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Sargeant, Jack A.; Jelleyman, Charlotte; Coull, Nicole A.; Edwardson, Charlotte L.; Henson, Joseph; King, James A.; Khunti, Kamlesh; McCarthy, Matthew; Rowlands, Alex V.; Stensel, David J.; Waller, Helen L.; Webb, David R.; Davies, Melanie J.; Yates, Thomas

Improvements in Glycemic Control After Acute Moderate-Intensity Continuous or High-Intensity Interval Exercise Are Greater in South Asians Than White Europeans With Nondiabetic Hyperglycemia: A Randomized Crossover Study

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  • Media type: E-Article
  • Title: Improvements in Glycemic Control After Acute Moderate-Intensity Continuous or High-Intensity Interval Exercise Are Greater in South Asians Than White Europeans With Nondiabetic Hyperglycemia: A Randomized Crossover Study
  • Contributor: Sargeant, Jack A.; Jelleyman, Charlotte; Coull, Nicole A.; Edwardson, Charlotte L.; Henson, Joseph; King, James A.; Khunti, Kamlesh; McCarthy, Matthew; Rowlands, Alex V.; Stensel, David J.; Waller, Helen L.; Webb, David R.; Davies, Melanie J.; Yates, Thomas
  • Published: American Diabetes Association, 2021
  • Published in: Diabetes Care, 44 (2021) 1, Seite 201-209
  • Language: English
  • DOI: 10.2337/dc20-1393
  • ISSN: 0149-5992; 1935-5548
  • Keywords: Advanced and Specialized Nursing ; Endocrinology, Diabetes and Metabolism ; Internal Medicine
  • Origination:
  • Footnote:
  • Description: OBJECTIVETo examine whether circulating metabolic responses to low-volume high-intensity interval exercise (LV-HIIE) or continuous moderate-intensity aerobic exercise (CME) differ between white Europeans and South Asians with nondiabetic hyperglycemia (NDH).RESEARCH DESIGN AND METHODSThirteen white Europeans and 10 South Asians (combined median [interquartile range] age 67 [60–68] years, HbA1c 5.9% [5.8–6.1%] [41.0 (39.9–43.2) mmol ⋅ mol−1]) completed three 6-h conditions (sedentary control [CON], LV-HIIE, and CME) in a randomized order. Exercise conditions contained a single bout of LV-HIIE and CME, respectively (each ending at 2 h), with meals provided at 0 and 3 h. Circulating glucose (primary outcome), insulin, insulin resistance index (IRI), triglycerides, and nonesterified fatty acids were measured at 0, 0.5, 1, 2, 3, 3.5, 4, 5, and 6 h. Data were analyzed as postexercise time-averaged area under the curve (AUC) adjusted for age, sex, and preexercise AUC.RESULTSGlucose was similar in each condition and with ethnicity, with no condition-by-ethnicity interaction (P ≥ 0.28). However, insulin was lower in LV-HIIE (mean [95% CI] −44.4 [−23.7, −65.1] mU ⋅ L−1) and CME (−33.8 [−13.7, −53.9] mU ⋅ L−1) compared with CON. Insulin responses were greater in South Asians (interaction P = 0.03) such that values were similar in each ethnicity during exercise conditions, despite being 33% higher in South Asians during CON. IRI followed a similar pattern to insulin. Lipids were unaffected by exercise.CONCLUSIONSReductions in insulin and insulin resistance after acute LV-HIIE and CME are greater in South Asians than in white Europeans with NDH. Further trials are required to examine the longer-term impact of LV-HIIE and CME on cardiometabolic health.
  • Access State: Open Access