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Media type:
E-Article
Title:
Russian “Successful” Clone B0/W148 of Mycobacterium tuberculosis Beijing Genotype: a Multiplex PCR Assay for Rapid Detection and Global Screening
Contributor:
Mokrousov, Igor;
Narvskaya, Olga;
Vyazovaya, Anna;
Otten, Tatiana;
Jiao, Wei-Wei;
Gomes, Lia Lima;
Suffys, Philip N.;
Shen, A-Dong;
Vishnevsky, Boris
Description:
<jats:title>ABSTRACT</jats:title>
<jats:p>
We describe a multiplex PCR assay to detect the
<jats:named-content content-type="genus-species">Mycobacterium tuberculosis</jats:named-content>
Beijing genotype variant B0/W148, which is considered a “successful” clone of
<jats:named-content content-type="genus-species">M. tuberculosis</jats:named-content>
, widespread in Russia. Specificity and sensitivity of the assay were 100% based on the analysis of a collection of 516
<jats:named-content content-type="genus-species">M. tuberculosis</jats:named-content>
isolates of different genotypes and origins. This assay may be used for accurate and simple detection and surveillance of this clinically and epidemiologically important variant of
<jats:named-content content-type="genus-species">M. tuberculosis</jats:named-content>
.
</jats:p>