Ziegler, Hanne L.;
Hansen, Harald S.;
Stærk, Dan;
Christensen, Søren Brøgger;
Hägerstrand, Henry;
Jaroszewski, Jerzy W.
The Antiparasitic Compound Licochalcone A Is a Potent Echinocytogenic Agent That Modifies the Erythrocyte Membrane in the Concentration Range Where Antiplasmodial Activity Is Observed
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Media type:
E-Article
Title:
The Antiparasitic Compound Licochalcone A Is a Potent Echinocytogenic Agent That Modifies the Erythrocyte Membrane in the Concentration Range Where Antiplasmodial Activity Is Observed
Contributor:
Ziegler, Hanne L.;
Hansen, Harald S.;
Stærk, Dan;
Christensen, Søren Brøgger;
Hägerstrand, Henry;
Jaroszewski, Jerzy W.
Published:
American Society for Microbiology, 2004
Published in:
Antimicrobial Agents and Chemotherapy, 48 (2004) 10, Seite 4067-4071
Language:
English
DOI:
10.1128/aac.48.10.4067-4071.2004
ISSN:
0066-4804;
1098-6596
Origination:
Footnote:
Description:
ABSTRACT The well-known antiparasitic compound licochalcone A is a potent membrane-active agent that transforms normal erythrocytes into echinocytes in parallel with the inhibition of growth of Plasmodium falciparum cultures, the in vitro antiplasmodial effect apparently being an indirect effect on the host cell. In vitro experiments with synchronous cultures demonstrate that inhibition of invasion is the principal mechanism of growth inhibition. The erythrocyte membrane-modifying effect was also transiently observed in vivo in mice after intravenous administration.