without diabetes, respectively. In comparison with absence of diabetes, type 1 diabetes was associated with a higher incidence of <jats:styled-content style="fixed-case">ICH</jats:styled-content> (1.74, 95% <jats:styled-content style="fixed-case">CI</jats:styled-content> 1.38‐2.21) and higher case fatality after <jats:styled-content style="fixed-case">ICH</jats:styled-content> (1.35, 95% <jats:styled-content style="fixed-case">CI</jats:styled-content> 1.01‐1.70), after adjustment for age, sex and <jats:styled-content style="fixed-case">SES</jats:styled-content>. The small increases in <jats:styled-content style="fixed-case">ICH</jats:styled-content> incidence (1.06, 95% <jats:styled-content style="fixed-case">CI</jats:styled-content> 0.99‐1.12) and case‐fatality (1.04, 95% <jats:styled-content style="fixed-case">CI</jats:styled-content> 0.96‐1.13) in people with type 2 diabetes compared with people without diabetes were not statistically significant.</jats:p>