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Media type:
E-Article
Title:
eIF4G--A Multipurpose Ribosome Adapter?
Contributor:
Hentze, Matthias W.
Published:
American Association for the Advancement of Science (AAAS), 1997
Published in:
Science, 275 (1997) 5299, Seite 500-501
Language:
English
DOI:
10.1126/science.275.5299.500
ISSN:
0036-8075;
1095-9203
Origination:
Footnote:
Description:
Messenger RNAs are translated into protein—a complex enterprise. Now, in work from a number of laboratories, one small adapter protein is shown to be a central player in several variations on the process. In his Perspective, Hentze describes how eIF4G serves as an adapter that binds the small ribosome subunit to the messenger RNA, working in different ways when the message has a 7 mG cap at its 5 ' end or a polyadenylated tail at its 3 ' end.