• Media type: E-Article
  • Title: Myeloperoxidase Attenuates Pathogen Clearance during Plasmodium yoelii Nonlethal Infection
  • Contributor: Theeß, Wiebke; Sellau, Julie; Steeg, Christiane; Klinke, Anna; Baldus, Stephan; Cramer, Jakob P.; Jacobs, Thomas
  • imprint: American Society for Microbiology, 2017
  • Published in: Infection and Immunity
  • Language: English
  • DOI: 10.1128/iai.00475-16
  • ISSN: 0019-9567; 1098-5522
  • Keywords: Infectious Diseases ; Immunology ; Microbiology ; Parasitology
  • Origination:
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  • Description: <jats:title>ABSTRACT</jats:title> <jats:p> Myeloperoxidase (MPO), a leukocyte-derived enzyme mainly secreted by activated neutrophils, is known to be involved in the immune response during bacterial and fungal infection and inflammatory diseases. Nevertheless, the role of MPO in a parasitic disease like malaria is unknown. We hypothesized that MPO contributes to parasite clearance. To address this hypothesis, we used <jats:named-content content-type="genus-species">Plasmodium yoelii</jats:named-content> nonlethal infection in wild-type and MPO-deficient mice as a murine malaria model. We detected high MPO plasma levels in wild-type mice with <jats:named-content content-type="genus-species">Plasmodium yoelii</jats:named-content> infection. Unexpectedly, infected MPO-deficient mice did not show increased parasite loads but were able to clear the infection more rapidly than wild-type mice. Additionally, the presence of neutrophils at the onset of infection seemed not to be essential for the control of the parasitemia. The effect of decreased parasite levels in MPO-deficient mice was absent from animals lacking mature T and B cells, indicating that this effect is most likely dependent on adaptive immune response mechanisms. Indeed, we observed increased gamma interferon and tumor necrosis factor alpha production by T cells in infected MPO-deficient mice. Together, these results suggest that MPO modulates the adaptive immune response during malaria infection, leading to an attenuated parasite clearance. </jats:p>
  • Access State: Open Access