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Fluckiger, Aurélie; Daillère, Romain; Sassi, Mohamed; Sixt, Barbara Susanne; Liu, Peng; Loos, Friedemann; Richard, Corentin; Rabu, Catherine; Alou, Maryam Tidjani; Goubet, Anne-Gaëlle; Lemaitre, Fabien; Ferrere, Gladys; Derosa, Lisa; Duong, Connie P. M.; Messaoudene, Meriem; Gagné, Andréanne; Joubert, Philippe; De Sordi, Luisa; Debarbieux, Laurent; Simon, Sylvain; Scarlata, Clara-Maria; Ayyoub, Maha; Palermo, Belinda; Facciolo, Francesco; [...]

Cross-reactivity between tumor MHC class I–restricted antigens and an enterococcal bacteriophage

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  • Media type: E-Article
  • Title: Cross-reactivity between tumor MHC class I–restricted antigens and an enterococcal bacteriophage
  • Contributor: Fluckiger, Aurélie; Daillère, Romain; Sassi, Mohamed; Sixt, Barbara Susanne; Liu, Peng; Loos, Friedemann; Richard, Corentin; Rabu, Catherine; Alou, Maryam Tidjani; Goubet, Anne-Gaëlle; Lemaitre, Fabien; Ferrere, Gladys; Derosa, Lisa; Duong, Connie P. M.; Messaoudene, Meriem; Gagné, Andréanne; Joubert, Philippe; De Sordi, Luisa; Debarbieux, Laurent; Simon, Sylvain; Scarlata, Clara-Maria; Ayyoub, Maha; Palermo, Belinda; Facciolo, Francesco; [...]
  • Published: American Association for the Advancement of Science (AAAS), 2020
  • Published in: Science, 369 (2020) 6506, Seite 936-942
  • Language: English
  • DOI: 10.1126/science.aax0701
  • ISSN: 1095-9203; 0036-8075
  • Origination:
  • Footnote:
  • Description: Phages and cancer immunity Gut bacteria are involved in the education of T cell immune responses, and the intestinal ecosystem influences anticancer immunity. Fluckiger et al. report microbial antigens that might cross-react with antigens associated with tumor cells. They found that a type of intestinal bacteria called enterococci harbor a bacteriophage that modulates immune responses. In mouse models, administration of enterococci containing the bacteriophage boosted T cell responses after treatment with chemotherapy or programmed cell death protein 1 (PD-1) blockade. In humans, the presence of the bacteriophage was associated with improved survival after PD-1 immunotherapy. A fraction of human T cells specific for naturally processed melanoma epitopes appeared to be able to recognize microbial peptides. This “molecular mimicry” may represent cross-reactivity between tumors and microbial antigens. Science , this issue p. 936