> Details

Granata, Guido; Bartoloni, Alessandro; Codeluppi, Mauro; Contadini, Ilaria; Cristini, Francesco; Fantoni, Massimo; Ferraresi, Alice; Fornabaio, Chiara; Grasselli, Sara; Lagi, Filippo; Masucci, Luca; Puoti, Massimo; Raimondi, Alessandro; Taddei, Eleonora; Trapani, Filippo; Viale, Pierluigi; Johnson, Stuart; Petrosillo, Nicola

The Burden of Clostridioides Difficile Infection during the COVID-19 Pandemic: A Retrospective Case-Control Study in Italian Hospitals (CloVid)

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  • Media type: E-Article
  • Title: The Burden of Clostridioides Difficile Infection during the COVID-19 Pandemic: A Retrospective Case-Control Study in Italian Hospitals (CloVid)
  • Contributor: Granata, Guido; Bartoloni, Alessandro; Codeluppi, Mauro; Contadini, Ilaria; Cristini, Francesco; Fantoni, Massimo; Ferraresi, Alice; Fornabaio, Chiara; Grasselli, Sara; Lagi, Filippo; Masucci, Luca; Puoti, Massimo; Raimondi, Alessandro; Taddei, Eleonora; Trapani, Filippo; Viale, Pierluigi; Johnson, Stuart; Petrosillo, Nicola
  • imprint: MDPI AG, 2020
  • Published in: Journal of Clinical Medicine
  • Language: English
  • DOI: 10.3390/jcm9123855
  • ISSN: 2077-0383
  • Keywords: General Medicine
  • Origination:
  • Footnote:
  • Description: <jats:p>Data on the burden of Clostridioides difficile infection (CDI) in Coronavirus Disease 2019 (COVID-19) patients are scant. We conducted an observational, retrospective, multicenter, 1:3 case (COVID-19 patients with CDI)-control (COVID-19 patients without CDI) study in Italy to assess incidence and outcomes, and to identify risk factors for CDI in COVID-19 patients. From February through July 2020, 8402 COVID-19 patients were admitted to eight Italian hospitals; 38 CDI cases were identified, including 32 hospital-onset-CDI (HO-CDI) and 6 community-onset, healthcare-associated-CDI (CO-HCA-CDI). HO-CDI incidence was 4.4 × 10,000 patient-days. The percentage of cases recovering without complications at discharge (i.e., pressure ulcers, chronic heart decompensation) was lower than among controls (p = 0.01); in-hospital stays was longer among cases, 35.0 versus 19.4 days (p = 0.0007). The presence of a previous hospitalisation (p = 0.001), previous steroid administration (p = 0.008) and the administration of antibiotics during the stay (p = 0.004) were risk factors associated with CDI. In conclusions, CDI complicates COVID-19, mainly in patients with co-morbidities and previous healthcare exposures. Its association with antibiotic usage and hospital acquired bacterial infections should lead to strengthen antimicrobial stewardship programmes and infection prevention and control activities.</jats:p>
  • Access State: Open Access