• Media type: E-Article
  • Title: SHP2 drives inflammation-triggered insulin resistance by reshaping tissue macrophage populations
  • Contributor: Paccoud, Romain; Saint-Laurent, Céline; Piccolo, Enzo; Tajan, Mylène; Dortignac, Alizée; Pereira, Ophélie; Le Gonidec, Sophie; Baba, Inès; Gélineau, Adélaïde; Askia, Haoussa; Branchereau, Maxime; Charpentier, Julie; Personnaz, Jean; Branka, Sophie; Auriau, Johanna; Deleruyelle, Simon; Canouil, Mickaël; Beton, Nicolas; Salles, Jean-Pierre; Tauber, Maithé; Weill, Jacques; Froguel, Philippe; Neel, Benjamin G.; Araki, Toshiyuki; [...]
  • imprint: American Association for the Advancement of Science (AAAS), 2021
  • Published in: Science Translational Medicine
  • Language: English
  • DOI: 10.1126/scitranslmed.abe2587
  • ISSN: 1946-6234; 1946-6242
  • Keywords: General Medicine
  • Origination:
  • Footnote:
  • Description: <jats:p>Hyperactive SHP2 promotes inflammation-driven insulin resistance by skewing macrophage balance in metabolic tissues and may be a target in T2D.</jats:p>